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学科主题临床医学
Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid Arthritis
Tang, Sumei1; Huang, Heqing1,2; Hu, Fanlei1; Zhou, Wei3; Guo, Jianping1; Jiang, Huirong4; Mu, Rong1; Li, Zhanguo1
刊名CLINICAL & DEVELOPMENTAL IMMUNOLOGY
2013
DOI10.1155/2013/985301
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]ST2 ; RECEPTOR ; CLASSIFICATION ; EXPRESSION ; CYTOKINE ; CRITERIA ; MEMBER
英文摘要

Objectives. IL-33, a newly found cytokine which is involved in joint inflammation, could be blocked by a decoy receptor-sST2. The expression and correlation of IL-33 and sST2 in rheumatoid arthritis (RA) are of great interest. Methods. Synovial fluid (SF) was obtained from 120 RA and 30 osteoarthritis (OA) patients, and paired sera were collected from 54 of these RA patients. The levels of IL-33 and sST2 were measured by ELISA. Results. SF IL-33 was significantly higher in RA than in OA, which was correlated with disease activity score 28, erythrocyte sedimentation rate, rheumatoid factor (RF)-IgM, RF-IgG, glucose phosphate isomerase (GPI), and immunoglobulin. Serum IL-33 was correlated positively with SF IL-33 in RA. Furthermore, it was correlated with RF-IgM and GPI. sST2 was partly detectable in RA (13 out of 54, 24.1%), while not in OA. Serum sST2 in RA had no significant correlation with serum IL-33 or SF IL-33. However, SFs from both RA and OA patients did not express sST2. Conclusions. This study supported that IL-33 played an important role in the local pathogenesis of RA. Considering the tight correlation between IL-33 and clinical features, it may become a new target of local treatment.

语种英语
WOS记录号WOS:000324713800001
项目编号2010CB529104 ; 31170840 ; 81072401
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58463
专题北京大学第二临床医学院
北京大学药学院_化学生物学系
北京大学第二临床医学院_风湿免疫科
作者单位1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Xiamen Univ, Dept Rheumatol & Immunol, Affiliated Hosp 1, Xiamen 361003, Peoples R China
3.Peking Univ, Hosp 1, Dept Rheumatol & Immunol, Beijing 100034, Peoples R China
4.Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G40RE, Lanark, Scotland
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GB/T 7714
Tang, Sumei,Huang, Heqing,Hu, Fanlei,et al. Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid Arthritis[J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY,2013.
APA Tang, Sumei.,Huang, Heqing.,Hu, Fanlei.,Zhou, Wei.,Guo, Jianping.,...&Li, Zhanguo.(2013).Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid Arthritis.CLINICAL & DEVELOPMENTAL IMMUNOLOGY.
MLA Tang, Sumei,et al."Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid Arthritis".CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2013).
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