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学科主题基础医学
Ganoderma Lucidum Polysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial Oxidative Stress in Type 1 Diabetes
Tie, Lu1,2; Yang, Hong-Qin1,2,5; An, Yu1,2; Liu, Shao-Qiang1,2,6; Han, Jing1,2; Xu, Yan1,2; Hu, Min1,2; Li, Wei-Dong1,2; Chen, Alex F.3,4; Lin, Zhi-Bin1,2; Li, Xue-Jun1,2
关键词Ganoderma lucidum polysaccharide (Gl-PS) Oxidative stress Mitochondria Diabetes Manganese superoxide dismutase (MnSOD) p66Shc Nitrotyrosine
刊名CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
2012
DOI10.1159/000338512
29期:3-4页:583-594
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Physiology
研究领域[WOS]Cell Biology ; Physiology
关键词[WOS]MANGANESE SUPEROXIDE-DISMUTASE ; NITRIC-OXIDE SYNTHASE ; ENDOTHELIAL PROGENITOR CELLS ; MEDIATED NITRATION ; MICE ; INJURY ; EXPRESSION ; P66(SHC) ; DISEASE ; RATS
英文摘要

Background/Aims. Refractory wounds in diabetic patients constitute a serious complication that often leads to amputation with limited treatment regimens. The present study was designed to determine the protective effect of Ganoderma lucidum polysaccharide (Gl-PS) on diabetic wound healing and investigate underlying mechanisms. Methods. Streptozotocin (STZ)-induced type 1 diabetic mice with full-thickness excisional wounds were intragastrically administered with 10, 50 or 250 mg/kg/day of Gl-PS. Results. Gl-PS dose-dependently rescued the delay of wound closure in diabetic mice. 50 and 250 mg/kg/day of Gl-PS treatment significantly increased the mean perfusion rate around the wound in diabetic mice. Diabetic conditions markly increased mitochondrial superoxide anion (O-2(center dot-)) production, nitrotyrosine formation, and inducible nitric oxide synthase (iNOS) activity in wound tissues, which were normalized with Gl-PS treatment. In diabetic wound tissues, the protein level of manganese superoxide dismutase (MnSOD) was unchanged whereas MnSOD activity was inhibited and its nitration was potentiated; Gl-PS administration suppressed MnSOD nitration and increased MnSOD and glutathione peroxidase (GPx) activities. Moreover, Gl-PS attenuated the redox enzyme p66Shc expression and phosphorylation dose-dependently in diabetic mice skin. Conclusion. Gl-PS rescued the delayed wound healing and improved wound angiogenesis in STZ-induced type 1 diabetic mice, at least in part, by suppression of cutaneous MnSOD nitration, p66Shc and mitochondrial oxidative stress. Copyright (C) 2012 S. Karger AG, Basel

语种英语
WOS记录号WOS:000302752600027
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被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58390
专题北京大学基础医学院_药理学系
北京大学医学部管理机构_医学部
北京大学基础医学院
作者单位1.Peking Univ, Inst Syst Biomed, Beijing 100191, Peoples R China
2.Baoshan Chinese Tradit Med Coll, Baoshan, Peoples R China
3.Peking Univ Third Hosp, Beijing, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
5.Univ Pittsburgh, Sch Med, Vasc Med Inst, Dept Surg, Pittsburgh, PA USA
6.Univ Pittsburgh, Sch Med, McGowan Inst Regenerat Med, Pittsburgh, PA USA
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GB/T 7714
Tie, Lu,Yang, Hong-Qin,An, Yu,et al. Ganoderma Lucidum Polysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial Oxidative Stress in Type 1 Diabetes[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2012,29(3-4):583-594.
APA Tie, Lu.,Yang, Hong-Qin.,An, Yu.,Liu, Shao-Qiang.,Han, Jing.,...&Li, Xue-Jun.(2012).Ganoderma Lucidum Polysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial Oxidative Stress in Type 1 Diabetes.CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,29(3-4),583-594.
MLA Tie, Lu,et al."Ganoderma Lucidum Polysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial Oxidative Stress in Type 1 Diabetes".CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 29.3-4(2012):583-594.
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