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学科主题临床医学
Expression of CD62L on Donor CD4(+) T Cells in Allografts: Correlation with Graft-Versus-Host Disease after Unmanipulated Allogeneic Blood and Marrow Transplantation
Chang, Ying-Jun; Zhao, Xiang-Yu; Huo, Ming-Rui; Huang, Xiao-Jun
关键词CD4(+) cells graft-versus-host disease allogeneic blood and marrow transplantation CD62L
刊名JOURNAL OF CLINICAL IMMUNOLOGY
2009-09-01
DOI10.1007/s10875-009-9293-9
29期:5页:696-704
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]COLONY-STIMULATING FACTOR ; STEM-CELL ; PERIPHERAL-BLOOD ; G-CSF ; ALLOANTIGEN STIMULATION ; ANTITHYMOCYTE GLOBULIN ; HEALTHY-INDIVIDUALS ; LYMPHOCYTE FUNCTION ; L-SELECTIN ; HYPORESPONSIVENESS
英文摘要

The aim of this study was to investigate the association of donor CD4(+) T cells expressing CD62L with transplant outcomes.

We report a prospective analysis of 31 patients who were treated with a Bu/Cy regimen, followed by unmanipulated blood and marrow transplantation.

Median number (range) of CD4(+)CD62L(+), CD4(+)CD45RA(+)CD62L(+), and CD4(+)CD45RO(+)CD62L(+) cells infused were 0.31(0.05-1.10)x10(8)/kg, 0.22(0.03-0.95)x 10(8)/kg, and 0.17(0.01-0.81)x10(8)/kg, respectively. The incidence of grades II to IV aGVHD was 36%. In a multivariate analysis, infusion of > 0.22 x 10(8) CD4(+)CD45RA(+)CD62L(+) cells infused/kg increased the risk of grades II to IV aGVHD (HR = 4.741, 95% CI = 1.037-21.662, P = 0.045). Thirteen of 31 patients experienced cGVHD, the risk of cGVHD was increased in patients receiving > 0.45 x 10(8) CD4(+)CD45RA(+) cells infused/kg (HR = 4.614, 95% CI = 1.265-16.829, P = 0.021).

Our results suggest that a high cell dose of CD4(+)CD45RA(+)CD62L(+) cells increase the incidence of grades II-IV aGVHD. A high number of CD4(+)CD45RA(+) cells infused were associated with increased risk of cGVHD in our transplant settings.

语种英语
WOS记录号WOS:000269151400016
项目编号30725038 ; 2006AA02Z4A0 ; IRT0702
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; Hi-Tech Research and Development Program of China ; Program for Innovative Research Team in University
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58518
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Chang, Ying-Jun,Zhao, Xiang-Yu,Huo, Ming-Rui,et al. Expression of CD62L on Donor CD4(+) T Cells in Allografts: Correlation with Graft-Versus-Host Disease after Unmanipulated Allogeneic Blood and Marrow Transplantation[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2009,29(5):696-704.
APA Chang, Ying-Jun,Zhao, Xiang-Yu,Huo, Ming-Rui,&Huang, Xiao-Jun.(2009).Expression of CD62L on Donor CD4(+) T Cells in Allografts: Correlation with Graft-Versus-Host Disease after Unmanipulated Allogeneic Blood and Marrow Transplantation.JOURNAL OF CLINICAL IMMUNOLOGY,29(5),696-704.
MLA Chang, Ying-Jun,et al."Expression of CD62L on Donor CD4(+) T Cells in Allografts: Correlation with Graft-Versus-Host Disease after Unmanipulated Allogeneic Blood and Marrow Transplantation".JOURNAL OF CLINICAL IMMUNOLOGY 29.5(2009):696-704.
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