IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Comparison of contrast enhanced ultrasound and contrast enhanced CT or MRI in monitoring percutaneous thermal ablation procedure in patients with hepatocellular carcinoma: A multi-center study in China
Lu, Ming-De; Yu, Xiao-Ling; Li, An-Hua; Jiang, Tian-An; Chen, Min-Hua; Zhao, Bao-Zhen; Zhou, Xiao-Dong; Wang, Jin-Rui
关键词hepatocellular carcinoma percutaneous thermal ablation contrast-enhanced US
刊名ULTRASOUND IN MEDICINE AND BIOLOGY
2007-11-01
DOI10.1016/j.ultrasmedbio.2007.05.004
33期:11页:1736-1749
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]FOCAL LIVER-LESIONS ; MICROWAVE COAGULATION THERAPY ; RADIO-FREQUENCY ABLATION ; IMAGING FOLLOW-UP ; POWER DOPPLER US ; RADIOFREQUENCY ABLATION ; ETHANOL INJECTION ; TUMOR ABLATION ; HELICAL CT ; HEPATIC-TUMORS
英文摘要

To evaluate the ability of contrast enhanced ultrasound (CEUS) in monitoring percutaneous thermal ablation procedure in patients with hepatocellular carcinoma (HCC) in comparison with contrast enhanced computed tomography (CECT) and/or magnetic resonance imaging (CEMRI). A total of 151 patients were enrolled in the study. Before the radio-frequency (RF) or microwave ablation treatment, tumor vascularity was assessed in 139 patients with three imaging modalities i.e., US (139 exams), CEUS (139 exams) and CECT (103 exams)/CEMR (36 exams). CEUS examination was performed using a sulphur hexafluoride-filled microbubble contrast agent (SonoVue (R), Bracco, Milan, Italy) and real-time contrast-specific imaging techniques. Within 30 +/- 7 d after the ablation procedure, 118/139 patients were monitored to assess the tumor response to treatment. Before ablation, contrast enhancement within tumor was observed in 129/139 (92.8%) patients with CEUS and 133/139 (95.7%) patients with CECT/CEMRI. Compared with CECT/CEMRI, CEUS sensitivity and accuracy in detecting tumor vascularity were 97.0% and 94.2%, respectively. One month after treatment, no enhancement was seen in 110/118 (93.2%) both on CEUS and CECT/CEMRI. Concordance between CEUS and CECT/CEMR on the presence of residual vascularization was obtained in four patients (true positive). The specificity and accuracy of CEUS in detecting tumor vascularity were 98.2% and 96.6%, respectively. The periprocedural impact of SonoVue administration on the assessment of treatment extent was also evaluated in a subgroup of patients and CEUS showed its superiority compared with baseline US in defining treatment outcome. In conclusion, in the detection of HCC tumor vascularity and assessment of response to thermal ablation after 1 month, real time CEUS provided results comparable to those obtained with CECT/CEMRI. CEUS examination proved to be a safe and easy to access procedure, with potential for diagnostic impact in the clinical practice. (E-mail: lumd@21cn.com) (c) 2007 World Federation for Ultrasound in Medicine & Biology.

语种英语
WOS记录号WOS:000250815100007
引用统计
被引频次:63[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58490
专题北京大学临床肿瘤学院
作者单位1.Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
2.PLA, Gen Hosp, Beijing, Peoples R China
3.Sun Yat Sen Univ, Ctr Canc, Guangzhou, Guangdong, Peoples R China
4.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Hangzhou, Peoples R China
5.Peking Univ, Sch Oncol, Beijing, Peoples R China
6.Peking Univ, Hosp 3, Beijing, Peoples R China
7.Second Mil Med Univ, Changhai Hosp, Shanghai, Peoples R China
8.Fourth Mil Med Univ, Xijing Hosp, Xian 710032, Peoples R China
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GB/T 7714
Lu, Ming-De,Yu, Xiao-Ling,Li, An-Hua,et al. Comparison of contrast enhanced ultrasound and contrast enhanced CT or MRI in monitoring percutaneous thermal ablation procedure in patients with hepatocellular carcinoma: A multi-center study in China[J]. ULTRASOUND IN MEDICINE AND BIOLOGY,2007,33(11):1736-1749.
APA Lu, Ming-De.,Yu, Xiao-Ling.,Li, An-Hua.,Jiang, Tian-An.,Chen, Min-Hua.,...&Wang, Jin-Rui.(2007).Comparison of contrast enhanced ultrasound and contrast enhanced CT or MRI in monitoring percutaneous thermal ablation procedure in patients with hepatocellular carcinoma: A multi-center study in China.ULTRASOUND IN MEDICINE AND BIOLOGY,33(11),1736-1749.
MLA Lu, Ming-De,et al."Comparison of contrast enhanced ultrasound and contrast enhanced CT or MRI in monitoring percutaneous thermal ablation procedure in patients with hepatocellular carcinoma: A multi-center study in China".ULTRASOUND IN MEDICINE AND BIOLOGY 33.11(2007):1736-1749.
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