IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy
Li, Xiao-Ting; Tang, Lei; Chen, Ying; Li, Yan-Ling; Zhang, Xiao-Peng; Sun, Ying-Shi
关键词Gastric cancer Computed tomography Fat Survival
刊名JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
2015-07-01
DOI10.1007/s00432-014-1893-y
141期:7页:1237-1247
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]BODY-MASS INDEX ; COMPUTED-TOMOGRAPHY ; PANCREATIC-CANCER ; RISK-FACTOR ; OBESITY ; IMPACT ; SIZE ; AREA ; PANCREATICODUODENECTOMY ; METAANALYSIS
英文摘要

Abdominal adipose distribution may be associated with tumor growth, but its impact on gastric carcinoma survival after neo-adjuvant therapies is uncertain. This retrospective study was to determine the association linking BMI and CT-measured fat parameters to the survival in advanced gastric cancer patients who underwent preoperative chemotherapy.

Eighty-four consecutive patients with locally advanced gastric cancer who received neo-adjuvant chemotherapy and following gastrectomy were identified between January 2005 and June 2008. CT parameters were measured retrospectively on the CT images obtained before chemotherapy initiation. Subcutaneous fat thicknesses of the anterior, lateral, and posterior abdominal wall (ASFT, LSFT, and PSFT) represented subcutaneous fat. Intraperitoneal fat thickness (IFT) and retro-renal fat thickness represented visceral fat. Association linking BMI and CT factors to overall survival was evaluated with survival analysis.

ASFT and PSFT above the median value (i.e., high ASFT and PSFT) were associated with longer OS (P = 0.001; 0.003). Conversely, high IFT and high IFT/PSFT were associated with shorter OS (P = 0.003; 0.003) and DFS (P < 0.001; 0.004). By multivariate analysis, high IFT and PSFT were independently associated with OS (HR 2.94, 95 % CI 1.54-5.60; 0.38, 95 % CI 0.21-0.71) and DFS (HR 3.28, 95 % CI 1.55-6.93; 0.42, 95 % CI 0.21-0.82). BMI was not significant for OS and DFS.

This study provided the first evidence that IFT, ASFT, and PSFT measured before neo-adjuvant chemotherapy were likely to be useful predictive biomarkers for survival of advanced gastric cancer patients.

语种英语
WOS记录号WOS:000354710000010
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58496
Collection北京大学临床肿瘤学院
北京大学临床肿瘤学院_医学影像科
作者单位Peking Univ, Dept Radiol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China
Recommended Citation
GB/T 7714
Li, Xiao-Ting,Tang, Lei,Chen, Ying,et al. Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2015,141(7):1237-1247.
APA Li, Xiao-Ting,Tang, Lei,Chen, Ying,Li, Yan-Ling,Zhang, Xiao-Peng,&Sun, Ying-Shi.(2015).Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,141(7),1237-1247.
MLA Li, Xiao-Ting,et al."Visceral and subcutaneous fat as new independent predictive factors of survival in locally advanced gastric carcinoma patients treated with neo-adjuvant chemotherapy".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 141.7(2015):1237-1247.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Li, Xiao-Ting]'s Articles
[Tang, Lei]'s Articles
[Chen, Ying]'s Articles
百度学术
百度学术Similar articles in
[Li, Xiao-Ting]'s Articles
[Tang, Lei]'s Articles
[Chen, Ying]'s Articles
必应学术
必应学术Similar articles in
[Li, Xiao-Ting]'s Articles
[Tang, Lei]'s Articles
[Chen, Ying]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.