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Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease
Zhou, Xu-jie1,2; Lv, Ji-cheng1,2; Bu, Ding-fang3; Yu, Lei1,2; Yang, Yan-rong1,2,4; Zhao, Juan1,2; Cui, Zhao1,2; Yang, Rui1,2; Zhao, Ming-hui1,2; Zhang, Hong1,2
关键词anti-glomerular basement membrane antibody disease copy number variation FCGR3A
刊名INTERNATIONAL IMMUNOLOGY
2010
DOI10.1093/intimm/dxp113
22期:1页:45-51
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]BASEMENT-MEMBRANE DISEASE ; FC-GAMMA RECEPTORS ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; NEPHROTOXIC NEPHRITIS ; GOODPASTURES-SYNDROME ; DEFICIENT MICE ; HUMAN GENOME ; GLOMERULONEPHRITIS ; GENE ; AUTOIMMUNITY
英文摘要

Anti-glomerular basement membrane antibody disease (anti-GBM disease) is a rare disorder characteristic of universally poor outcome. Fc gamma receptors (Fc gamma Rs) play important roles in anti-GBM disease based on evidence from animal models. Copy number variation (CNV) influences disease susceptibility. The Fc gamma Rs genes show CNV, and CNV of the FCGR3B gene is associated with glomerulonephritis in systemic lupus erythematosus and anti-neutrophil cytoplasmic antibody-associated small vasculitis. Here, we investigated CNV of three FCGR genes, including two (FCGR3A and FCGR3B) for activating Fc gamma Rs and one (FCGR2B) for inhibitory Fc gamma R by duplex quantitative real-time PCR. Copy numbers were analyzed by Applied Biosystems CopyCaller Software v1.0. We first demonstrated the distribution of CNV of FCGR3A, FCGR3B and no CNV of FCGR2B in Chinese population (including 47 anti-GBM patients and 146 healthy controls). The frequency of CNV of FCGR3A was observed to be significantly higher than matched healthy controls (27.7 versus 12.3%, P = 0.013, odds ratio 1.21-6.10). Considering previous report about gene knock-out animal models and CNV effect of FCGR3A, we thus propose that CNV in members of FCGR family should have different roles in the pathogenesis of human anti-GBM disease.

语种英语
WOS记录号WOS:000272931000006
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被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58396
专题北京大学第一临床医学院_肾脏内科
北京大学临床肿瘤学院_药剂科
作者单位1.Peking Univ, Inst Nephrol, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Cent Res Inst, Beijing 100034, Peoples R China
4.ShanXi Med Univ, Hosp 2, Div Renal, Taiyuan 030001, Peoples R China
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Zhou, Xu-jie,Lv, Ji-cheng,Bu, Ding-fang,et al. Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease[J]. INTERNATIONAL IMMUNOLOGY,2010,22(1):45-51.
APA Zhou, Xu-jie.,Lv, Ji-cheng.,Bu, Ding-fang.,Yu, Lei.,Yang, Yan-rong.,...&Zhang, Hong.(2010).Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease.INTERNATIONAL IMMUNOLOGY,22(1),45-51.
MLA Zhou, Xu-jie,et al."Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease".INTERNATIONAL IMMUNOLOGY 22.1(2010):45-51.
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