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学科主题: 临床医学
题名:
Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging
作者: Zhu, Hua1; Zhao, Jun2; Lin, Xinfeng1; Hong, Ye3; Li, Chun2; Yang, Zhi1
关键词: indium-111 ; D-glucosamine ; core-cross-linked polymeric micelles ; glyco-nanoparticles ; tumor imaging agent
刊名: MOLECULES
发表日期: 2013-06-01
DOI: 10.3390/molecules18066425
卷: 18, 期:6, 页:6425-6438
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: POLYMERIC MICELLES ; DRUG-DELIVERY ; D-GLUCOSE ; AGENT ; PROTEINS ; THERAPY ; SPECT ; ACID
英文摘要:

D-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (In-111). The resultant nano-scale tumor-targeting imaging tracer, In-111-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 +/- 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.

语种: 英语
所属项目编号: 81071198 ; 81172082 ; 7132040
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000320770800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58500
Appears in Collections:北京大学临床肿瘤学院_核医学科_期刊论文

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作者单位: 1.China Inst Atom Energy, Beijing 102413, Peoples R China
2.Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Dept Nucl Med, Beijing 100142, Peoples R China
3.Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Unit 59, Houston, TX 77030 USA

Recommended Citation:
Zhu, Hua,Zhao, Jun,Lin, Xinfeng,et al. Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging[J]. MOLECULES,2013,18(6):6425-6438.
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