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学科主题: 基础医学
题名:
Modulation of cytokines production, granzyme B and perforin in murine CIK cells by Ganoderma lucidum polysaccharides
作者: Zhu, XL; Lin, ZB
关键词: polysaccharides ; cytokine ; perforin ; granzyme B ; antitumour activity ; immunomodulatory
刊名: CARBOHYDRATE POLYMERS
发表日期: 2006-02-03
DOI: 10.1016/j.carbpol.2005.08.002
卷: 63, 期:2, 页:188-197
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]: Chemistry ; Polymer Science
关键词[WOS]: INDUCED KILLER-CELLS ; COMPLEX-UNRESTRICTED CYTOTOXICITY ; PORE-FORMING PROTEIN ; T-CELLS ; INTERFERON-GAMMA ; NITRIC-OXIDE ; LIVER-INJURY ; EXPRESSION ; INDUCTION ; ANTITUMOR
英文摘要:

Ganoderma lucidum polysaccharides (Gl-PS) have shown a variety of immune modulating effects. Culture of immunologic effector cells termed cytokine induced killer (CIK) cells is dependent on exogenous cytokines. It is not known about effects of Gl-PS on cytokine production, perforin and granzyme B expression in CIK cells. We made use of CIK cells as a means to investigate interaction between Gl-PS and cytokines, and explore mechanism of Gl-PS acting on proliferation and anti-tumor activity of CIK cells. The results suggested that Gl-PS (400 or 100 mu g/ml) promoting CIK cells proliferation and cytotoxicity were relevant to enhancing IL-2, TNF production, protein and mRNA expression of granzyme B and perforin in CIK cells through synergizing cytokines in decreasing doses of IL-2 and anti-CD3 by 75 and 50%, and maybe were irrelevant to nitric oxide (NO). These results confirmed that Gl-PS was a promising biological response modifier (BRM) and immune potentiator. (c) 2005 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000235358200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58453
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Zhu, XL,Lin, ZB. Modulation of cytokines production, granzyme B and perforin in murine CIK cells by Ganoderma lucidum polysaccharides[J]. CARBOHYDRATE POLYMERS,2006,63(2):188-197.
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