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A preliminary investigation of EZSCAN (TM) screening for impaired glucose tolerance and diabetes in a patient population
Chen, Xiaolu1; Chen, Lizhu2,3; Ding, Rongjing4; Shi, Qiuting5; Zhang, Yuanyuan1; Hu, Dayi6
关键词EZSCAN (TM) impaired glucose tolerance diabetes Chinese
刊名EXPERIMENTAL AND THERAPEUTIC MEDICINE
2015-05-01
DOI10.3892/etm.2015.2358
9期:5页:1688-1694
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]GLYCATED HEMOGLOBIN ; LIFE-STYLE ; MELLITUS ; CHINESE ; PREVENTION ; DIAGNOSIS ; CRITERIA ; TOOL
英文摘要

EZSCAN (TM) is a non-invasive technology that evaluates sweat gland dysfunction using electrochemical skin conductance measurements, providing an opportunity to determine the risk of impaired glucose tolerance (IGT) and diabetes mellitus (DM). This study was conducted with the aims of detecting IGT and DM and investigating the efficacy and cut-off points of the EZSCAN test in a patient population. The traditional serum and plasma glucose tests were used as comparators. In this cross-sectional study, 270 previously undiagnosed patients (180 women and 90 men) with a high risk of glucose metabolism disorders (>= 45 years old) were enrolled. All patients underwent an oral glucose tolerance test (OGTT) and hemoglobin A1c (HbA1c), fasting plasma glucose (FPG) and EZSCAN tests. Forty (14.8%) patients had newly diagnosed DM (NDM), 79 (29.3%) had IGT and 151 (55.9%) had normal glucose tolerance. The EZSCAN values of these groups were 48 +/- 11, 47 +/- 11 and 34 +/- 13%, respectively. For all patients, the correlation coefficient of EZSCAN was 0.462 with the OGTT (P<0.001), 0.182 with the FPG test (P<0.001) and 0.379 with the HbA lc test (P<0.001). The EZSCAN cut-off point for the detection of IGT was 37% [sensitivity, 82%; specificity, 62%; area under the curve (AUC), 0.778], and the cut-off point for NDM was 50% (sensitivity, 53%; specificity, 59%; AUC, 0.528). This study demonstrated that the non-invasive EZSCAN system is an effective screening tool for the detection of glucose dysfunction in the population tested, and that its performance in detecting previously undiagnosed IGT is superior to its performance in detecting DM.

语种英语
WOS记录号WOS:000353849700021
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58426
专题北京大学第二临床医学院_心血管内科
作者单位1.Sichuan Prov Peoples Hosp, Chengdu 610072, Sichuan, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
3.Chongqing Int Sci & Technol Cooperat Ctr Child De, Key Lab Pediat Chongqing, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400016, Sichuan, Peoples R China
4.Sichuan Acad Med Sci, Dept Cardiol, Chengdu 610072, Sichuan, Peoples R China
5.Xianghe Community Hosp, Dept Internal Med, Xianghe 065400, Hebei, Peoples R China
6.Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Sichuan, Peoples R China
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GB/T 7714
Chen, Xiaolu,Chen, Lizhu,Ding, Rongjing,et al. A preliminary investigation of EZSCAN (TM) screening for impaired glucose tolerance and diabetes in a patient population[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2015,9(5):1688-1694.
APA Chen, Xiaolu,Chen, Lizhu,Ding, Rongjing,Shi, Qiuting,Zhang, Yuanyuan,&Hu, Dayi.(2015).A preliminary investigation of EZSCAN (TM) screening for impaired glucose tolerance and diabetes in a patient population.EXPERIMENTAL AND THERAPEUTIC MEDICINE,9(5),1688-1694.
MLA Chen, Xiaolu,et al."A preliminary investigation of EZSCAN (TM) screening for impaired glucose tolerance and diabetes in a patient population".EXPERIMENTAL AND THERAPEUTIC MEDICINE 9.5(2015):1688-1694.
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