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学科主题: 公共卫生
题名:
Vitamin D and Graves′ Disease: A Meta-Analysis Update
作者: Xu, Mei-Yan1; Cao, Bing2; Yin, Jian1; Wang, Dong-Fang2; Chen, Kai-Li3; Lu, Qing-Bin2
刊名: NUTRIENTS
发表日期: 2015-05-01
DOI: 10.3390/nu7053813
卷: 7, 期:5, 页:3813-3827
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: AUTOIMMUNE THYROID-DISEASES ; D-RECEPTOR GENE ; PARATHYROID-HORMONE ; ASSOCIATION ; POPULATION ; DENSITY
英文摘要:

The association between vitamin D levels and Graves′ disease is not well studied. This update review aims to further analyze the relationship in order to provide an actual view of estimating the risk. We searched for the publications on vitamin D and Graves′ disease in English or Chinese on PubMed, EMBASE, Chinese National Knowledge Infrastructure, China Biology Medical and Wanfang databases. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated for the vitamin D levels. Pooled odds ratio (OR) and 95% CI were calculated for vitamin D deficiency. We also performed sensitivity analysis and meta-regression. Combining effect sizes from 26 studies for Graves′ disease as an outcome found a pooled effect of SMD = -0.77 (95% CI: -1.12, -0.42; p < 0.001) favoring the low vitamin D level by the random effect analysis. The meta-regression found assay method had the definite influence on heterogeneity (p = 0.048). The patients with Graves′ disease were more likely to be deficient in vitamin D compared to the controls (OR = 2.24, 95% CI: 1.31, 3.81) with a high heterogeneity (I-2 = 84.1%, p < 0.001). We further confirmed that low vitamin D status may increase the risk of Graves′ disease.

语种: 英语
所属项目编号: 2014QN09 ; YN201411
项目资助者: Aerospace Center Hospital ; School of Public Health, Peking University
WOS记录号: WOS:000356240500043
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58492
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Aerosp Ctr Hosp, Dept Nutr, Beijing 100049, Peoples R China
2.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Aerosp Ctr Hosp, Dept Resp, Beijing 100049, Peoples R China

Recommended Citation:
Xu, Mei-Yan,Cao, Bing,Yin, Jian,et al. Vitamin D and Graves&prime; Disease: A Meta-Analysis Update[J]. NUTRIENTS,2015,7(5):3813-3827.
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