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学科主题: 基础医学
题名:
Systemic cytokine profiles and splenic toll-like receptor expression during Trichinella spiralis infection
作者: Yu, Yan-Rong1; Deng, Ming-Jun2; Lu, Wei-Wei1; Jia, Mo-Zhi1; Wu, Wei1; Qi, Yong-Fen1,3,4
关键词: Trichinella spiralis ; Th1/Th2 ; Toll-like receptor ; Helminth ; Immune modulation
刊名: EXPERIMENTAL PARASITOLOGY
发表日期: 2013-05-01
DOI: 10.1016/j.exppara.2013.02.014
卷: 134, 期:1, 页:92-101
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Parasitology
研究领域[WOS]: Parasitology
关键词[WOS]: INTESTINAL NEMATODE PARASITES ; REGULATORY T-CELLS ; HELMINTH-PARASITES ; DENDRITIC CELLS ; IMMUNE-RESPONSE ; IN-VITRO ; ACTIVATION ; PRODUCTS ; IL-10 ; INHIBITION
英文摘要:

Parasitic helminth and their products can suppress or modulate the host immune response for long-term survival and continued infection. Commonly, helminth can induce conditional T helper cell type 2 (Th2) response, regulatory T cell and cytokines, and altered function of antigen presentation cells by modulating toll-like receptors (TLRs). The helminth Trichinella spiralis establishes chronic infection in skeletal muscles of a wide range of mammalian hosts. We infected mice with T. spiralis and investigated Th1/Th2/Th17 cytokine profiles in serum and expression of TLRs and related signal molecules in spleen at various times post-infection. The infection evoked a mixed Th1/Th2 and inhibited Th17 immune response, with initial predominance of a Th1 response in intestine stage and subsequent predominance of a Th2 response in muscle stage. Different stages of infection had different impacts on the expression of TLRs and related signaling molecules. In the adult stage of infection, TLR1 and TLR4 were upregulated and the MyD88-dependent signal pathway was activated. The muscle larvae inhibited TLR4 and TRIP-dependent signal pathway. Our results implied that T. spiralis infection may regulate Th1/Th2/Th17 cytokine production through TLRs. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30901247 ; 201110039
项目资助者: National Natural Science Foundation of China ; National Quality Inspection Public welfare Scientific Research Project ; Leading Academic Discipline Project of Beijing Education Bureau
WOS记录号: WOS:000317539000014
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58440
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathogen Biol, Beijing 100191, Peoples R China
3.Shandong Entry Exit Inspect & Quarantine Bur, Ctr Tech, Qingdao 266002, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Lab Cardiovasc Bioact Mol, Beijing 100191, Peoples R China

Recommended Citation:
Yu, Yan-Rong,Deng, Ming-Jun,Lu, Wei-Wei,et al. Systemic cytokine profiles and splenic toll-like receptor expression during Trichinella spiralis infection[J]. EXPERIMENTAL PARASITOLOGY,2013,134(1):92-101.
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