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Clinical observation of physiological and psychological reactions to electric stimulation of the amygdaloid nucleus and the nucleus accumbens in heroin addicts after detoxification
Fang Jun1; Gu Jian-wen2; Yang Wen-tao2; Qin Xue-ying1; Hu Yong-hua1
关键词the amygdaloid nucleus the nucleus accumbens heroin dependence electric stimulation
刊名CHINESE MEDICAL JOURNAL
2012-01-05
DOI10.3760/cma.j.issn.0366-6999.2012.01.012
125期:1页:63-66
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]DRUG-ADDICTION ; NEUROBIOLOGY ; MOTIVATION ; DEPENDENCE ; MECHANISMS ; NEURONS ; BRAIN
英文摘要

Background Stereotactic surgery has been used to treat heroin abstinence in China since 2000 by ablating the amygdaloid nucleus (AMY) and the nucleus accumbens (NAc), which also provides opportunity to identify the relationship between these nuclei and addiction. Our study aimed to explore the physiological and psychological effects of electrically stimulating the AMY and the NAc in heroin addicts after detoxification by observing changes of heart rate, arterial pressure and occurrence of euphoria similar to heroin induced euphoria.

Methods A total of 70 heroin addicts after detoxification were recruited, and 61 of them were eligible to be given stereotactic surgery for heroin abstinence. The operation was carried out after determining the coordinates of all target nucleuses, and stimulation was performed at the AMY and the NAc solely or jointly. Heart rate, arterial pressure and occurrence of euphoria similar to heroin induced euphoria were recorded and analyzed.

Results The average heat rate was (66 +/- 10) beats/min before electric stimulation, and significantly increased to (84 +/- 14) beats/min during stimulation, and changed to (73 +/- 12) beats/min 10 minutes after stimulation. There was a significant elevation of the average arterial pressure from 83 mmHg before stimulation to 98 mmHg during the stimulation, and it then decreased to 90 mmHg after stimulation. Forty-three of the 61 patients showed intense euphoria similar to heroin induced euphoria. The largest number (118/186) of euphoric responses occurred when the AMY and the NAc were stimulated at the same time. Odds ratio was 5.4 (95% Cl: 2.4-11.9, P <0.0001) to quantify the association. Results from a Logistic regression model showed a positive correlation between unilateral stimulation of either the AMY or NAC and induction of euphoria (OR >1), especially when the left AMY or left NAc was stimulated (P <0.05).

Conclusions Our data are consistent with existing results that the AMY and the NAc are related to addiction. Different roles in drug dependence would be suggested according to the location of the AMY and NAc. Chin Med J 2012;125(1):63-66

语种英语
WOS记录号WOS:000300749400012
项目编号LC03002
资助机构WU Jie-ping Medical Foundation ; General Hospital of Chengdu Military District
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58404
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学临床肿瘤学院_麻醉科
作者单位1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
2.Chinese Peoples Liberat Army Chengdu Mil Dist, Gen Hosp, Dept Neurosurg, Chengdu 610083, Sichuan, Peoples R China
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GB/T 7714
Fang Jun,Gu Jian-wen,Yang Wen-tao,et al. Clinical observation of physiological and psychological reactions to electric stimulation of the amygdaloid nucleus and the nucleus accumbens in heroin addicts after detoxification[J]. CHINESE MEDICAL JOURNAL,2012,125(1):63-66.
APA Fang Jun,Gu Jian-wen,Yang Wen-tao,Qin Xue-ying,&Hu Yong-hua.(2012).Clinical observation of physiological and psychological reactions to electric stimulation of the amygdaloid nucleus and the nucleus accumbens in heroin addicts after detoxification.CHINESE MEDICAL JOURNAL,125(1),63-66.
MLA Fang Jun,et al."Clinical observation of physiological and psychological reactions to electric stimulation of the amygdaloid nucleus and the nucleus accumbens in heroin addicts after detoxification".CHINESE MEDICAL JOURNAL 125.1(2012):63-66.
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