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Metabolic profiling of GuanXin II prescription based on metabolic fingerprinting and chemical analysis
Qiao, Xue; Han, Jian; Xu, Man; Zhang, Zi-chuan; Ye, Min; Ye, Guan; Guo, De-an
关键词GuanXin II prescription Formulated Chinese medicine LC/MS Metabolic profile
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2011-03-25
DOI10.1016/j.jpba.2010.10.017
54期:4页:789-798
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; IONIZATION-MASS-SPECTROMETRY ; MAJOR BIOACTIVE COMPONENT ; DIODE-ARRAY DETECTOR ; IN-VITRO METABOLISM ; RHIZOMA-CHUANXIONG ; ORAL BIOAVAILABILITY ; SALVIA-MILTIORRHIZA ; HPLC-MS ; ACID-B
英文摘要

A sensitive LC/MS method was established to investigate the in vivo metabolism of GuanXin II prescription, a five-component Chinese herbal medicine formulation. Rat plasma, bile, urine, and feces were collected and analyzed following oral administration of the water decoction. A total of 50 compounds were identified, including 17 prototypes and 33 metabolites underwent methylation, oxidation, hydrolysis, sulfate conjugation, glucuronide conjugation, and glutathion conjugation. In addition, the component herb of the formulation from which the metabolites were derived was also identified. Among the five component herbs, Rhizoma Chuanxiong, Flos Carthami, and Lignum Dalbergiae Odoriferae were actively metabolized, contributing 26 metabolites and 2 prototypes, while Radix Salviae Miltiorrhizae and Radix Paeoniae Rubra underwent less biotransformation. yielding 7 metatbolites and 15 prototypes. This is the first study on the metabolic profile of GuanXin II prescription. The results could be valuable to elucidate the material basis of this formulated Chinese medicine. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000286351200023
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58487
专题北京大学药学院_天然药物学系
北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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Qiao, Xue,Han, Jian,Xu, Man,et al. Metabolic profiling of GuanXin II prescription based on metabolic fingerprinting and chemical analysis[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,54(4):789-798.
APA Qiao, Xue.,Han, Jian.,Xu, Man.,Zhang, Zi-chuan.,Ye, Min.,...&Guo, De-an.(2011).Metabolic profiling of GuanXin II prescription based on metabolic fingerprinting and chemical analysis.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,54(4),789-798.
MLA Qiao, Xue,et al."Metabolic profiling of GuanXin II prescription based on metabolic fingerprinting and chemical analysis".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 54.4(2011):789-798.
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