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学科主题: 临床医学
题名:
Correlation of localized glaucomatous visual field defects and spectral domain optical coherence tomography retinal nerve fiber layer thinning using a modified structure-function map for OCT
作者: Wu, H.1,2,3; de Boer, J. F.4; Chen, L.5,6; Chen, T. C.1
刊名: EYE
发表日期: 2015-04-01
DOI: 10.1038/eye.2014.317
卷: 29, 期:4, 页:525-533
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: SCANNING LASER POLARIMETRY ; OCULAR HYPERTENSION TREATMENT ; STANDARD AUTOMATED PERIMETRY ; GDX-VCC ; THICKNESS ; SENSITIVITY ; EYES ; ASSOCIATION ; PARTICIPANTS ; DISC
英文摘要:

Purpose To study the correlation between glaucomatous visual field (VF) defects assessed by standard automated perimetry (SAP) and peripapillary retinal nerve fiber layer (RNFL) thinning measured by spectral domain optical coherence tomography (OCT) using a modified OCT-based peripapillary RNFL structure-function map.

Patients and methods Perimetric glaucoma patients and age-matched normal control subjects were recruited from a university hospital clinic. All eyes underwent testing with the Spectralis spectral domain OCT and SAP on the same day. An OCT-based correspondence map, which correlated VF areas with peripapillary RNFL sectors was created to evaluate the relationship between glaucomatous RNFL thinning and VF loss in six nerve fiber layer bundle areas. Correlations of RNFL thinning with corresponding VF defects were examined using Spearman rank-order correlations. To demonstrate the association between localized VF defects and RNFL thickness, the theoretical curves were made according to an established log-linear model. The measured RNFL thickness values and VF defects were presented in the same scatterplot for each sector.

Results Fifty-six glaucoma patients and 85 normal subjects were included in the study. Significant association between localized VF loss and RNFL thinning was found in corresponding areas. Data from the current study fit well with established log-linear models, which compare RNFL thickness values with VF defects.

Conclusion Analysis of RNFL thinning in eyes with localized glaucomatous VF defects showed good structure-function correlation in a new OCT-based structure-function correspondence map.

语种: 英语
所属项目编号: R01 EY14975-01
项目资助者: National Institutes of Health
WOS记录号: WOS:000352627400013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58435
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Harvard Univ, Sch Med, Dept Ophthalmol, Massachusetts Eye & Ear Infirm,Glaucoma Serv, Boston, MA 02114 USA
3.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100871, Peoples R China
4.Vrije Univ Amsterdam, Dept Phys & Astron, Amsterdam, Netherlands
5.Fudan Univ, Eye & ENT Hosp, Dept Ophthalmol & Vis Sci, Shanghai Med Sch, Shanghai 200433, Peoples R China
6.Univ Hong Kong, Dept Ophthalmol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Wu, H.,de Boer, J. F.,Chen, L.,et al. Correlation of localized glaucomatous visual field defects and spectral domain optical coherence tomography retinal nerve fiber layer thinning using a modified structure-function map for OCT[J]. EYE,2015,29(4):525-533.
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