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Vitamin D and Graves′ Disease: A Meta-Analysis Update
Xu, Mei-Yan1; Cao, Bing2; Yin, Jian1; Wang, Dong-Fang2; Chen, Kai-Li3; Lu, Qing-Bin2
刊名NUTRIENTS
2015-05-01
DOI10.3390/nu7053813
7期:5页:3813-3827
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]AUTOIMMUNE THYROID-DISEASES ; D-RECEPTOR GENE ; PARATHYROID-HORMONE ; ASSOCIATION ; POPULATION ; DENSITY
英文摘要

The association between vitamin D levels and Graves′ disease is not well studied. This update review aims to further analyze the relationship in order to provide an actual view of estimating the risk. We searched for the publications on vitamin D and Graves′ disease in English or Chinese on PubMed, EMBASE, Chinese National Knowledge Infrastructure, China Biology Medical and Wanfang databases. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated for the vitamin D levels. Pooled odds ratio (OR) and 95% CI were calculated for vitamin D deficiency. We also performed sensitivity analysis and meta-regression. Combining effect sizes from 26 studies for Graves′ disease as an outcome found a pooled effect of SMD = -0.77 (95% CI: -1.12, -0.42; p < 0.001) favoring the low vitamin D level by the random effect analysis. The meta-regression found assay method had the definite influence on heterogeneity (p = 0.048). The patients with Graves′ disease were more likely to be deficient in vitamin D compared to the controls (OR = 2.24, 95% CI: 1.31, 3.81) with a high heterogeneity (I-2 = 84.1%, p < 0.001). We further confirmed that low vitamin D status may increase the risk of Graves′ disease.

语种英语
WOS记录号WOS:000356240500043
项目编号2014QN09 ; YN201411
资助机构Aerospace Center Hospital ; School of Public Health, Peking University
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58492
专题北京大学公共卫生学院
北京大学公共卫生学院_公共卫生学院
作者单位1.Aerosp Ctr Hosp, Dept Nutr, Beijing 100049, Peoples R China
2.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Aerosp Ctr Hosp, Dept Resp, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Xu, Mei-Yan,Cao, Bing,Yin, Jian,et al. Vitamin D and Graves&prime; Disease: A Meta-Analysis Update[J]. NUTRIENTS,2015,7(5):3813-3827.
APA Xu, Mei-Yan,Cao, Bing,Yin, Jian,Wang, Dong-Fang,Chen, Kai-Li,&Lu, Qing-Bin.(2015).Vitamin D and Graves′ Disease: A Meta-Analysis Update.NUTRIENTS,7(5),3813-3827.
MLA Xu, Mei-Yan,et al."Vitamin D and Graves′ Disease: A Meta-Analysis Update".NUTRIENTS 7.5(2015):3813-3827.
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