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学科主题: 基础医学
题名:
Pleiotropic Effects of Peroxisome Proliferator-Activated Receptor gamma and delta in Vascular Diseases
作者: Cheang, Wai San1,2; Fang, Xi3; Tian, Xiao Yu1,2,4
关键词: Atherosclerosis ; Endothelial function ; Peroxisome proliferator-activated receptors ; Vasculature
刊名: CIRCULATION JOURNAL
发表日期: 2013-11-01
DOI: 10.1253/circj.CJ-13-0647
卷: 77, 期:11, 页:2664-2671
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: SMOOTH-MUSCLE-CELLS ; ENDOTHELIAL PROGENITOR CELLS ; RETINOID-X-RECEPTOR ; INFLAMMATORY ADHESION MOLECULES ; REDUCES OXIDATIVE STRESS ; LOWERS BLOOD-PRESSURE ; PROTEIN-KINASE-C ; E-DEFICIENT MICE ; PPAR-GAMMA ; DIABETIC MICE
英文摘要:

Peroxisome proliferator-activated receptors gamma (PPAR gamma) and delta (PPAR delta) are nuclear receptors that have significant physiological effects on glucose and lipid metabolism. Experimental studies in animal models of metabolic disease have demonstrated their effects on improving lipid profile, insulin sensitivity, and reducing inflammatory responses. PPAR gamma and -delta are also expressed in the vasculature and their beneficial effects have been examined in various cardiovascular disease models such as atherosclerosis, hypertension, diabetic vascular complications, etc. using pharmacological ligands or genetic tools including viral vectors and transgenic mice. These studies suggest that PPAR gamma and delta are antiinflammatory, antiatherogenic, antioxidant, and antifibrotic against vascular diseases. Several signaling pathways, effector molecules, as well as coactivators/repressors have been identified as responsible for the protective effects of PPAR gamma and -delta in the vasculature. We discuss the pleiotropic effect of PPAR gamma and 6 in vascular dysfunction, including atherosclerosis, hypertension, vascular remodeling, vascular injury, and diabetic vasculopathy, in various animal models, and the major underlying mechanisms. We also compare the phenotypes-of several endothelial cell/vascular smooth muscle-specific PPAR gamma and -delta knockout and overexpressing transgenic mice in various disease models, and the implications underlying the functional importance of vascular PPAR gamma and delta in regulating whole-body homeostasis.

语种: 英语
WOS记录号: WOS:000326317600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58421
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Houston Methodist Res Inst, Dept Cardiovasc Sci, Houston, TX 77030 USA
2.Chinese Univ Hong Kong, Inst Vasc Med, Hong Kong, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100871, Peoples R China

Recommended Citation:
Cheang, Wai San,Fang, Xi,Tian, Xiao Yu. Pleiotropic Effects of Peroxisome Proliferator-Activated Receptor gamma and delta in Vascular Diseases[J]. CIRCULATION JOURNAL,2013,77(11):2664-2671.
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