IR@PKUHSC  > 北京大学基础医学院  > 放射医学教研室
学科主题基础医学
GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line
Li, Bo1,2; Cheng, Xiao Liang3; Yang, Ye Peng1; Li, Zai Quan1
关键词breast cancer-initiating cells side population glucose-regulated protein 78KD radiation resistance
刊名ONCOLOGY REPORTS
2013-11-01
DOI10.3892/or.2013.2710
30期:5页:2119-2126
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Oncology
关键词[WOS]SIDE POPULATION ; INITIATING CELLS ; SURVIVAL ; THERAPY ; TUMORS ; CHEMOTHERAPY ; APOPTOSIS
英文摘要

Emerging evidence indicates that breast cancer-initiating cells (CICs) are relatively resistant to radiotherapy; however, the critical mechanisms determining breast CIC resistance to radiation remain elusive. In the present study, a subpopulation of cells displaying characteristics generally attributed to stem cells was identified within the breast cancer cell line MCF-7. This subpopulation displays cancer stem cell features characterized by overexpression of embryonic stem cell markers, high tumorigenic potential following transplantation into BALB/c-nu mice, self-renewal capacity and resistance to ionizing radiation (IR). Moreover, glucose-regulated protein 78KD (GRP78), which was found to play a crucial role in stem cell oncogenesis, was also shown to be overexpressed in this subpopulation. GRP78 is required for the cancer stem-like subpopulation cell resistance to IR, as knockdown of this gene augments the effects of IR, while overexpression of GRP78 increases the radiation resistance of the subpopulation to IR. These findings indicate that GRP78 acts as a potential therapeutic target aimed at tumor-generating subsets of breast cancer cells.

语种英语
所属项目编号30470846
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000324540300015
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58409
Collection北京大学基础医学院_放射医学教研室
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Radiat Med, Beijing 100191, Peoples R China
2.Henan Tradit Chinese Med Coll, Affiliated Hosp 2, Tradit Chinese Med Hosp Henan Prov, Dept Nucl Med, Zhengzhou 450002, Henan, Peoples R China
3.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Pharm, Xian 710061, Shaanxi, Peoples R China
Recommended Citation
GB/T 7714
Li, Bo,Cheng, Xiao Liang,Yang, Ye Peng,et al. GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line[J]. ONCOLOGY REPORTS,2013,30(5):2119-2126.
APA Li, Bo,Cheng, Xiao Liang,Yang, Ye Peng,&Li, Zai Quan.(2013).GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line.ONCOLOGY REPORTS,30(5),2119-2126.
MLA Li, Bo,et al."GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line".ONCOLOGY REPORTS 30.5(2013):2119-2126.
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