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学科主题临床医学
Circulating neuregulin-1 beta levels vary according to the angiographic severity of coronary artery disease and ischemia
Geisberg, Carrie Anna1; Wang, Guisong4; Safa, Radwan N.1,3; Smith, Holly M.1; Anderson, Brent1; Peng, Xu-Yang1; Veerkamp, Brian1; Zhao, David X.1; Blakemore, Dana2; Yu, Chang2; Sawyer, Douglas B.1
关键词atherosclerosis biomarkers growth factors neuregulin stress-induced ischemia
刊名CORONARY ARTERY DISEASE
2011-12-01
DOI10.1097/MCA.0b013e32834d3346
22期:8页:577-582
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; HEART-FAILURE ; EXPRESSION ; HEREGULIN ; PLASMA ; VEGF ; ATHEROSCLEROSIS ; CELLS
英文摘要

Background Coronary artery disease (CAD) is the leading killer in the United States. Patients with severe CAD and ischemia have worse prognosis. Therefore expansion of biomarker research, to identify at-risk individuals and explain the complex biology between cardiovascular growth factors and atherosclerosis is needed. Neuregulin-1 beta (NRG-1 beta) is a myocardial stress activated growth and survival factor released from endocardial and endothelial cells. NRG-1 beta is essential for cardiovascular development and a regulator of angiogenesis. We postulated that plasma and serum levels of NRG-1 beta would vary in relation to CAD severity and the presence of stress-induced ischemia.

Methods We measured serum and plasma levels of NRG-1 beta and vascular endothelial growth factor (VEGF) in 60 patients undergoing cardiac catheterization. CAD severity was calculated from angiographic results using a modified Duke jeopardy score.

Results Serum NRG-1 beta (sNRG-1 beta), plasma NRG-1 beta (pNRG-1 beta), serum VEGF, and plasma VEGF were detectable in the majority of patients. The pNRG-1 beta levels were approximately two-fold higher than sNRG-1 beta. Both sNRG-1 beta and pNRG-1 beta correlated inversely with CAD severity. pNRG-1 beta levels were statistically higher in patients with stress-induced ischemia denoted by a positive myocardial perfusion imaging study that correlated with angiographic findings (P = 0.02).

Conclusion Both sNRG-1 beta and pNRG-1 beta correlated inversely with angiographic severity of CAD. pNRG-1 beta levels were two-fold higher than serum and were higher in patients with stress-induced ischemia. Therefore we conclude that plasma is the optimal source for the further exploration of the biological significance of NRG-1 beta as a biomarker of CAD severity and ischemia. Coron Artery Dis 22: 577-582 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000296844400010
项目编号HL068144 ; 1 UL1 RR024975
资助机构American Heart Association, Dallas, Texas, USA ; Heart Failure Society of America, Saint Paul, Minnesota, USA ; NCRR/NIH, Nashville, Tennessee, USA
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58525
专题北京大学第三临床医学院_心血管内科
作者单位1.Vanderbilt Univ, Sch Med, Div Cardiovasc Med, Nashville, TN 37232 USA
2.Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37232 USA
3.Boston Univ, Sch Med, Boston, MA 02118 USA
4.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100871, Peoples R China
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Geisberg, Carrie Anna,Wang, Guisong,Safa, Radwan N.,et al. Circulating neuregulin-1 beta levels vary according to the angiographic severity of coronary artery disease and ischemia[J]. CORONARY ARTERY DISEASE,2011,22(8):577-582.
APA Geisberg, Carrie Anna.,Wang, Guisong.,Safa, Radwan N..,Smith, Holly M..,Anderson, Brent.,...&Sawyer, Douglas B..(2011).Circulating neuregulin-1 beta levels vary according to the angiographic severity of coronary artery disease and ischemia.CORONARY ARTERY DISEASE,22(8),577-582.
MLA Geisberg, Carrie Anna,et al."Circulating neuregulin-1 beta levels vary according to the angiographic severity of coronary artery disease and ischemia".CORONARY ARTERY DISEASE 22.8(2011):577-582.
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