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学科主题: 临床医学
题名:
Xuezhikang, Extract of Red Yeast Rice, Improved Abnormal Hemorheology, Suppressed Caveolin-1 and Increased eNOS Expression in Atherosclerotic Rats
作者: Zhu, Xin-Yuan; Li, Pei; Yang, Ya-Bing; Liu, Mei-Lin
刊名: PLOS ONE
发表日期: 2013-05-10
DOI: 10.1371/journal.pone.0062731
卷: 8, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; BLOOD-CELL DEFORMABILITY ; CORONARY-HEART-DISEASE ; MYOCARDIAL-INFARCTION ; VASCULAR-DISEASE ; STABLE ANGINA ; ERYTHROCYTES ; VISCOSITY ; AORTA ; MICE
英文摘要:

Background: Xuezhikang is the extract of red yeast rice, which has been widely used for the management of atherosclerotic disease, but the molecular basis of its antiatherosclerotic effects has not yet been fully identified. Here we investigated the changes of eNOS in vascular endothelia and RBCs, eNOS regulatory factor Caveolin-1 in endothelia, and hemorheological parameters in atherosclerotic rats to explore the protective effects of Xuezhikang.

Methodology/Principal Findings: Wistar rats were divided into 4 groups (n = 12/group) group C, controls; group M, high-cholesterol diet (HCD) induced atherosclerotic models; group X, HCD+Xuezhikang; and group L, HCD+Lovastatin. In group X, Xuezhikang inhibited oxidative stress, down-regulated caveolin-1 in aorta wall (P<0.05), up-regulated eNOS expression in vascular endothelia and erythrocytes (P<0.05), increased NOx (nitrite and nitrate) in plasma and cGMP in erythrocyte plasma and aorta wall (P<0.05), increased erythrocyte deformation index (EDI), and decreased whole blood viscosity and plasma viscosity (P<0.05), with the improvement of arterial pathology.

Conclusions/Significance: Xuezhikang up-regulated eNOS expression in vascular endothelia and RBCs, increased plasma NOx and improved abnormal hemorheology in high cholesterol diet induced atherosclerotic rats. The elevated eNOS/NO and improved hemorheology may be beneficial to atherosclerotic disease.

语种: 英语
项目资助者: China Health &amp ; Medical Development Foundation
WOS记录号: WOS:000318852400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58524
Appears in Collections:北京大学第一临床医学院_老年病内科_期刊论文

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作者单位: Peking Univ, Dept Geriatr, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Zhu, Xin-Yuan,Li, Pei,Yang, Ya-Bing,et al. Xuezhikang, Extract of Red Yeast Rice, Improved Abnormal Hemorheology, Suppressed Caveolin-1 and Increased eNOS Expression in Atherosclerotic Rats[J]. PLOS ONE,2013,8(5).
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