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学科主题: 临床医学
题名:
Salvage radiotherapy in patients with local recurrent esophageal cancer after radical radiochemotherapy
作者: Zhou, Zhi-guo1,2; Zhen, Chan-jun2; Bai, Wen-wen2; Zhang, Ping2; Qiao, Xue-ying2; Liang, Jun-li2; Gao, Xian-shu1; Wang, Shuo-shuo2
关键词: Salvage radiotherapy ; Esophagus ; Squamous cell carcinoma ; Local recurrence
刊名: RADIATION ONCOLOGY
发表日期: 2015-02-27
DOI: 10.1186/s13014-015-0358-z
卷: 10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: SQUAMOUS-CELL CARCINOMA ; LYMPH-NODE RECURRENCE ; RADIATION-THERAPY ; MALIGNANT DYSPHAGIA ; CURATIVE RESECTION ; CHEMOTHERAPY ; CHEMORADIATION ; PALLIATION ; PROGNOSIS ; SURGERY
英文摘要:

Purpose: The aim of this study was to evaluate the salvage radiotherapy outcome in patients with local recurrent esophageal cancer after radical radiochemotherapy (RCT).

Methods: A total of 114 patients with local recurrent esophageal squamous cell carcinoma after initial radical RCT were retrospectively analyzed. Fifty-five (55) patients belonged to the salvage radiotherapy group (SR group) and 59 patients to the non-salvage radiotherapy group (NSR group).

Results: The median survival time after-recurrence was 4 months in all patients. The 1, 2, 3 year overall survival (OS) rates were 83.6%, 41.8% and 21.8% respectively in the SR group, and 57.6%, 16.9%, and 8.5% in the NSR group. The 6-month and 1-year survival rates after-recurrence were 41.8% and 16.4% respectively in the SR group, and 11.9% and 3.4% respectively in the NSR group. A salvage radiation dose > 50 Gy after initial radical RCT, improved the survival of patients with local recurrent esophageal cancer. Three patients (5.45%) from the SR group showed more than 3-grade radiation pneumonitis. In addition, esophageal fistula/perforation was observed in 11 cases (20.0%) in the SR group and in 8 cases (13.6%) in the NSR group.

Conclusions: Salvage treatment after definitive RCT may improve the overall survival and survival after-recurrence of patients with local recurrent esophageal cancer.

语种: 英语
WOS记录号: WOS:000350728700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58378
Appears in Collections:北京大学第一临床医学院_肿瘤化疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Radiat Oncol, Beijing 100034, Peoples R China
2.Hebei Med Univ, Hosp 4, Dept Radiat Oncol, Shijiazhuang 050011, Hebei, Peoples R China

Recommended Citation:
Zhou, Zhi-guo,Zhen, Chan-jun,Bai, Wen-wen,et al. Salvage radiotherapy in patients with local recurrent esophageal cancer after radical radiochemotherapy[J]. RADIATION ONCOLOGY,2015,10.
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