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学科主题: 临床医学
题名:
The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer
作者: Guo, Li-Hua1; Li, Hui2; Wang, Fang3,4; Yu, Jia3,4; He, Jin-Sheng1
关键词: gastric cancer ; miR-433 ; miR-127 ; KRAS ; MAPK4
刊名: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
发表日期: 2013-07-01
DOI: 10.3390/ijms140714171
卷: 14, 期:7, 页:14171-14184
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: KRAS MUTATIONS ; MICRORNAS ; PROGRESSION
英文摘要:

The discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the mechanism, diagnosis and treatment of human cancers. Currently, the methylation epigenetic silencing of miRNAs with tumor suppressor features by CpG island hypermethylation is emerging as a common hallmark of different tumors. Here we showed that miR-433 and miR-127 were significantly down-regulated in gastric cancer (GC) tissues compared with the adjacent normal regions in 86 paired samples. Moreover, the lower level of miR-433 and miR-127 was associated with pM or pTNM stage in clinical gastric cancer patients. The restored expression of miR-433 and miR-127 in GC cells upon 5-Aza-CdR and TSA treatment suggested the loss of miR-433 and miR-127 was at least partly regulated by epigenetic modification in GC. Furthermore, the ectopic expression of miR-433 and miR-127 in gastric cancer cell lines HGC-27 inhibits cell proliferation, cell cycle progression, cell migration and invasion by directly interacting with the mRNA encoding oncogenic factors KRAS and MAPK4 respectively. Taken together, our results showed that miR-433 and miR-127 might act as tumor suppressors in GC, and it may provide novel diagnostic and therapeutic options for human GC clinical operation in the near future.

语种: 英语
所属项目编号: 2012JBM031
项目资助者: Fundamental Research Funds for the Central Universities
WOS记录号: WOS:000322171700073
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58481
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing Jiaotong Univ, Coll Life Sci & Bioengn, Sch Comp & Informat Technol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Crit Care Med CCM, Beijing 100044, Peoples R China
3.Peking Union Med Coll, Inst Basic Med Sci, Beijing 100005, Peoples R China
4.Chinese Acad Med Sci, Beijing 100005, Peoples R China

Recommended Citation:
Guo, Li-Hua,Li, Hui,Wang, Fang,et al. The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2013,14(7):14171-14184.
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