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The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope
Zhang Qingyou; Du Junbao; Tang Chaoshu
刊名JOURNAL OF PEDIATRICS
2006-12-01
DOI10.1016/j.jpeds.2006.07.031
149期:6页:777-780
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics
研究领域[WOS]Pediatrics
关键词[WOS]NEURALLY-MEDIATED SYNCOPE ; NEUROCARDIOGENIC SYNCOPE ; DOUBLE-BLIND ; ORTHOSTATIC INTOLERANCE ; RECURRENT SYNCOPE ; PLACEBO
英文摘要

Objective: To determine whether midodrine hydrochloride therapy call prevent vasovagal syncope (VVS) in pediatric patients.

Study design: Children with recurrent syncope (n = 26) were randomly assigned into 2 groups. Group I comprised children given midodrine hydrochloride as first-line therapy in addition to conventional therapy, and group II comprised patients receiving conventional therapy only. Repeat head-up tilt (HUT) testing and follow-up of least 6 months were conducted to evaluate the therapeutic effectiveness and side effects of midodrine in treating VVS in children.

Results: The HUT-based effective rate was significantly higher in group I than in group II (75% vs 20%; P < .05). During the follow-up period, the recurrence of syncope was significantly lower in group I than in group II (P < .05).

Conclusions: Midodrine hydrochlorate is effective in treating VVS in children, especially in preventing recurrent episodes. Few side effects were observed in the present study.

语种英语
WOS记录号WOS:000243242500011
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58470
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
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Zhang Qingyou,Du Junbao,Tang Chaoshu. The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope[J]. JOURNAL OF PEDIATRICS,2006,149(6):777-780.
APA Zhang Qingyou,Du Junbao,&Tang Chaoshu.(2006).The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope.JOURNAL OF PEDIATRICS,149(6),777-780.
MLA Zhang Qingyou,et al."The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope".JOURNAL OF PEDIATRICS 149.6(2006):777-780.
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