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A new salicylic acid-derivatized kojic acid vanadyl complex: Synthesis, characterization and anti-diabetic therapeutic potential
Wei, Yongbiao; Zhang, Chengyue; Zhao, Pan; Yang, Xiaoda1; Wang, Kui
关键词Vanadium BSOV Diabetes Antioxidants ADMET
刊名JOURNAL OF INORGANIC BIOCHEMISTRY
2011-08-01
DOI10.1016/j.jinorgbio.2011.05.008
105期:8页:1081-1085
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
资助者NSFC ; Major New Medicine Project in Mega-projects of Science Research of China ; NSFC ; Major New Medicine Project in Mega-projects of Science Research of China
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]INDUCED DIABETIC-RATS ; ACTION MECHANISM ; BLOOD-GLUCOSE ; INSULIN ; CHEMISTRY ; AGENT ; BIS(ALLIXINATO)OXOVANADIUM(IV) ; BIS(MALTOLATO)OXOVANADIUM(IV) ; PERMEABILITY ; TOXICITY
英文摘要

The molecular mechanisms of vanadium toxicity suggest that incorporation of antioxidant groups in the structure of vanadium complexes could be a preferable strategy in designing novel hypoglycemic vanadium complexes with proper efficacy and safety. By conjugating a pyrone skeleton to provide a coordination group and antioxidative motifs, we synthesized a novel complex of bis ((5-hydroxy-4-oxo-4 H-pyran-2-yl) methyl 2-hydroxy- benzoatato) oxovanadium (IV) (BSOV). Evaluation of the anti-diabetic effects of BSOV using streptozotocin (STZ)-induced diabetic rats with bis (maltolato) oxovanadium (BMOV) as a positive control showed that BSOV effectively lowered blood glucose level, ameliorated damages of hepatic and renal function in diabetic rats and improved lipid metabolism. The signs of potential alteration of renal function caused by BSOV and BMOV were observed and are discussed. Overall, the experimental results suggest BSOV as a potent hypoglycemic agent and further studies using this strategy for anti-diabetic agents. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
所属项目编号20971008 ; 2009ZX09502-006
资助者NSFC ; Major New Medicine Project in Mega-projects of Science Research of China ; NSFC ; Major New Medicine Project in Mega-projects of Science Research of China
WOS记录号WOS:000292851900011
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58401
Collection北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Labs Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Wei, Yongbiao,Zhang, Chengyue,Zhao, Pan,et al. A new salicylic acid-derivatized kojic acid vanadyl complex: Synthesis, characterization and anti-diabetic therapeutic potential[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2011,105(8):1081-1085.
APA Wei, Yongbiao,Zhang, Chengyue,Zhao, Pan,Yang, Xiaoda,&Wang, Kui.(2011).A new salicylic acid-derivatized kojic acid vanadyl complex: Synthesis, characterization and anti-diabetic therapeutic potential.JOURNAL OF INORGANIC BIOCHEMISTRY,105(8),1081-1085.
MLA Wei, Yongbiao,et al."A new salicylic acid-derivatized kojic acid vanadyl complex: Synthesis, characterization and anti-diabetic therapeutic potential".JOURNAL OF INORGANIC BIOCHEMISTRY 105.8(2011):1081-1085.
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