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学科主题基础医学
Differences in Neural-Immune Gene Expression Response in Rat Spinal Dorsal Horn Correlates with Variations in Electroacupuncture Analgesia
Wang, Ke1,2; Zhang, Rong3,4,5; Xiang, Xiaohui2,3,4,5; He, Fei1,2; Lin, Libo1; Ping, Xingjie3,4,5; Yu, Lei6,7; Han, Jisheng3,4,5; Zhao, Guoping1,2,8,9; Zhang, Qinghua1,2; Cui, Cailian3,4,5
刊名PLOS ONE
2012-08-03
DOI10.1371/journal.pone.0042331
7期:8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]TAIL-FLICK TEST ; NEUROPATHIC PAIN ; INDIVIDUAL-DIFFERENCES ; ACUPUNCTURE ANALGESIA ; APJ RECEPTOR ; MECHANISMS ; CHOLECYSTOKININ ; STIMULATION ; APELIN ; CORD
英文摘要

Background: Electroacupuncture (EA) has been widely used to alleviate diverse pains. Accumulated clinical experiences and experimental observations indicated that significant differences exist in sensitivity to EA analgesia for individuals of patients and model animals. However, the molecular mechanism accounting for this difference remains obscure.

Methodology/Principal Findings: We classified model male rats into high-responder (HR; TFL changes >150) and non-responder (NR; TFL changes <= 0) groups based on changes of their pain threshold detected by tail-flick latency (TFL) before and after 2 Hz or 100 Hz EA treatment. Gene expression analysis of spinal dorsal horn (DH) revealed divergent expression in HR and NR after 2 Hz/100 Hz EA. The expression of the neurotransmitter system related genes was significantly highly regulated in the HR animals while the proinflammation cytokines related genes were up-regulated more significantly in NR than that in HR after 2 Hz and 100 Hz EA stimulation, especially in the case of 2 Hz stimulation.

Conclusions/Significance: Our results suggested that differential regulation and coordination of neural-immune related genes might play an important role for individual variations in analgesic effects responding to EA in DH. It also provided new candidate genes related to EA responsiveness for future investigation.

语种英语
WOS记录号WOS:000307284100069
项目编号973-2007CB512501 ; 20100480643 ; 30801491
资助机构National Basic Research Program of China ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58503
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Natl Engn Res Ctr Biochip Shanghai, Shanghai, Peoples R China
2.Peking Univ, Minist Publ Hlth, Beijing 100871, Peoples R China
3.Dept Genet, Piscataway, NJ USA
4.Chinese Natl Human Genome Ctr Shanghai, Shanghai MOST Key Lab Hlth & Dis Genom, Shanghai, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Neurosci Res Inst, Beijing 100871, Peoples R China
6.Peking Univ, Minist Educ, Key Lab Neurosci, Beijing 100871, Peoples R China
7.Rutgers State Univ, Ctr Alcohol Studies, Piscataway, NJ 08854 USA
8.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Microbiol, Shatin, Hong Kong, Peoples R China
9.Chinese Univ Hong Kong, Prince Wales Hosp, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Wang, Ke,Zhang, Rong,Xiang, Xiaohui,et al. Differences in Neural-Immune Gene Expression Response in Rat Spinal Dorsal Horn Correlates with Variations in Electroacupuncture Analgesia[J]. PLOS ONE,2012,7(8).
APA Wang, Ke.,Zhang, Rong.,Xiang, Xiaohui.,He, Fei.,Lin, Libo.,...&Cui, Cailian.(2012).Differences in Neural-Immune Gene Expression Response in Rat Spinal Dorsal Horn Correlates with Variations in Electroacupuncture Analgesia.PLOS ONE,7(8).
MLA Wang, Ke,et al."Differences in Neural-Immune Gene Expression Response in Rat Spinal Dorsal Horn Correlates with Variations in Electroacupuncture Analgesia".PLOS ONE 7.8(2012).
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