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Identification of major compounds in rat bile after oral administration of total triterpenoids of Ganoderma lucidum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry
Guo, Xiao-Yu1; Han, Jian1; Ye, Min1; Ma, Xiao-Chi2; Shen, Xuan1; Xue, Bin-Bin1; Che, Qing-Ming1
关键词Ganoderma lucidum Triterpenoids Metabolites HPLC-DAD-ESI-MSn LC-ESI-IT-TOF/MS
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2012-04-07
DOI10.1016/j.jpba.2012.01.030
63页:29-39
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]FR KARST ; QUANTITATIVE-DETERMINATION ; ACID-F ; TERPENOIDS ; CONSTITUENTS ; SPORES
英文摘要

Triterpenoids are the main bioactive components of Ganoderma lucidum, a famous traditional Chinese medicine. After oral administration of total triterpenoids of G. lucidum (TTGL), the rat bile was analyzed by high-performance liquid chromatography coupled with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MSn) and liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry (LC-ESI-IT-TOF/MS). From rat bile and TTGL samples, a total of 31 triterpenoids, including seven new compounds, were identified or tentatively characterized based on their fragmentation behaviors. Among them, 22 triterpenoids were identified from TTGL and 29 triterpenoids were detected from rat bile after oral administration of TTGL. The results indicated that the majority of triterpenoids detected in TTGL extract could be excreted through rat bile. It is the first report on excretion of total triterpenoids of G. lucidum in rat bile. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
所属项目编号30701078
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000302208500005
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58505
专题北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
2.Dalian Med Univ, Sch Pharm, Dalian 116044, Peoples R China
推荐引用方式
GB/T 7714
Guo, Xiao-Yu,Han, Jian,Ye, Min,et al. Identification of major compounds in rat bile after oral administration of total triterpenoids of Ganoderma lucidum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2012,63:29-39.
APA Guo, Xiao-Yu.,Han, Jian.,Ye, Min.,Ma, Xiao-Chi.,Shen, Xuan.,...&Che, Qing-Ming.(2012).Identification of major compounds in rat bile after oral administration of total triterpenoids of Ganoderma lucidum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,63,29-39.
MLA Guo, Xiao-Yu,et al."Identification of major compounds in rat bile after oral administration of total triterpenoids of Ganoderma lucidum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 63(2012):29-39.
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