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学科主题: 药学
题名:
A new salicylic acid-derivatized kojic acid vanadyl complex: Synthesis, characterization and anti-diabetic therapeutic potential
作者: Wei, Yongbiao; Zhang, Chengyue; Zhao, Pan; Yang, Xiaoda1; Wang, Kui
关键词: Vanadium ; BSOV ; Diabetes ; Antioxidants ; ADMET
刊名: JOURNAL OF INORGANIC BIOCHEMISTRY
发表日期: 2011-08-01
DOI: 10.1016/j.jinorgbio.2011.05.008
卷: 105, 期:8, 页:1081-1085
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: INDUCED DIABETIC-RATS ; ACTION MECHANISM ; BLOOD-GLUCOSE ; INSULIN ; CHEMISTRY ; AGENT ; BIS(ALLIXINATO)OXOVANADIUM(IV) ; BIS(MALTOLATO)OXOVANADIUM(IV) ; PERMEABILITY ; TOXICITY
英文摘要:

The molecular mechanisms of vanadium toxicity suggest that incorporation of antioxidant groups in the structure of vanadium complexes could be a preferable strategy in designing novel hypoglycemic vanadium complexes with proper efficacy and safety. By conjugating a pyrone skeleton to provide a coordination group and antioxidative motifs, we synthesized a novel complex of bis ((5-hydroxy-4-oxo-4 H-pyran-2-yl) methyl 2-hydroxy- benzoatato) oxovanadium (IV) (BSOV). Evaluation of the anti-diabetic effects of BSOV using streptozotocin (STZ)-induced diabetic rats with bis (maltolato) oxovanadium (BMOV) as a positive control showed that BSOV effectively lowered blood glucose level, ameliorated damages of hepatic and renal function in diabetic rats and improved lipid metabolism. The signs of potential alteration of renal function caused by BSOV and BMOV were observed and are discussed. Overall, the experimental results suggest BSOV as a potent hypoglycemic agent and further studies using this strategy for anti-diabetic agents. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 20971008 ; 2009ZX09502-006
项目资助者: NSFC ; Major New Medicine Project in Mega-projects of Science Research of China
WOS记录号: WOS:000292851900011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58401
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Labs Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China

Recommended Citation:
Wei, Yongbiao,Zhang, Chengyue,Zhao, Pan,et al. A new salicylic acid-derivatized kojic acid vanadyl complex: Synthesis, characterization and anti-diabetic therapeutic potential[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2011,105(8):1081-1085.
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