北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Multi-walled carbon nanotubes induce apoptosis via mitochondrial pathway and scavenger receptor
作者: Wang, Xiang1; Guo, Jian1; Chen, Tian1; Nie, Haiyu2; Wang, Haifang3; Zang, Jiajie1; Cui, Xiaoxing1; Jia, Guang1
关键词: Multi-walled carbon nanotubes (MWCNTs) ; RAW 264.7 cells ; Apoptosis ; Scavenger receptors ; Mitochondria
刊名: TOXICOLOGY IN VITRO
发表日期: 2012-09-01
DOI: 10.1016/j.tiv.2012.05.010
卷: 26, 期:6, 页:799-806
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: HUMAN ALVEOLAR MACROPHAGES ; SILICA-INDUCED APOPTOSIS ; ENVIRONMENTAL PARTICLES ; COLORIMETRIC ASSAY ; CYTOCHROME-C ; CYTOTOXICITY ; CELLS ; ACTIVATION ; STRESS ; TOXICITY
英文摘要:

We have demonstrated previously that the acid-treated multi-walled carbon nanotubes (aci-MWCNTs) and taurine functionalized MWCNTs (tau-MWCNTs) induced differential pulmonary toxicity in mice after instillation exposure. In order to compare differences of cytotoxicity between the aci- and tau-MWCNTs, RAW 264.7 cells (a murine macrophage cell line) were chosen to be exposed to the aci- and tau-MWCNTs at concentrations of 0, 5, 20, 40, and 80 mu g/ml for 12 or 24 h respectively. The results showed that although the aci- and tau-MWCNTs induced only mild decrease in cell viability to RAW 264.7 cells, the two types of MWCNTs elicited significant increase in apoptosis and decreased ability in cellular phagocytosis. Moreover, by using the specific inhibitors, we found that the scavenger receptors (SR) and caspase-9 were actively involved in the apoptosis induced by the aci- and tau-MWCNTs. The taurine functionalized MWCNTs (tau-MWCNTs) showed less cytotoxicity and apoptotic effect to RAW 264.7 cells than those of aci-MWCNTs. Taken together, the results indicated the important role of scavenger receptors and mitochondria in the apoptosis induced by MWCNTs. (C) 2012 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2011CB933402
项目资助者: Ministry of Science and Technology of China (973)
WOS记录号: WOS:000307323900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58480
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China
2.Peking Univ, Dept Occupat & Environm Hlth, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China

Recommended Citation:
Wang, Xiang,Guo, Jian,Chen, Tian,et al. Multi-walled carbon nanotubes induce apoptosis via mitochondrial pathway and scavenger receptor[J]. TOXICOLOGY IN VITRO,2012,26(6):799-806.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Xiang]'s Articles
[Guo, Jian]'s Articles
[Chen, Tian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Xiang]‘s Articles
[Guo, Jian]‘s Articles
[Chen, Tian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace