IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy
Li, Xiao-Ting; Tang, Lei; Chen, Ying; Li, Yan-Ling; Zhang, Xiao-Peng; Sun, Ying-Shi
关键词Gastric cancer Computed tomography Fat Survival
刊名JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
2015-07-01
DOI10.1007/s00432-014-1893-y
141期:7页:1237-1247
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]BODY-MASS INDEX ; COMPUTED-TOMOGRAPHY ; PANCREATIC-CANCER ; RISK-FACTOR ; OBESITY ; IMPACT ; SIZE ; AREA ; PANCREATICODUODENECTOMY ; METAANALYSIS
英文摘要

Abdominal adipose distribution may be associated with tumor growth, but its impact on gastric carcinoma survival after neo-adjuvant therapies is uncertain. This retrospective study was to determine the association linking BMI and CT-measured fat parameters to the survival in advanced gastric cancer patients who underwent preoperative chemotherapy.

Eighty-four consecutive patients with locally advanced gastric cancer who received neo-adjuvant chemotherapy and following gastrectomy were identified between January 2005 and June 2008. CT parameters were measured retrospectively on the CT images obtained before chemotherapy initiation. Subcutaneous fat thicknesses of the anterior, lateral, and posterior abdominal wall (ASFT, LSFT, and PSFT) represented subcutaneous fat. Intraperitoneal fat thickness (IFT) and retro-renal fat thickness represented visceral fat. Association linking BMI and CT factors to overall survival was evaluated with survival analysis.

ASFT and PSFT above the median value (i.e., high ASFT and PSFT) were associated with longer OS (P = 0.001; 0.003). Conversely, high IFT and high IFT/PSFT were associated with shorter OS (P = 0.003; 0.003) and DFS (P < 0.001; 0.004). By multivariate analysis, high IFT and PSFT were independently associated with OS (HR 2.94, 95 % CI 1.54-5.60; 0.38, 95 % CI 0.21-0.71) and DFS (HR 3.28, 95 % CI 1.55-6.93; 0.42, 95 % CI 0.21-0.82). BMI was not significant for OS and DFS.

This study provided the first evidence that IFT, ASFT, and PSFT measured before neo-adjuvant chemotherapy were likely to be useful predictive biomarkers for survival of advanced gastric cancer patients.

语种英语
WOS记录号WOS:000354710000010
项目编号2011CB707705 ; 81471640 ; 81371715 ; 2011-2015-02 ; 2013-3-083 ; Z121107001012115
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Capital Health Research and Development of Special Foundation ; Beijing Health System High Level Health Technical Personnel Training Plan ; Capital Special Project for Featured Clinical Application
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58496
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_医学影像科
作者单位Peking Univ, Dept Radiol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Li, Xiao-Ting,Tang, Lei,Chen, Ying,et al. Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2015,141(7):1237-1247.
APA Li, Xiao-Ting,Tang, Lei,Chen, Ying,Li, Yan-Ling,Zhang, Xiao-Peng,&Sun, Ying-Shi.(2015).Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,141(7),1237-1247.
MLA Li, Xiao-Ting,et al."Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 141.7(2015):1237-1247.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Xiao-Ting]的文章
[Tang, Lei]的文章
[Chen, Ying]的文章
百度学术
百度学术中相似的文章
[Li, Xiao-Ting]的文章
[Tang, Lei]的文章
[Chen, Ying]的文章
必应学术
必应学术中相似的文章
[Li, Xiao-Ting]的文章
[Tang, Lei]的文章
[Chen, Ying]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。