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学科主题: 基础医学
题名:
Chronic hepatitis B: treatment alert
作者: Chang, Ting-Tsung; Zhang, Hui; Jia, Jidong; Leung, Nancy Wai-Yee; Guan, Richard; Jafri, S. M. Wasim; Lesmana, Laurentlus A.; Liaw, Yun-Fan; Locarnini, Stephen; Omata, Masao; Sollano, Jose D.; Suh, Dong Jin; Mahachai, Varocha; Phiet, Pham Hoang; Sarin, Shiv K.; Yao, Guangbi; Yoon, Seung Kew; ACT-HBV Asia-Pacific Steering
关键词: ALT levels ; consensus statement ; HBeAg negative ; HBeAg positive ; HBV DNA levels ; treatment guidelines
刊名: LIVER INTERNATIONAL
发表日期: 2006-12-01
DOI: 10.1111/j.1478-3231.2006.01374.x
卷: suppl.2, 期:0, 页:47-58
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: ADEFOVIR DIPIVOXIL ; HEPATOCELLULAR-CARCINOMA ; VIRUS INFECTION ; LAMIVUDINE THERAPY ; UNITED-STATES ; LYMPHOBLASTOID INTERFERON ; PREEMPTIVE LAMIVUDINE ; CONSENSUS STATEMENT ; TREATMENT ALGORITHM ; POSITIVE PATIENTS
英文摘要:

Chronic hepatitis B (CHB) is a serious global health concern, particularly in the Asia-Pacific region. New information on the clinical management of CHB is emerging rapidly, requiring that physicians be alerted to updated treatment recommendations. The ACT-HBV Asia-Pacific Steering Committee members, composed of experts in hepatitis B from throughout the Asia-Pacific region, reviewed and discussed new clinical data as reported in the literature or presented at recent international congresses, and recommended that physicians be alerted to updated treatment recommendations. Hepatitis B e antigen (HBeAg)-positive patients with HBV DNA levels of >= 20 000 IU/ml (>= 10(5) copies/ml) and elevated alanine aminotransferase levels should be considered for treatment. It is suggested that HBV DNA >= 2000 IU/ml (>= 10(4) copies/ml) is the more appropriate threshold for the treatment of HBeAg-negative patients. Lamivudine, adefovir dipivoxil, interferon alpha-2b, thymosin alpha-1, and, most recently, entecavir, and pegylated interferon alpha-2a are licensed for the management of CHB. The treatment recommendations from the 2005 Asian-Pacific Consensus Statement on the Management of Chronic Hepatitis B have been updated to incorporate these new therapeutic options. A summary of treatment recommendations for special patient populations is also included.

语种: 英语
WOS记录号: WOS:000242602200007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58485
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Univ Santo Tomas Hosp, Manila 100864, Philippines
2.Asan Med Ctr, Seoul 138376, South Korea
3.Univ Delhi, GB Pant Hosp, New Delhi 110002, India
4.Univ Tokyo, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan
5.Natl Cheng Kung Univ Hosp, Dept Med, Tainan 70428, Taiwan
6.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
7.Aga Khan Univ, Karachi 3500, Pakistan
8.Univ Indonesia, Jakarta Dept Med, Jakarta 10350, Indonesia
9.Victorian Infect Dis Reference Lab, Melbourne, Vic 3051, Australia
10.Capital Univ Med Sci, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
11.Alice Ho Miu Ling Nethersole Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
12.Natl Univ Singapore Hosp, Mt Elizabeth Med Ctr, Singapore 228510, Singapore
13.Chang Gung Mem Hosp & Univ, Liver Res Unit, Taipei 105, Taiwan
14.Chulalongkorn Univ, GI Unit, Dept Med, Bangkok 10330, Thailand
15.Univ Med & Pharm, Dept Immunol & Physiopathol, Ho Chi Minh City, Vietnam
16.Catholic Univ Korea, Div Hepatogastroenterol, Div Internal Med, Kangnam St Marys Hosp, Seoul 137040, South Korea
17.Shanghai Jing An Qu Cent Hosp, Clin Immun Res Ctr, Shanghai 200040, Peoples R China

Recommended Citation:
Chang, Ting-Tsung,Zhang, Hui,Jia, Jidong,et al. Chronic hepatitis B: treatment alert[J]. LIVER INTERNATIONAL,2006,suppl.2(0):47-58.
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