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学科主题基础医学
Pleiotropic Effects of Peroxisome Proliferator-Activated Receptor gamma and delta in Vascular Diseases
Cheang, Wai San1,2; Fang, Xi3; Tian, Xiao Yu1,2,4
关键词Atherosclerosis Endothelial function Peroxisome proliferator-activated receptors Vasculature
刊名CIRCULATION JOURNAL
2013-11-01
DOI10.1253/circj.CJ-13-0647
77期:11页:2664-2671
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]SMOOTH-MUSCLE-CELLS ; ENDOTHELIAL PROGENITOR CELLS ; RETINOID-X-RECEPTOR ; INFLAMMATORY ADHESION MOLECULES ; REDUCES OXIDATIVE STRESS ; LOWERS BLOOD-PRESSURE ; PROTEIN-KINASE-C ; E-DEFICIENT MICE ; PPAR-GAMMA ; DIABETIC MICE
英文摘要

Peroxisome proliferator-activated receptors gamma (PPAR gamma) and delta (PPAR delta) are nuclear receptors that have significant physiological effects on glucose and lipid metabolism. Experimental studies in animal models of metabolic disease have demonstrated their effects on improving lipid profile, insulin sensitivity, and reducing inflammatory responses. PPAR gamma and -delta are also expressed in the vasculature and their beneficial effects have been examined in various cardiovascular disease models such as atherosclerosis, hypertension, diabetic vascular complications, etc. using pharmacological ligands or genetic tools including viral vectors and transgenic mice. These studies suggest that PPAR gamma and delta are antiinflammatory, antiatherogenic, antioxidant, and antifibrotic against vascular diseases. Several signaling pathways, effector molecules, as well as coactivators/repressors have been identified as responsible for the protective effects of PPAR gamma and -delta in the vasculature. We discuss the pleiotropic effect of PPAR gamma and 6 in vascular dysfunction, including atherosclerosis, hypertension, vascular remodeling, vascular injury, and diabetic vasculopathy, in various animal models, and the major underlying mechanisms. We also compare the phenotypes-of several endothelial cell/vascular smooth muscle-specific PPAR gamma and -delta knockout and overexpressing transgenic mice in various disease models, and the implications underlying the functional importance of vascular PPAR gamma and delta in regulating whole-body homeostasis.

语种英语
WOS记录号WOS:000326317600003
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58421
专题北京大学基础医学院_心血管所
作者单位1.Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA
2.Chinese Univ Hong Kong, Inst Vasc Med, Hong Kong, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100871, Peoples R China
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Cheang, Wai San,Fang, Xi,Tian, Xiao Yu. Pleiotropic Effects of Peroxisome Proliferator-Activated Receptor gamma and delta in Vascular Diseases[J]. CIRCULATION JOURNAL,2013,77(11):2664-2671.
APA Cheang, Wai San,Fang, Xi,&Tian, Xiao Yu.(2013).Pleiotropic Effects of Peroxisome Proliferator-Activated Receptor gamma and delta in Vascular Diseases.CIRCULATION JOURNAL,77(11),2664-2671.
MLA Cheang, Wai San,et al."Pleiotropic Effects of Peroxisome Proliferator-Activated Receptor gamma and delta in Vascular Diseases".CIRCULATION JOURNAL 77.11(2013):2664-2671.
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