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学科主题: 临床医学
题名:
Malignant placental site trophoblastic tumor - A cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization
作者: Xue, WC; Guan, XY; Ngan, HYS; Shen, DH; Khoo, US; Cheung, ANY
关键词: placental site trophoblastic tumor ; comparative genomic hybridization ; chromosome in situ hybridization ; cytogenetic study
刊名: CANCER
发表日期: 2002-04-15
DOI: 10.1002/cncr.10424
卷: 94, 期:8, 页:2288-2294
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ENDOMETRIAL STROMAL SARCOMA ; SQUAMOUS-CELL CARCINOMA ; INTERMEDIATE TROPHOBLAST ; HYDATIDIFORM MOLES ; PARAFFIN SECTIONS ; DNA ANALYSIS ; NUCLEAR-DNA ; CHORIOCARCINOMA ; PSEUDOTUMOR ; ABERRATIONS
英文摘要:

BACKGROUND. Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasm composed predominantly of intermediate trophoblast. Most showed benign behavior whereas 10-15% of PSTTs were clinically malignant with later recurrence and metastasis. Currently, there are no reliable means to predict clinical outcome, and cytogenetic information is scanty.

METHODS. The clinicopathologic features of two cases of malignant PSTT were analyzed. Cytogenetic analysis was performed by comparative genomic hybridization (CGH) and chromosome in situ hybridization (CISH) using frozen tissue and paraffin embedded sections, respectively.

RESULTS. Both patients were 32 years old at time of diagnosis. One patient with PSTT presented with menorrhagia, and the other presented with symptoms of missed abortion. Elevated serum human chorionic gonadotropin (HCG) was detected in both patients. Histologic examination showed the typical features of PSTT with high mitotic count (> 5/10 high-power fields). Ovarian and lung metastasis occurred in both patients. Immunohistochemical staining revealed an equal distribution of HCG and human placental lactogen. Cytogenetic studies by CISH showed that karyotypes of these two malignant PSTTs were diploid. Analysis of the turner tissue by CGH did not show any changes in DNA copy numbers.

CONCLUSIONS. The authors′ study indicated that the two metastasizing PSTTs had balanced diploid karyotype. The malignant behavior of PSTTs may be not related to the DNA copy number changes. Such cytogenetic study may be useful in distinguishing metastatic PSTT from choriocarcinoma. (C) 2002 American Cancer Society.

语种: 英语
WOS记录号: WOS:000175062700023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58422
Appears in Collections:北京大学第二临床医学院_病理科_期刊论文

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作者单位: 1.Univ Hong Kong, Dept Pathol, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100871, Peoples R China
3.Univ Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
4.Univ Hong Kong, Queen Mary Hosp, Dept Obstet & Gynecol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Xue, WC,Guan, XY,Ngan, HYS,et al. Malignant placental site trophoblastic tumor - A cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization[J]. CANCER,2002,94(8):2288-2294.
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