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Multi-element distribution profile in Sprague-Dawley rats: Effects of intratracheal instillation of Cr(VI) and Zn intervention
Song, Yanshuang; Wang, Tianjing; Pu, Ji; Guo, Jian; Chen, Zhangjian; Wang, Yun; Jia, Guang
关键词Element homeostasis Hexavalent chromium [Cr(VI)] Oxidative stress SD rat Zinc interventiona
刊名TOXICOLOGY LETTERS
2014-04-21
DOI10.1016/j.toxlet.2014.02.008
226期:2页:198-205
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]RED-BLOOD-CELLS ; OXIDATIVE STRESS ; ZINC-DEFICIENCY ; LUNG-CANCER ; DNA-DAMAGE ; CHROMIUM ; SUPPLEMENTATION ; MICE ; TOXICITY ; PROTEINS
英文摘要

Our previous epidemiological study revealed that co-exposure of [Cr(VI)] with small amount of heavymetals could induce peripheral blood element imbalance, but little was known about the contributionof Cr(VI) itself and the multi-element distribution profile in other target tissues. We explored elementhomeostasis in the blood, RBC, serum and lung after Cr(VI) exposure and Zn intervention. 60 SpragueDawley male rats received intratracheal instillation of Cr(VI) (0, 0.063, 0.630 mg Cr/kg) weekly and/orintragastric administration of zinc sulfate (0, 10 mg Zn/kg) daily for one month. Element contents andurinary 8-hydroxy-2 similar to -deoxyguanosine (8-OHdG) concentrations were determined. Dose-response relationship was observed among rats exposed to Cr(VI). Ca, Mg, Mn in the blood, Fe, Mg, Se in the serum, andMg and Zn in lung tissue decreased significantly, while Ca, Co, Cr, Mg, Mn, Se in RBC, and Ca, Co, Mo inthe lung increased after Cr(VI) exposure. The alteration trends manifested differently, with RBC the mostsensitive. Cr induced increase of urinary 8-OHdG, which decreased after Zn intervention. Zn interventioncould help to restore element homeostasis after Cr(VI) exposure, especially for Ca, Fe, Mg and Se. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000333247100011
项目编号81072281 ; 81273043
资助机构National NaturalScience Foundation of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58443
专题北京大学公共卫生学院
北京大学医学部管理机构_科学研究处
北京大学公共卫生学院_公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Song, Yanshuang,Wang, Tianjing,Pu, Ji,et al. Multi-element distribution profile in Sprague-Dawley rats: Effects of intratracheal instillation of Cr(VI) and Zn intervention[J]. TOXICOLOGY LETTERS,2014,226(2):198-205.
APA Song, Yanshuang.,Wang, Tianjing.,Pu, Ji.,Guo, Jian.,Chen, Zhangjian.,...&Jia, Guang.(2014).Multi-element distribution profile in Sprague-Dawley rats: Effects of intratracheal instillation of Cr(VI) and Zn intervention.TOXICOLOGY LETTERS,226(2),198-205.
MLA Song, Yanshuang,et al."Multi-element distribution profile in Sprague-Dawley rats: Effects of intratracheal instillation of Cr(VI) and Zn intervention".TOXICOLOGY LETTERS 226.2(2014):198-205.
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