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学科主题: 基础医学
题名:
Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats
作者: Liang, XB; Luo, Y; Liu, XY; Lu, J; Li, FQ; Wang, Q; Wang, XM; Han, JS
关键词: electro-acupuncture ; glial cell-line-derived neurotrophic factor ; Parkinson&prime ; s disease ; rat ; regeneration
刊名: NEUROREPORT
发表日期: 2003-06-11
DOI: 10.1097/01.wnr.0000074772.23712.94
卷: 14, 期:8, 页:1177-1181
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NEUROTROPHIC FACTOR GDNF ; MEDIAL FOREBRAIN-BUNDLE ; IN-SITU HYBRIDIZATION ; BASAL GANGLIA ; DOPAMINERGIC INNERVATION ; PARKINSONS-DISEASE/ ; SUBSTANTIA-NIGRA ; EXPRESSION ; BRAIN ; DEGENERATION
英文摘要:

Low and high frequency electro-acupuncture (EA) stimulation was used in rats that had been lesioned by medial forebrain bundle transection. Behavioral tests showed that both low and high frequency EA stimulation significantly reduced the amphetamine-induced rotation 2 weeks after the lesion but only high frequency EA improved the rotational behavior at 4 weeks. Analysis of the dopamine content in the striatum did not show any significant change after EA. In situ hybridization showed that high frequency EA stimulation up-regulated the glial cell line-derived neurotrophic factor (GDNF) mRNA in both sides of the globus pallidus, while low frequency EA only affected the unlesioned side. It suggests that the retrograde nourishment of GDNF to the dopaminergic neurons and the balanced activity of different nuclei in the basal ganglia circuit after EA may contribute to the behavioral improvement in these rats, which might be the factors that underlie the effectiveness of EA in the treatment of Parkinson′s disease.

语种: 英语
WOS记录号: WOS:000184486300015
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58477
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Liang, XB,Luo, Y,Liu, XY,et al. Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats[J]. NEUROREPORT,2003,14(8):1177-1181.
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