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Multi-walled carbon nanotubes induce apoptosis via mitochondrial pathway and scavenger receptor
Wang, Xiang1; Guo, Jian1; Chen, Tian1; Nie, Haiyu2; Wang, Haifang3; Zang, Jiajie1; Cui, Xiaoxing1; Jia, Guang1
关键词Multi-walled carbon nanotubes (MWCNTs) RAW 264.7 cells Apoptosis Scavenger receptors Mitochondria
刊名TOXICOLOGY IN VITRO
2012-09-01
DOI10.1016/j.tiv.2012.05.010
26期:6页:799-806
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]HUMAN ALVEOLAR MACROPHAGES ; SILICA-INDUCED APOPTOSIS ; ENVIRONMENTAL PARTICLES ; COLORIMETRIC ASSAY ; CYTOCHROME-C ; CYTOTOXICITY ; CELLS ; ACTIVATION ; STRESS ; TOXICITY
英文摘要

We have demonstrated previously that the acid-treated multi-walled carbon nanotubes (aci-MWCNTs) and taurine functionalized MWCNTs (tau-MWCNTs) induced differential pulmonary toxicity in mice after instillation exposure. In order to compare differences of cytotoxicity between the aci- and tau-MWCNTs, RAW 264.7 cells (a murine macrophage cell line) were chosen to be exposed to the aci- and tau-MWCNTs at concentrations of 0, 5, 20, 40, and 80 mu g/ml for 12 or 24 h respectively. The results showed that although the aci- and tau-MWCNTs induced only mild decrease in cell viability to RAW 264.7 cells, the two types of MWCNTs elicited significant increase in apoptosis and decreased ability in cellular phagocytosis. Moreover, by using the specific inhibitors, we found that the scavenger receptors (SR) and caspase-9 were actively involved in the apoptosis induced by the aci- and tau-MWCNTs. The taurine functionalized MWCNTs (tau-MWCNTs) showed less cytotoxicity and apoptotic effect to RAW 264.7 cells than those of aci-MWCNTs. Taken together, the results indicated the important role of scavenger receptors and mitochondria in the apoptosis induced by MWCNTs. (C) 2012 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000307323900005
项目编号2011CB933402
资助机构Ministry of Science and Technology of China (973)
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58480
专题北京大学公共卫生学院
作者单位1.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China
2.Peking Univ, Dept Occupat & Environm Hlth, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
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GB/T 7714
Wang, Xiang,Guo, Jian,Chen, Tian,et al. Multi-walled carbon nanotubes induce apoptosis via mitochondrial pathway and scavenger receptor[J]. TOXICOLOGY IN VITRO,2012,26(6):799-806.
APA Wang, Xiang.,Guo, Jian.,Chen, Tian.,Nie, Haiyu.,Wang, Haifang.,...&Jia, Guang.(2012).Multi-walled carbon nanotubes induce apoptosis via mitochondrial pathway and scavenger receptor.TOXICOLOGY IN VITRO,26(6),799-806.
MLA Wang, Xiang,et al."Multi-walled carbon nanotubes induce apoptosis via mitochondrial pathway and scavenger receptor".TOXICOLOGY IN VITRO 26.6(2012):799-806.
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