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学科主题: 药学
题名:
Identification of major compounds in rat bile after oral administration of total triterpenoids of Ganoderma lucidum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry
作者: Guo, Xiao-Yu1; Han, Jian1; Ye, Min1; Ma, Xiao-Chi2; Shen, Xuan1; Xue, Bin-Bin1; Che, Qing-Ming1
关键词: Ganoderma lucidum ; Triterpenoids ; Metabolites ; HPLC-DAD-ESI-MSn ; LC-ESI-IT-TOF/MS
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2012-04-07
DOI: 10.1016/j.jpba.2012.01.030
卷: 63, 页:29-39
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: FR KARST ; QUANTITATIVE-DETERMINATION ; ACID-F ; TERPENOIDS ; CONSTITUENTS ; SPORES
英文摘要:

Triterpenoids are the main bioactive components of Ganoderma lucidum, a famous traditional Chinese medicine. After oral administration of total triterpenoids of G. lucidum (TTGL), the rat bile was analyzed by high-performance liquid chromatography coupled with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MSn) and liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry (LC-ESI-IT-TOF/MS). From rat bile and TTGL samples, a total of 31 triterpenoids, including seven new compounds, were identified or tentatively characterized based on their fragmentation behaviors. Among them, 22 triterpenoids were identified from TTGL and 29 triterpenoids were detected from rat bile after oral administration of TTGL. The results indicated that the majority of triterpenoids detected in TTGL extract could be excreted through rat bile. It is the first report on excretion of total triterpenoids of G. lucidum in rat bile. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30701078
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000302208500005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58505
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
2.Dalian Med Univ, Sch Pharm, Dalian 116044, Peoples R China

Recommended Citation:
Guo, Xiao-Yu,Han, Jian,Ye, Min,et al. Identification of major compounds in rat bile after oral administration of total triterpenoids of Ganoderma lucidum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2012,63:29-39.
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