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学科主题基础医学
Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma
Yuan, Xiang1; He, Jiangtu5; Sun, Fenyong4; Gu, Jiang1,2,3
关键词ESCC TSGA10 miR-577 G1-S phase transition p53/p21 pathway Rb/p16 pathway
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2013
6期:12页:2651-U419
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]PROSTATE-CANCER CELLS ; SERUM DEPRIVATION ; DOWN-REGULATION ; PROMOTES PROLIFERATION ; CYCLE PROGRESSION ; UP-REGULATION ; C-MYC ; PROTEIN ; EXPRESSION ; GENE
英文摘要

Testis specific 10 (TSGA10) was originally identified as a testis-specific protein and tumor-associated antigen in a number of cancer types. In this study, we found that down-regulation of TSGA10 was associated with increased malignancy and clinical features of esophageal squamous cell carcinomas (ESCCs). Moreover, increased expression of TSGA10 inhibited, while its knockdown promoted, tumor formation in vivo in nude mice. At the 3′UTR of the TSGA10 gene we identified two binding sites for microRNA-577 (miR-577). Further investigation demonstrated that expression levels of miR-577 and TSGA10 were negatively correlated to each other in ESCC cell lines and tumor samples. Moreover, manipulation of miR-577 and TSGA10 expression confirmed that miR-577 can regulate TSGA10 and in turn affect cell proliferation in vitro. Additionally, with flow cytometry and manipulation of the mir-577/TSGA10 axis, it was found that mir-577/TSGA10 axis influenced the growth of ESCC through regulating the G1-S phase transition. We also obtained evidence to establish that mir-577/TSGA10 axis activation was always accompanied by inactivation of the p53 pathway or the Rb pathway or both, thus, the latter two pathways are obligatory for progression of ESCCs with mir-577/TSGA10 axis activation. In addition, we found that such an interactive pathway in regulating cancer cell proliferation was restricted to a few cancer types including ESCC, but not uniformly applicable to other cancer types. This newly discovered regulatory mechanism provides a new dimension for ESCC diagnosis and therapy.

语种英语
WOS记录号WOS:000333563000001
项目编号81030033 ; 30971150
资助机构National Natural Science Foundation of China
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58483
专题北京大学基础医学院_病理学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100083, Peoples R China
2.Shantou Univ, Coll Med, Mol Pathol Lab, Shantou 515041, Peoples R China
3.Shantou Univ, Coll Med, Guangdong Prov Key Lab Infect Dis & Mol Immunopat, Shantou 515041, Peoples R China
4.Tongji Univ, Shanghai Peoples Hosp 10, Dept Clin Lab Med, Shanghai 200072, Peoples R China
5.Tongji Univ, Shanghai Peoples Hosp 10, Dept Cent Lab, Shanghai 200072, Peoples R China
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Yuan, Xiang,He, Jiangtu,Sun, Fenyong,et al. Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2013,6(12):2651-U419.
APA Yuan, Xiang,He, Jiangtu,Sun, Fenyong,&Gu, Jiang.(2013).Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,6(12),2651-U419.
MLA Yuan, Xiang,et al."Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 6.12(2013):2651-U419.
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