北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病理学系  > 期刊论文
学科主题: 基础医学
题名:
Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma
作者: Yuan, Xiang1; He, Jiangtu5; Sun, Fenyong4; Gu, Jiang1,2,3
关键词: ESCC ; TSGA10 ; miR-577 ; G1-S phase transition ; p53/p21 pathway ; Rb/p16 pathway
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
发表日期: 2013
卷: 6, 期:12, 页:2651-U419
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: PROSTATE-CANCER CELLS ; SERUM DEPRIVATION ; DOWN-REGULATION ; PROMOTES PROLIFERATION ; CYCLE PROGRESSION ; UP-REGULATION ; C-MYC ; PROTEIN ; EXPRESSION ; GENE
英文摘要:

Testis specific 10 (TSGA10) was originally identified as a testis-specific protein and tumor-associated antigen in a number of cancer types. In this study, we found that down-regulation of TSGA10 was associated with increased malignancy and clinical features of esophageal squamous cell carcinomas (ESCCs). Moreover, increased expression of TSGA10 inhibited, while its knockdown promoted, tumor formation in vivo in nude mice. At the 3′UTR of the TSGA10 gene we identified two binding sites for microRNA-577 (miR-577). Further investigation demonstrated that expression levels of miR-577 and TSGA10 were negatively correlated to each other in ESCC cell lines and tumor samples. Moreover, manipulation of miR-577 and TSGA10 expression confirmed that miR-577 can regulate TSGA10 and in turn affect cell proliferation in vitro. Additionally, with flow cytometry and manipulation of the mir-577/TSGA10 axis, it was found that mir-577/TSGA10 axis influenced the growth of ESCC through regulating the G1-S phase transition. We also obtained evidence to establish that mir-577/TSGA10 axis activation was always accompanied by inactivation of the p53 pathway or the Rb pathway or both, thus, the latter two pathways are obligatory for progression of ESCCs with mir-577/TSGA10 axis activation. In addition, we found that such an interactive pathway in regulating cancer cell proliferation was restricted to a few cancer types including ESCC, but not uniformly applicable to other cancer types. This newly discovered regulatory mechanism provides a new dimension for ESCC diagnosis and therapy.

语种: 英语
所属项目编号: 81030033 ; 30971150
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000333563000001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58483
Appears in Collections:基础医学院_病理学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma.pdf(5370KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100083, Peoples R China
2.Shantou Univ, Coll Med, Mol Pathol Lab, Shantou 515041, Peoples R China
3.Shantou Univ, Coll Med, Guangdong Prov Key Lab Infect Dis & Mol Immunopat, Shantou 515041, Peoples R China
4.Tongji Univ, Shanghai Peoples Hosp 10, Dept Clin Lab Med, Shanghai 200072, Peoples R China
5.Tongji Univ, Shanghai Peoples Hosp 10, Dept Cent Lab, Shanghai 200072, Peoples R China

Recommended Citation:
Yuan, Xiang,He, Jiangtu,Sun, Fenyong,et al. Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2013,6(12):2651-U419.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yuan, Xiang]'s Articles
[He, Jiangtu]'s Articles
[Sun, Fenyong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yuan, Xiang]‘s Articles
[He, Jiangtu]‘s Articles
[Sun, Fenyong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace