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学科主题: 精神卫生
题名:
Different white matter abnormalities between the first-episode, treatment-naive patients with posttraumatic stress disorder and generalized anxiety disorder without comorbid conditions
作者: Zhang, Li1; Zhang, Yan1; Li, Lingjiang1,2; Li, Zexuan1; Li, Weihui1; Ma, Ning1,3; Hou, Cailan1,4; Zhang, Zhijun5,6; Zhang, Zhiqiang7; Wang, Lifeng1; Duan, Lian1,8; Lu, Guangming7
关键词: Posttraumatic stress disorder ; Generalized anxiety disorder ; White matter
刊名: JOURNAL OF AFFECTIVE DISORDERS
发表日期: 2011-09-01
DOI: 10.1016/j.jad.2011.03.040
卷: 133, 期:1-2, 页:294-299
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: ANTERIOR CINGULATE ; DIFFUSION TENSOR ; FUNCTIONAL CONNECTIVITY ; SYMPTOM PROVOCATION ; CEREBRAL PERFUSION ; PREFRONTAL CORTEX ; YOUNG-ADULTS ; TRAUMA ; FMRI ; PTSD
英文摘要:

Background: This study compared brain white matter integrity in two groups of patients with DSM-IV anxiety disorders.

Method: Seventeen patients with posttraumatic stress disorder (PTSD), 20 with generalized anxiety disorder (GAD), and 28 healthy controls were assessed on diffusion tensor imaging.

Results: As compared to healthy controls, increased fractional anisotropy (FA) in left superior frontal gyrus in PTSD patients, and increased FA in right postcentral gyrus in GAD subjects were exhibited. Furthermore, patients with PTSD showed reduced FA in right anterior cingulate gyrus relative to GAD subjects. However, there was no significant correlation between the FA value of any altered region and the severity of FTSD or GAD.

Limitations: The sample studied can be considered small. Gender and educational level were not well-matched among the groups.

Conclusions: We tentatively speculate that abnormal white matter integrity of right anterior cingulate gyrus is an important neuroimaging marker of PTSD that distinguishes it from other anxiety disorders such as GAD. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30830046 ; 2007BAI17B02 ; 2009CB918303 ; 2007CB512308 ; 20090162110011
项目资助者: National Natural Science Foundation of China ; National Science and Technology Program of China ; National 973 Program of China ; Chinese Ministry of Education
WOS记录号: WOS:000294934700036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58474
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Guangzhou Brain Hosp, Guangzhou, Guangdong, Peoples R China
2.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
3.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Inst Mental Hlth, Dept Publ Mental Hlth, Beijing 100871, Peoples R China
5.Guangdong Gen Hosp, Guangdong Mental Hlth Inst, Guangzhou, Guangdong, Peoples R China
6.Southeast Univ, Affiliated Zhongda Hosp, Dept Neurol, Nanjing, Peoples R China
7.Southeast Univ, Inst Neuropsychiat, Nanjing, Peoples R China
8.Nanjing Univ Med, Jingling Hosp, Dept Med Imaging, Nanjing, Peoples R China

Recommended Citation:
Zhang, Li,Zhang, Yan,Li, Lingjiang,et al. Different white matter abnormalities between the first-episode, treatment-naive patients with posttraumatic stress disorder and generalized anxiety disorder without comorbid conditions[J]. JOURNAL OF AFFECTIVE DISORDERS,2011,133(1-2):294-299.
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