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学科主题临床医学
Salvage radiotherapy in patients with local recurrent esophageal cancer after radical radiochemotherapy
Zhou, Zhi-guo1,2; Zhen, Chan-jun2; Bai, Wen-wen2; Zhang, Ping2; Qiao, Xue-ying2; Liang, Jun-li2; Gao, Xian-shu1; Wang, Shuo-shuo2
关键词Salvage radiotherapy Esophagus Squamous cell carcinoma Local recurrence
刊名RADIATION ONCOLOGY
2015-02-27
DOI10.1186/s13014-015-0358-z
10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; LYMPH-NODE RECURRENCE ; RADIATION-THERAPY ; MALIGNANT DYSPHAGIA ; CURATIVE RESECTION ; CHEMOTHERAPY ; CHEMORADIATION ; PALLIATION ; PROGNOSIS ; SURGERY
英文摘要

Purpose: The aim of this study was to evaluate the salvage radiotherapy outcome in patients with local recurrent esophageal cancer after radical radiochemotherapy (RCT).

Methods: A total of 114 patients with local recurrent esophageal squamous cell carcinoma after initial radical RCT were retrospectively analyzed. Fifty-five (55) patients belonged to the salvage radiotherapy group (SR group) and 59 patients to the non-salvage radiotherapy group (NSR group).

Results: The median survival time after-recurrence was 4 months in all patients. The 1, 2, 3 year overall survival (OS) rates were 83.6%, 41.8% and 21.8% respectively in the SR group, and 57.6%, 16.9%, and 8.5% in the NSR group. The 6-month and 1-year survival rates after-recurrence were 41.8% and 16.4% respectively in the SR group, and 11.9% and 3.4% respectively in the NSR group. A salvage radiation dose > 50 Gy after initial radical RCT, improved the survival of patients with local recurrent esophageal cancer. Three patients (5.45%) from the SR group showed more than 3-grade radiation pneumonitis. In addition, esophageal fistula/perforation was observed in 11 cases (20.0%) in the SR group and in 8 cases (13.6%) in the NSR group.

Conclusions: Salvage treatment after definitive RCT may improve the overall survival and survival after-recurrence of patients with local recurrent esophageal cancer.

语种英语
WOS记录号WOS:000350728700001
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58378
专题北京大学第一临床医学院_肿瘤化疗科
北京大学第一临床医学院_放射治疗科
作者单位1.Peking Univ, Hosp 1, Dept Radiat Oncol, Beijing 100034, Peoples R China
2.Hebei Med Univ, Hosp 4, Dept Radiat Oncol, Shijiazhuang 050011, Hebei, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Zhi-guo,Zhen, Chan-jun,Bai, Wen-wen,et al. Salvage radiotherapy in patients with local recurrent esophageal cancer after radical radiochemotherapy[J]. RADIATION ONCOLOGY,2015,10.
APA Zhou, Zhi-guo.,Zhen, Chan-jun.,Bai, Wen-wen.,Zhang, Ping.,Qiao, Xue-ying.,...&Wang, Shuo-shuo.(2015).Salvage radiotherapy in patients with local recurrent esophageal cancer after radical radiochemotherapy.RADIATION ONCOLOGY,10.
MLA Zhou, Zhi-guo,et al."Salvage radiotherapy in patients with local recurrent esophageal cancer after radical radiochemotherapy".RADIATION ONCOLOGY 10(2015).
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