|The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope|
|Zhang Qingyou; Du Junbao; Tang Chaoshu|
|刊名||JOURNAL OF PEDIATRICS|
|WOS标题词||Science & Technology|
|关键词[WOS]||NEURALLY-MEDIATED SYNCOPE ; NEUROCARDIOGENIC SYNCOPE ; DOUBLE-BLIND ; ORTHOSTATIC INTOLERANCE ; RECURRENT SYNCOPE ; PLACEBO|
Objective: To determine whether midodrine hydrochloride therapy call prevent vasovagal syncope (VVS) in pediatric patients.
Study design: Children with recurrent syncope (n = 26) were randomly assigned into 2 groups. Group I comprised children given midodrine hydrochloride as first-line therapy in addition to conventional therapy, and group II comprised patients receiving conventional therapy only. Repeat head-up tilt (HUT) testing and follow-up of least 6 months were conducted to evaluate the therapeutic effectiveness and side effects of midodrine in treating VVS in children.
Results: The HUT-based effective rate was significantly higher in group I than in group II (75% vs 20%; P < .05). During the follow-up period, the recurrence of syncope was significantly lower in group I than in group II (P < .05).
Conclusions: Midodrine hydrochlorate is effective in treating VVS in children, especially in preventing recurrent episodes. Few side effects were observed in the present study.
|作者单位||1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China|
2.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
|Zhang Qingyou,Du Junbao,Tang Chaoshu. The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope[J]. JOURNAL OF PEDIATRICS,2006,149(6):777-780.|
|APA||Zhang Qingyou,Du Junbao,&Tang Chaoshu.(2006).The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope.JOURNAL OF PEDIATRICS,149(6),777-780.|
|MLA||Zhang Qingyou,et al."The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope".JOURNAL OF PEDIATRICS 149.6(2006):777-780.|