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Enantiomer separation of the four stereoisomers of 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol from Hydnocarpus annamensis by capillary zone electrophoresis with HP-beta-CD as chiral selector
Liu, Yi; Shi, Haiming; Sun, Zhe; Ling, Xiaomei; Tu, Pengfei
关键词capillary zone electrophoresis enantiomer separation Hydnocarpus annamensis
刊名CHROMATOGRAPHIA
2006-10-01
DOI10.1365/s10337-006-0050-4
64期:7-8页:483-486
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]CYCLODEXTRIN ; ENANTIOSEPARATION ; COMPLEXATION ; BORATE ; FORMULATIONS ; VALIDATION ; RESOLUTION ; DIOLS
英文摘要

A capillary zone electrophoresis method with HP-beta-CD as chiral selector was established for the chiral separation of four stereoisomers of 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol for the first time, which were isolated from Hydnocarpus annamensis. The effects of chiral selector type and concentration, buffer composition, pH and concentration, and cartridge temperature on the enantioseparation were investigated. A baseline separation of the four stereoisomers was achieved in less than 18 min under the optimized conditions: 40 mmol L-1 Borax-NaOH buffer (pH 10.02) in the presence of 100 mmol L-1 HP-beta-CD at 15 degrees C and 30 kV. The experimental results showed that the method by capillary zone electrophoresis for the separation of four stereoisomers is powerful, sensitive and fast, requires less amounts of reagents, and can be employed as a reliable alternative to other methods.

语种英语
WOS记录号WOS:000241507600018
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58416
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut Anal, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Liu, Yi,Shi, Haiming,Sun, Zhe,et al. Enantiomer separation of the four stereoisomers of 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol from Hydnocarpus annamensis by capillary zone electrophoresis with HP-beta-CD as chiral selector[J]. CHROMATOGRAPHIA,2006,64(7-8):483-486.
APA Liu, Yi,Shi, Haiming,Sun, Zhe,Ling, Xiaomei,&Tu, Pengfei.(2006).Enantiomer separation of the four stereoisomers of 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol from Hydnocarpus annamensis by capillary zone electrophoresis with HP-beta-CD as chiral selector.CHROMATOGRAPHIA,64(7-8),483-486.
MLA Liu, Yi,et al."Enantiomer separation of the four stereoisomers of 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol from Hydnocarpus annamensis by capillary zone electrophoresis with HP-beta-CD as chiral selector".CHROMATOGRAPHIA 64.7-8(2006):483-486.
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