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学科主题基础医学
Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats
Liang, XB; Luo, Y; Liu, XY; Lu, J; Li, FQ; Wang, Q; Wang, XM; Han, JS
关键词electro-acupuncture glial cell-line-derived neurotrophic factor Parkinson&prime s disease rat regeneration
刊名NEUROREPORT
2003-06-11
DOI10.1097/01.wnr.0000074772.23712.94
14期:8页:1177-1181
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NEUROTROPHIC FACTOR GDNF ; MEDIAL FOREBRAIN-BUNDLE ; IN-SITU HYBRIDIZATION ; BASAL GANGLIA ; DOPAMINERGIC INNERVATION ; PARKINSONS-DISEASE/ ; SUBSTANTIA-NIGRA ; EXPRESSION ; BRAIN ; DEGENERATION
英文摘要

Low and high frequency electro-acupuncture (EA) stimulation was used in rats that had been lesioned by medial forebrain bundle transection. Behavioral tests showed that both low and high frequency EA stimulation significantly reduced the amphetamine-induced rotation 2 weeks after the lesion but only high frequency EA improved the rotational behavior at 4 weeks. Analysis of the dopamine content in the striatum did not show any significant change after EA. In situ hybridization showed that high frequency EA stimulation up-regulated the glial cell line-derived neurotrophic factor (GDNF) mRNA in both sides of the globus pallidus, while low frequency EA only affected the unlesioned side. It suggests that the retrograde nourishment of GDNF to the dopaminergic neurons and the balanced activity of different nuclei in the basal ganglia circuit after EA may contribute to the behavioral improvement in these rats, which might be the factors that underlie the effectiveness of EA in the treatment of Parkinson′s disease.

语种英语
WOS记录号WOS:000184486300015
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被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58477
专题北京大学基础医学院_神经生物学系
作者单位Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
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GB/T 7714
Liang, XB,Luo, Y,Liu, XY,et al. Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats[J]. NEUROREPORT,2003,14(8):1177-1181.
APA Liang, XB.,Luo, Y.,Liu, XY.,Lu, J.,Li, FQ.,...&Han, JS.(2003).Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats.NEUROREPORT,14(8),1177-1181.
MLA Liang, XB,et al."Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats".NEUROREPORT 14.8(2003):1177-1181.
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