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学科主题: 基础医学
题名:
GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line
作者: Li, Bo1,2; Cheng, Xiao Liang3; Yang, Ye Peng1; Li, Zai Quan1
关键词: breast cancer-initiating cells ; side population ; glucose-regulated protein 78KD ; radiation resistance
刊名: ONCOLOGY REPORTS
发表日期: 2013-11-01
DOI: 10.3892/or.2013.2710
卷: 30, 期:5, 页:2119-2126
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SIDE POPULATION ; INITIATING CELLS ; SURVIVAL ; THERAPY ; TUMORS ; CHEMOTHERAPY ; APOPTOSIS
英文摘要:

Emerging evidence indicates that breast cancer-initiating cells (CICs) are relatively resistant to radiotherapy; however, the critical mechanisms determining breast CIC resistance to radiation remain elusive. In the present study, a subpopulation of cells displaying characteristics generally attributed to stem cells was identified within the breast cancer cell line MCF-7. This subpopulation displays cancer stem cell features characterized by overexpression of embryonic stem cell markers, high tumorigenic potential following transplantation into BALB/c-nu mice, self-renewal capacity and resistance to ionizing radiation (IR). Moreover, glucose-regulated protein 78KD (GRP78), which was found to play a crucial role in stem cell oncogenesis, was also shown to be overexpressed in this subpopulation. GRP78 is required for the cancer stem-like subpopulation cell resistance to IR, as knockdown of this gene augments the effects of IR, while overexpression of GRP78 increases the radiation resistance of the subpopulation to IR. These findings indicate that GRP78 acts as a potential therapeutic target aimed at tumor-generating subsets of breast cancer cells.

语种: 英语
所属项目编号: 30470846
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000324540300015
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58409
Appears in Collections:基础医学院_放射医学教研室_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Radiat Med, Beijing 100191, Peoples R China
2.Henan Tradit Chinese Med Coll, Affiliated Hosp 2, Tradit Chinese Med Hosp Henan Prov, Dept Nucl Med, Zhengzhou 450002, Henan, Peoples R China
3.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Pharm, Xian 710061, Shaanxi, Peoples R China

Recommended Citation:
Li, Bo,Cheng, Xiao Liang,Yang, Ye Peng,et al. GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line[J]. ONCOLOGY REPORTS,2013,30(5):2119-2126.
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文件名: GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line.pdf
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