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学科主题: 临床医学
题名:
MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3
作者: Fan, Zhongyi1; Cui, Hanzhi2; Xu, Xiaojie3; Lin, Zhi1; Zhang, Xuelin1; Kang, Lei4; Han, Baiyu5; Meng, Jing1; Yan, Zhifeng1; Yan, Xiang1; Jiao, Shunchang1
关键词: miR-125a ; cervical cancer ; cell growth ; metastasis ; STAT3
刊名: ONCOTARGET
发表日期: 2015-09-22
卷: 6, 期:28, 页:25266-25280
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: EPITHELIAL-MESENCHYMAL TRANSITION ; LYMPH-NODE METASTASIS ; HUMAN-PAPILLOMAVIRUS ; BREAST-CANCER ; UNFAVORABLE PROGNOSIS ; GERMLINE MUTATION ; SIGNAL TRANSDUCER ; EXPRESSION ; CARCINOMA ; CELLS
英文摘要:

MiR-125a has been characterized as a tumor suppressor in several cancers. However, the role of miR-125a in cervical cancer is unknown. In this study, we found the expression of miR-125a was downregulated in cervical cancer patients, and negatively correlated with the tumor size, FIGO stage, and preoperative metastasis. Kaplan-Meier analysis showed that miR-125a expression predicted favorable outcome for cervical cancer patients. Dual luciferase assays identified the STAT3 gene as a novel direct target of miR-125a. Functional studies showed that miR-125a overexpression significantly suppressed the growth, invasion and epithelial-mesenchymal transition (EMT) of cervical cancer cells both in vitro and in vivo via decreasing STAT3 expression. Moreover, miR-125a conferred to G2/M cell cycle arrest, accompanied by inhibition of several G2/M checkpoint proteins. Mechanistically, inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression. Clinically, STAT3, the expression of which, predicted poorer outcome, was inversely correlated with miR-125a in cervical cancer. These data highlight the importance of miR-125a in the cell proliferation and progression of cervical cancer, and indicate that miR-125a may be a useful therapeutic target for cervical cancer.

语种: 英语
所属项目编号: 2015MS-010 ; 81472589 ; 31100604 ; Z141102001814055
项目资助者: General Program of 309th Hospital of PLA ; National Natural Science Foundation ; Beijing Nova Program
WOS记录号: WOS:000363160100059
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58403
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

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作者单位: 1.Peoples Liberat Army Gen Hosp, Dept Oncol, Beijing, Peoples R China
2.309th Hosp PLA, Dept Oncol, Beijing, Peoples R China
3.Beijing Inst Biotechnol, Dept Med Mol Biol, Beijing, Peoples R China
4.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100871, Peoples R China
5.264th Hosp PLA, Dept Endocrinol & Metablism, Taiyuan, Shanxi, Peoples R China

Recommended Citation:
Fan, Zhongyi,Cui, Hanzhi,Xu, Xiaojie,et al. MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3[J]. ONCOTARGET,2015,6(28):25266-25280.
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