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学科主题: 临床医学
题名:
Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid Arthritis
作者: Tang, Sumei1; Huang, Heqing1,2; Hu, Fanlei1; Zhou, Wei3; Guo, Jianping1; Jiang, Huirong4; Mu, Rong1; Li, Zhanguo1
刊名: CLINICAL & DEVELOPMENTAL IMMUNOLOGY
发表日期: 2013
DOI: 10.1155/2013/985301
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: ST2 ; RECEPTOR ; CLASSIFICATION ; EXPRESSION ; CYTOKINE ; CRITERIA ; MEMBER
英文摘要:

Objectives. IL-33, a newly found cytokine which is involved in joint inflammation, could be blocked by a decoy receptor-sST2. The expression and correlation of IL-33 and sST2 in rheumatoid arthritis (RA) are of great interest. Methods. Synovial fluid (SF) was obtained from 120 RA and 30 osteoarthritis (OA) patients, and paired sera were collected from 54 of these RA patients. The levels of IL-33 and sST2 were measured by ELISA. Results. SF IL-33 was significantly higher in RA than in OA, which was correlated with disease activity score 28, erythrocyte sedimentation rate, rheumatoid factor (RF)-IgM, RF-IgG, glucose phosphate isomerase (GPI), and immunoglobulin. Serum IL-33 was correlated positively with SF IL-33 in RA. Furthermore, it was correlated with RF-IgM and GPI. sST2 was partly detectable in RA (13 out of 54, 24.1%), while not in OA. Serum sST2 in RA had no significant correlation with serum IL-33 or SF IL-33. However, SFs from both RA and OA patients did not express sST2. Conclusions. This study supported that IL-33 played an important role in the local pathogenesis of RA. Considering the tight correlation between IL-33 and clinical features, it may become a new target of local treatment.

语种: 英语
所属项目编号: 2010CB529104 ; 31170840 ; 81072401
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China
WOS记录号: WOS:000324713800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58463
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Xiamen Univ, Dept Rheumatol & Immunol, Affiliated Hosp 1, Xiamen 361003, Peoples R China
3.Peking Univ, Hosp 1, Dept Rheumatol & Immunol, Beijing 100034, Peoples R China
4.Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G40RE, Lanark, Scotland

Recommended Citation:
Tang, Sumei,Huang, Heqing,Hu, Fanlei,et al. Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid Arthritis[J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY,2013.
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