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学科主题: 药学
题名:
Enantiomer separation of the four stereoisomers of 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol from Hydnocarpus annamensis by capillary zone electrophoresis with HP-beta-CD as chiral selector
作者: Liu, Yi; Shi, Haiming; Sun, Zhe; Ling, Xiaomei; Tu, Pengfei
关键词: capillary zone electrophoresis ; enantiomer separation ; Hydnocarpus annamensis
刊名: CHROMATOGRAPHIA
发表日期: 2006-10-01
DOI: 10.1365/s10337-006-0050-4
卷: 64, 期:7-8, 页:483-486
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: CYCLODEXTRIN ; ENANTIOSEPARATION ; COMPLEXATION ; BORATE ; FORMULATIONS ; VALIDATION ; RESOLUTION ; DIOLS
英文摘要:

A capillary zone electrophoresis method with HP-beta-CD as chiral selector was established for the chiral separation of four stereoisomers of 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol for the first time, which were isolated from Hydnocarpus annamensis. The effects of chiral selector type and concentration, buffer composition, pH and concentration, and cartridge temperature on the enantioseparation were investigated. A baseline separation of the four stereoisomers was achieved in less than 18 min under the optimized conditions: 40 mmol L-1 Borax-NaOH buffer (pH 10.02) in the presence of 100 mmol L-1 HP-beta-CD at 15 degrees C and 30 kV. The experimental results showed that the method by capillary zone electrophoresis for the separation of four stereoisomers is powerful, sensitive and fast, requires less amounts of reagents, and can be employed as a reliable alternative to other methods.

语种: 英语
WOS记录号: WOS:000241507600018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58416
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut Anal, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Yi,Shi, Haiming,Sun, Zhe,et al. Enantiomer separation of the four stereoisomers of 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol from Hydnocarpus annamensis by capillary zone electrophoresis with HP-beta-CD as chiral selector[J]. CHROMATOGRAPHIA,2006,64(7-8):483-486.
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