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学科主题: 临床医学
题名:
Stroke prevention in atrial fibrillation-An Asian stroke perspective
作者: Tse, Hung-Fat1; Wang, Yong-Jun2; Ai-Abdullah, Moheeb Ahmed3; Pizarro-Borromeo, Annette B.4; Chiang, Chern-En5,6; Krittayaphong, Rungroj7; Singh, Balbir8; Vora, Amit9; Wang, Chun-Xue2; Zubaid, Mohammad10; Clemens, Andreas11; Lim, Paul12; Hu, Dayi13
关键词: Atrial fibrillation ; Asia ; Stroke prevention
刊名: HEART RHYTHM
发表日期: 2013-07-01
DOI: 10.1016/j.hrthm.2013.03.017
卷: 10, 期:7, 页:1082-1088
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: FACTOR XA INHIBITOR ; INTERNATIONAL NORMALIZED RATIO ; ACUTE ISCHEMIC-STROKE ; RE-LY TRIAL ; J-ROCKET AF ; JAPANESE PATIENTS ; RISK-FACTORS ; WARFARIN THERAPY ; RACIAL/ETHNIC DIFFERENCES ; DABIGATRAN ETEXILATE
英文摘要:

Despite relatively lower prevalence of atrial fibrillation (AF) in Asians (similar to 1%) than in Caucasians (similar to 2%), Asia has a much higher overall disease burden because of its proportionally larger aged population. For example, on the basis of reported age-adjusted prevalence rates and projected population figures in China, there will be an estimated 5.2 million men and 3.1 million women with AF older than 60 years by year 2050. Stroke is a disabling complication of AF that is of increasing cause for concern in Asians patients. Implementing consensus expert recommendations for managing stroke risk in patients with AF can considerably reduce stroke rates. However, caution is necessary when aligning management of Asian patients with AF to that of their Caucasian counterparts. Current international guidelines and risk stratification tools for AF management are based on findings in predominantly Caucasian populations and may therefore have limited relevance, in certain respects, to Asian patients. Oral anticoagulants play an important role in preventing AF-related stroke. The vitamin K antagonist warfarin is recommended for reducing the risk of stroke and thromboembolism in high-risk patients with nonvalvular AF; however, warfarin interacts with many drugs and food ingredients, which may pose significant challenges in administration and monitoring among Asian patients. Further research is needed to inform specific guidance on the implications of different stroke and bleeding profiles in Asians vs Caucasians. Moreover, there is scope to improve physician perceptions and patient knowledge, as well as considering alternative new oral anticoagulants, for example, direct thrombin inhibitors or factor Xa inhibitors.

语种: 英语
项目资助者: Boehringer Ingelheim
WOS记录号: WOS:000321497500027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58450
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Taipei Vet Gen Hosp, Gen Clin Res Ctr, Taipei, Taiwan
2.Natl Yang Ming Univ, Taipei 112, Taiwan
3.Mahidol Univ, Siriraj Hosp, Bangkok 10700, Thailand
4.Medanta Heart Inst, Gurgaon, Haryana, India
5.Arrhythmia Associates, Bombay, Maharashtra, India
6.Prince Sultan Cardiac Ctr, Riyadh, Saudi Arabia
7.Philippine Heart Ctr, Quezon City, Philippines
8.Univ Hong Kong, Dept Med, Div Cardiol, Hong Kong, Hong Kong, Peoples R China
9.Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China
10.Kuwait Univ, Fac Med, Dept Med, Kuwait, Kuwait
11.Boehringer Ingelheim Pharma GmbH & Co KG, Global Clin Dev & Med Affairs, Biberach, Germany
12.Boehringer Ingelheim Singapore Pte Ltd, Singapore, Singapore
13.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Tse, Hung-Fat,Wang, Yong-Jun,Ai-Abdullah, Moheeb Ahmed,et al. Stroke prevention in atrial fibrillation-An Asian stroke perspective[J]. HEART RHYTHM,2013,10(7):1082-1088.
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