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学科主题: 基础医学
题名:
Fangchinoline inhibits rat aortic vascular smooth muscle cell proliferation and cell cycle progression through inhibition of ERK1/2 activation and c-fos expression
作者: Zhang, YH; Fang, LH; Ku, BS
关键词: fangchinoline ; aortic smooth muscle cells ; MAP kinase ; cell cycle ; proliferation ; c-fos
刊名: BIOCHEMICAL PHARMACOLOGY
发表日期: 2003-11-01
DOI: 10.1016/S0006-2952(03)00550-1
卷: 66, 期:9, 页:1853-1860
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: GROWTH-FACTOR ; TETRANDRINE ; MIGRATION ; ATHEROSCLEROSIS
英文摘要:

Fangchinoline (FAN; a plant alkaloid isolated from Stephania tetrandrae) is a nonspecific Ca2+ channel blocker. The objective of the present study was to investigate the effect of FAN on the growth factor-induced proliferation of primary cultured rat aortic smooth muscle cells (RASMCs). FAN significantly inhibited both 5% fetal bovine serum (FBS)- and 50 ng/mL platelet-derived growth factor (PDGF)-BB-induced proliferation, [H-3]thymidine incorporation into DNA and phosphorylation of extracellular signal-regulated kinase 1/2. In accordance with these findings, FAN revealed blocking of the FBS-inducible progression through G(0)/G(1) to S phase of the cell cycle in synchronized cells and caused a 62% decrease in the early elevation of c-fos expression induced after 5% FBS addition. Furthermore, significant antiproliferative activity of FAN is observed at concentrations below those required to achieve significant inhibition of Ca2+ channels by FAN. These results suggest that FAN reduced both FBS- and PDGF-BB-induced RASMCs proliferation by perturbing cell cycle progression. This antiproliferative effect of FAN is dependent on the MAP kinase pathway, but cannot be limited to its Ca2+ modulation. (C) 2003 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000186219800018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58432
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100871, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing, Peoples R China

Recommended Citation:
Zhang, YH,Fang, LH,Ku, BS. Fangchinoline inhibits rat aortic vascular smooth muscle cell proliferation and cell cycle progression through inhibition of ERK1/2 activation and c-fos expression[J]. BIOCHEMICAL PHARMACOLOGY,2003,66(9):1853-1860.
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