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学科主题临床医学
The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer
Guo, Li-Hua1; Li, Hui2; Wang, Fang3,4; Yu, Jia3,4; He, Jin-Sheng1
关键词gastric cancer miR-433 miR-127 KRAS MAPK4
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2013-07-01
DOI10.3390/ijms140714171
14期:7页:14171-14184
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]KRAS MUTATIONS ; MICRORNAS ; PROGRESSION
英文摘要

The discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the mechanism, diagnosis and treatment of human cancers. Currently, the methylation epigenetic silencing of miRNAs with tumor suppressor features by CpG island hypermethylation is emerging as a common hallmark of different tumors. Here we showed that miR-433 and miR-127 were significantly down-regulated in gastric cancer (GC) tissues compared with the adjacent normal regions in 86 paired samples. Moreover, the lower level of miR-433 and miR-127 was associated with pM or pTNM stage in clinical gastric cancer patients. The restored expression of miR-433 and miR-127 in GC cells upon 5-Aza-CdR and TSA treatment suggested the loss of miR-433 and miR-127 was at least partly regulated by epigenetic modification in GC. Furthermore, the ectopic expression of miR-433 and miR-127 in gastric cancer cell lines HGC-27 inhibits cell proliferation, cell cycle progression, cell migration and invasion by directly interacting with the mRNA encoding oncogenic factors KRAS and MAPK4 respectively. Taken together, our results showed that miR-433 and miR-127 might act as tumor suppressors in GC, and it may provide novel diagnostic and therapeutic options for human GC clinical operation in the near future.

语种英语
WOS记录号WOS:000322171700073
项目编号2012JBM031
资助机构Fundamental Research Funds for the Central Universities
引用统计
被引频次:60[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58481
专题北京大学第二临床医学院
作者单位1.Beijing Jiaotong Univ, Coll Life Sci & Bioengn, Sch Comp & Informat Technol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Crit Care Med CCM, Beijing 100044, Peoples R China
3.Peking Union Med Coll, Inst Basic Med Sci, Beijing 100005, Peoples R China
4.Chinese Acad Med Sci, Beijing 100005, Peoples R China
推荐引用方式
GB/T 7714
Guo, Li-Hua,Li, Hui,Wang, Fang,et al. The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2013,14(7):14171-14184.
APA Guo, Li-Hua,Li, Hui,Wang, Fang,Yu, Jia,&He, Jin-Sheng.(2013).The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,14(7),14171-14184.
MLA Guo, Li-Hua,et al."The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14.7(2013):14171-14184.
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