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学科主题: 药学
题名:
(+)-Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice
作者: Zhu, Dina1,2,3; Wang, Lei1,2,3; Zhou, Qile4,5; Yan, Shijun1; Li, Zhi1,2,3; Sheng, Jun6; Zhang, Wensheng1,2,3
关键词: (+)-Catechin ; db/db mice ; Diabetic nephropathy ; Inflammation ; Methylglyoxal
刊名: MOLECULAR NUTRITION & FOOD RESEARCH
发表日期: 2014-12-01
DOI: 10.1002/mnfr.201400533
卷: 58, 期:12, 页:2249-2260
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology
研究领域[WOS]: Food Science & Technology
关键词[WOS]: GLYCATION END-PRODUCTS ; GREEN TEA CATECHIN ; ENDOTHELIAL DYSFUNCTION ; RENAL DYSFUNCTION ; GLYOXALASE I ; PATHOGENESIS ; GLUCOSE ; RAGE ; INFLAMMATION ; ACTIVATION
英文摘要:

Scope: Accumulation of glycolytic metabolite methylglyoxal (MG) in diabetic kidney is thought to contribute to the pathogenesis of nephropathy, either as a direct toxin or as a precursor for advanced glycation end products (AGEs). Using (+)-catechin (CE), a novel MG trapper, we investigated whether MG trapping is sufficient to prevent the progression of diabetic nephropathy in type 2 diabetic mice.

Methods and results: CE markedly trapped exogenous MG in a time-and dose-dependent manner and formed mono-MG-CE and di-MG-CE adducts, which were characterized by HPLC-ESI-Q-TOFMS. In vivo, CE administration for 16 wk significantly ameliorated renal dysfunction in type 2 diabetic db/db mice, partially due to MG trapping, which in turn inhibited AGEs formation and lowered proinflammatory cytokines, including tumor necrosis factor alpha and IL-1 beta. Similarly, the MG trapping and cellular signaling inhibition effects of CE were observed in human endothelium-derived cells under high glucose conditions.

Conclusion: CE might ameliorate renal dysfunction in diabetic mice as consequences of inhibiting AGEs formation and cutting off inflammatory pathway via MG trapping. Thus, CE may be a potential natural product as an MG scavenger against diabetes-related complications.

语种: 英语
所属项目编号: 81274118 ; 81230010
项目资助者: National Natural Science Foundation of China ; China Pu-erh Tea Research Institute Foundation
WOS记录号: WOS:000345971100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58386
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Beijing Normal Univ, State Key Lab Earth Surface Proc & Resource Ecol, Beijing 100088, Peoples R China
2.Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Chinese, Beijing 100088, Peoples R China
3.Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
4.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
5.Peking Univ, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100871, Peoples R China
6.Yunnan Agr Univ, Key Lab Pu Erh Tea Sci, Minist Educ, Kunming, Peoples R China

Recommended Citation:
Zhu, Dina,Wang, Lei,Zhou, Qile,et al. (+)-Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice[J]. MOLECULAR NUTRITION & FOOD RESEARCH,2014,58(12):2249-2260.
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