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Is FCGR2A a susceptibility gene to systemic lupus erythematosus in Chinese?
Zhou, X. J.1,2; Lv, J. C.1,2; Qin, L. X.1,2; Yang, H. Z.3; Yu, F.1,2; Zhao, M. H.1,2; Zhang, H.1,2
关键词CNV dosage effect FCGR2A131H/R meta analysis
刊名LUPUS
2011-10-01
DOI10.1177/0961203311409269
20期:11页:1198-1202
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]GAMMA RECEPTOR-IIA ; GENOME-WIDE ASSOCIATION ; COPY NUMBER VARIATION ; DISEASE ; POLYMORPHISM ; LOCI ; REPLICATION ; POPULATION ; VARIANTS ; SLE
英文摘要

Recent genome-wide association scans and replication studies reinforce that FCGR2A is a susceptibility gene in systemic lupus erythematosus (SLE) in Caucasians. However, previous case control studies denied such conclusions in Chinese people. Besides genetic heterogeneity among different ethnicities, copy number variation (CNV), non-homogenous phenotypes and insufficient power may be confounders. We performed a case control study with 1066 Chinese (589 SLE patients and 477 healthy controls) and a meta-analysis based on 2328 SLE patients and 2313 healthy controls. FCGR2A CNV and FCGR2A131H/R [rs1801274] were detected by TaqMan assays. No variation of copy numbers of FCGR2A gene was found in Chinese. A further case control study suggested a dose-response character for FCGR2A131H/R and it affected disease activity, severity and prognosis. Finally, meta-analysis indicated FCGR2A that was a susceptibility gene to SLE in Chinese with an odds ratio of 1.094 and population attributable risk proportion of (PARP) 0.031. By an integrative strategy, we validate that FCGR2A bears no population-specific CNV. FCGR2A131H/R contributes to SLE susceptibility in Chinese, and affects disease activity, severity and prognosis. The undetected association in Chinese derives from under-power rather than any methodological obstacle due to CNV or population-specific genetic effect. Lupus (2011) 20, 1198-1202.

语种英语
WOS记录号WOS:000295688800013
项目编号30801022 ; 30825021 ; 200802052
资助机构National Natural Science Foundation of China ; Foundation of Ministry of Health of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58417
专题北京大学第一临床医学院_肾脏内科
作者单位1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Univ, Div Renal, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
3.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100034, Peoples R China
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GB/T 7714
Zhou, X. J.,Lv, J. C.,Qin, L. X.,et al. Is FCGR2A a susceptibility gene to systemic lupus erythematosus in Chinese?[J]. LUPUS,2011,20(11):1198-1202.
APA Zhou, X. J..,Lv, J. C..,Qin, L. X..,Yang, H. Z..,Yu, F..,...&Zhang, H..(2011).Is FCGR2A a susceptibility gene to systemic lupus erythematosus in Chinese?.LUPUS,20(11),1198-1202.
MLA Zhou, X. J.,et al."Is FCGR2A a susceptibility gene to systemic lupus erythematosus in Chinese?".LUPUS 20.11(2011):1198-1202.
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