|Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy|
|Li, Xiao-Ting; Tang, Lei; Chen, Ying; Li, Yan-Ling; Zhang, Xiao-Peng; Sun, Ying-Shi|
|关键词||Gastric cancer Computed tomography Fat Survival|
|刊名||JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY|
|WOS标题词||Science & Technology|
|关键词[WOS]||BODY-MASS INDEX ; COMPUTED-TOMOGRAPHY ; PANCREATIC-CANCER ; RISK-FACTOR ; OBESITY ; IMPACT ; SIZE ; AREA ; PANCREATICODUODENECTOMY ; METAANALYSIS|
Abdominal adipose distribution may be associated with tumor growth, but its impact on gastric carcinoma survival after neo-adjuvant therapies is uncertain. This retrospective study was to determine the association linking BMI and CT-measured fat parameters to the survival in advanced gastric cancer patients who underwent preoperative chemotherapy.
Eighty-four consecutive patients with locally advanced gastric cancer who received neo-adjuvant chemotherapy and following gastrectomy were identified between January 2005 and June 2008. CT parameters were measured retrospectively on the CT images obtained before chemotherapy initiation. Subcutaneous fat thicknesses of the anterior, lateral, and posterior abdominal wall (ASFT, LSFT, and PSFT) represented subcutaneous fat. Intraperitoneal fat thickness (IFT) and retro-renal fat thickness represented visceral fat. Association linking BMI and CT factors to overall survival was evaluated with survival analysis.
ASFT and PSFT above the median value (i.e., high ASFT and PSFT) were associated with longer OS (P = 0.001; 0.003). Conversely, high IFT and high IFT/PSFT were associated with shorter OS (P = 0.003; 0.003) and DFS (P < 0.001; 0.004). By multivariate analysis, high IFT and PSFT were independently associated with OS (HR 2.94, 95 % CI 1.54-5.60; 0.38, 95 % CI 0.21-0.71) and DFS (HR 3.28, 95 % CI 1.55-6.93; 0.42, 95 % CI 0.21-0.82). BMI was not significant for OS and DFS.
This study provided the first evidence that IFT, ASFT, and PSFT measured before neo-adjuvant chemotherapy were likely to be useful predictive biomarkers for survival of advanced gastric cancer patients.
|项目编号||2011CB707705 ; 81471640 ; 81371715 ; 2011-2015-02 ; 2013-3-083 ; Z121107001012115|
|资助机构||National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Capital Health Research and Development of Special Foundation ; Beijing Health System High Level Health Technical Personnel Training Plan ; Capital Special Project for Featured Clinical Application|
|作者单位||Peking Univ, Dept Radiol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China|
|Li, Xiao-Ting,Tang, Lei,Chen, Ying,et al. Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2015,141(7):1237-1247.|
|APA||Li, Xiao-Ting,Tang, Lei,Chen, Ying,Li, Yan-Ling,Zhang, Xiao-Peng,&Sun, Ying-Shi.(2015).Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,141(7),1237-1247.|
|MLA||Li, Xiao-Ting,et al."Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 141.7(2015):1237-1247.|