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学科主题: 基础医学
题名:
Ganoderma Lucidum Polysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial Oxidative Stress in Type 1 Diabetes
作者: Tie, Lu1,2; Yang, Hong-Qin1,2,5; An, Yu1,2; Liu, Shao-Qiang1,2,6; Han, Jing1,2; Xu, Yan1,2; Hu, Min1,2; Li, Wei-Dong1,2; Chen, Alex F.3,4; Lin, Zhi-Bin1,2; Li, Xue-Jun1,2
关键词: Ganoderma lucidum polysaccharide (Gl-PS) ; Oxidative stress ; Mitochondria ; Diabetes ; Manganese superoxide dismutase (MnSOD) ; p66Shc ; Nitrotyrosine
刊名: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
发表日期: 2012
DOI: 10.1159/000338512
卷: 29, 期:3-4, 页:583-594
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Physiology
研究领域[WOS]: Cell Biology ; Physiology
关键词[WOS]: MANGANESE SUPEROXIDE-DISMUTASE ; NITRIC-OXIDE SYNTHASE ; ENDOTHELIAL PROGENITOR CELLS ; MEDIATED NITRATION ; MICE ; INJURY ; EXPRESSION ; P66(SHC) ; DISEASE ; RATS
英文摘要:

Background/Aims. Refractory wounds in diabetic patients constitute a serious complication that often leads to amputation with limited treatment regimens. The present study was designed to determine the protective effect of Ganoderma lucidum polysaccharide (Gl-PS) on diabetic wound healing and investigate underlying mechanisms. Methods. Streptozotocin (STZ)-induced type 1 diabetic mice with full-thickness excisional wounds were intragastrically administered with 10, 50 or 250 mg/kg/day of Gl-PS. Results. Gl-PS dose-dependently rescued the delay of wound closure in diabetic mice. 50 and 250 mg/kg/day of Gl-PS treatment significantly increased the mean perfusion rate around the wound in diabetic mice. Diabetic conditions markly increased mitochondrial superoxide anion (O-2(center dot-)) production, nitrotyrosine formation, and inducible nitric oxide synthase (iNOS) activity in wound tissues, which were normalized with Gl-PS treatment. In diabetic wound tissues, the protein level of manganese superoxide dismutase (MnSOD) was unchanged whereas MnSOD activity was inhibited and its nitration was potentiated; Gl-PS administration suppressed MnSOD nitration and increased MnSOD and glutathione peroxidase (GPx) activities. Moreover, Gl-PS attenuated the redox enzyme p66Shc expression and phosphorylation dose-dependently in diabetic mice skin. Conclusion. Gl-PS rescued the delayed wound healing and improved wound angiogenesis in STZ-induced type 1 diabetic mice, at least in part, by suppression of cutaneous MnSOD nitration, p66Shc and mitochondrial oxidative stress. Copyright (C) 2012 S. Karger AG, Basel

语种: 英语
所属项目编号: 30901803 ; 91129727 ; 81020108031 ; 30973558 ; 30572202 ; 30901815 ; 20090001120046 ; 2009ZX09103-144 ; B07001
项目资助者: National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; Ministry of Science and Technology in China ; Ministry of Education of China
WOS记录号: WOS:000302752600027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58390
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Inst Syst Biomed, Beijing 100191, Peoples R China
2.Baoshan Chinese Tradit Med Coll, Baoshan, Peoples R China
3.Peking Univ Third Hosp, Beijing, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
5.Univ Pittsburgh, Sch Med, Vasc Med Inst, Dept Surg, Pittsburgh, PA USA
6.Univ Pittsburgh, Sch Med, McGowan Inst Regenerat Med, Pittsburgh, PA USA

Recommended Citation:
Tie, Lu,Yang, Hong-Qin,An, Yu,et al. Ganoderma Lucidum Polysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial Oxidative Stress in Type 1 Diabetes[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2012,29(3-4):583-594.
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