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Xuezhikang, Extract of Red Yeast Rice, Improved Abnormal Hemorheology, Suppressed Caveolin-1 and Increased eNOS Expression in Atherosclerotic Rats
Zhu, Xin-Yuan; Li, Pei; Yang, Ya-Bing; Liu, Mei-Lin
刊名PLOS ONE
2013-05-10
DOI10.1371/journal.pone.0062731
8期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者China Health &amp ; Medical Development Foundation ; China Health &amp ; Medical Development Foundation
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]NITRIC-OXIDE SYNTHASE ; BLOOD-CELL DEFORMABILITY ; CORONARY-HEART-DISEASE ; MYOCARDIAL-INFARCTION ; VASCULAR-DISEASE ; STABLE ANGINA ; ERYTHROCYTES ; VISCOSITY ; AORTA ; MICE
英文摘要

Background: Xuezhikang is the extract of red yeast rice, which has been widely used for the management of atherosclerotic disease, but the molecular basis of its antiatherosclerotic effects has not yet been fully identified. Here we investigated the changes of eNOS in vascular endothelia and RBCs, eNOS regulatory factor Caveolin-1 in endothelia, and hemorheological parameters in atherosclerotic rats to explore the protective effects of Xuezhikang.

Methodology/Principal Findings: Wistar rats were divided into 4 groups (n = 12/group) group C, controls; group M, high-cholesterol diet (HCD) induced atherosclerotic models; group X, HCD+Xuezhikang; and group L, HCD+Lovastatin. In group X, Xuezhikang inhibited oxidative stress, down-regulated caveolin-1 in aorta wall (P<0.05), up-regulated eNOS expression in vascular endothelia and erythrocytes (P<0.05), increased NOx (nitrite and nitrate) in plasma and cGMP in erythrocyte plasma and aorta wall (P<0.05), increased erythrocyte deformation index (EDI), and decreased whole blood viscosity and plasma viscosity (P<0.05), with the improvement of arterial pathology.

Conclusions/Significance: Xuezhikang up-regulated eNOS expression in vascular endothelia and RBCs, increased plasma NOx and improved abnormal hemorheology in high cholesterol diet induced atherosclerotic rats. The elevated eNOS/NO and improved hemorheology may be beneficial to atherosclerotic disease.

语种英语
资助者China Health &amp ; Medical Development Foundation ; China Health &amp ; Medical Development Foundation
WOS记录号WOS:000318852400008
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58524
专题北京大学第一临床医学院_老年病内科
作者单位Peking Univ, Dept Geriatr, Hosp 1, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Xin-Yuan,Li, Pei,Yang, Ya-Bing,et al. Xuezhikang, Extract of Red Yeast Rice, Improved Abnormal Hemorheology, Suppressed Caveolin-1 and Increased eNOS Expression in Atherosclerotic Rats[J]. PLOS ONE,2013,8(5).
APA Zhu, Xin-Yuan,Li, Pei,Yang, Ya-Bing,&Liu, Mei-Lin.(2013).Xuezhikang, Extract of Red Yeast Rice, Improved Abnormal Hemorheology, Suppressed Caveolin-1 and Increased eNOS Expression in Atherosclerotic Rats.PLOS ONE,8(5).
MLA Zhu, Xin-Yuan,et al."Xuezhikang, Extract of Red Yeast Rice, Improved Abnormal Hemorheology, Suppressed Caveolin-1 and Increased eNOS Expression in Atherosclerotic Rats".PLOS ONE 8.5(2013).
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