北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 化学生物学系  > 期刊论文
学科主题: 药学
题名:
Enantiomer separation of the four stereoisomers of 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol from Hydnocarpus annamensis by capillary zone electrophoresis with HP-beta-CD as chiral selector
作者: Liu, Yi; Shi, Haiming; Sun, Zhe; Ling, Xiaomei; Tu, Pengfei
关键词: capillary zone electrophoresis ; enantiomer separation ; Hydnocarpus annamensis
刊名: CHROMATOGRAPHIA
发表日期: 2006-10-01
DOI: 10.1365/s10337-006-0050-4
卷: 64, 期:7-8, 页:483-486
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: CYCLODEXTRIN ; ENANTIOSEPARATION ; COMPLEXATION ; BORATE ; FORMULATIONS ; VALIDATION ; RESOLUTION ; DIOLS
英文摘要:

A capillary zone electrophoresis method with HP-beta-CD as chiral selector was established for the chiral separation of four stereoisomers of 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol for the first time, which were isolated from Hydnocarpus annamensis. The effects of chiral selector type and concentration, buffer composition, pH and concentration, and cartridge temperature on the enantioseparation were investigated. A baseline separation of the four stereoisomers was achieved in less than 18 min under the optimized conditions: 40 mmol L-1 Borax-NaOH buffer (pH 10.02) in the presence of 100 mmol L-1 HP-beta-CD at 15 degrees C and 30 kV. The experimental results showed that the method by capillary zone electrophoresis for the separation of four stereoisomers is powerful, sensitive and fast, requires less amounts of reagents, and can be employed as a reliable alternative to other methods.

语种: 英语
WOS记录号: WOS:000241507600018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58416
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut Anal, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Yi,Shi, Haiming,Sun, Zhe,et al. Enantiomer separation of the four stereoisomers of 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol from Hydnocarpus annamensis by capillary zone electrophoresis with HP-beta-CD as chiral selector[J]. CHROMATOGRAPHIA,2006,64(7-8):483-486.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Yi]'s Articles
[Shi, Haiming]'s Articles
[Sun, Zhe]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Yi]‘s Articles
[Shi, Haiming]‘s Articles
[Sun, Zhe]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace