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学科主题: 临床医学
题名:
A large-scale study on relationship between cerebral blood flow velocity and blood pressure in a natural population
作者: Zhang, P.; Huang, Y.; Li, Y.; Lu, M.; Wu, Y.
关键词: ultrasonography ; trans-cranial Doppler ; cerebral arteries ; blood flow velocity ; internal carotid artery ; middle cerebral artery
刊名: JOURNAL OF HUMAN HYPERTENSION
发表日期: 2006-10-01
DOI: 10.1038/sj.jhh.1002068
卷: 20, 期:10, 页:742-748
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: TRANSCRANIAL DOPPLER ; HYPERTENSIVE PATIENTS ; HEMODYNAMICS ; ARTERIES ; AUTOREGULATION ; STENOSIS ; FAILURE ; VALUES ; STROKE ; INDEX
英文摘要:

In order to verify the relationship between blood pressure and cerebral blood flow velocity in sub-clinical natural population, 1294 middle-aged and old Beijing rural residents were investigated in autumn 2002. For all subjects, systolic blood flow velocities (V-s) in common carotid artery (CCA), internal carotid artery (ICA) and middle cerebral artery (MCA) were detected with transcranial Doppler. Key factors such as anthropometry, medication use, blood pressure and blood biochemical analysis were investigated at the same time. After controlling for age, gender, diabetes, hypercholesterolaemia, smoking and body mass index, multivariate analysis showed that systolic blood pressure (SBP) correlated positively with V-s at MCA and slight negatively correlated with at CCA. As blood pressure rose by 10 mm Hg, the V-s at MCA increased by 1.63 cm/s. Duration of hypertension (HD) negatively correlated with V-s at MCA (P<0.01). The V-s at MCA in early-stage and chronic hypertensive patients were 92.9 +/- 1.9 and 84.1 +/- 2.3 cm/s, respectively. Antihypertensive treatment could modify the Vs at MCA towards a normal level by lowering blood pressure. In conclusion, the effect of hypertension on cerebral blood flow is complex. Vs at MCA positively correlated with SBP, but negatively related to HD. Antihypertensive treatment might be helpful to keep cerebral blood flow at a normal level.

语种: 英语
WOS记录号: WOS:000241158300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58482
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Cardiovasc Inst, Dept Epidemiol, Beijing 100037, Peoples R China
2.Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
3.Peking Univ, Hosp 1, Dept Neurol, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, P.,Huang, Y.,Li, Y.,et al. A large-scale study on relationship between cerebral blood flow velocity and blood pressure in a natural population[J]. JOURNAL OF HUMAN HYPERTENSION,2006,20(10):742-748.
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