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IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Circulating neuregulin-1 beta levels vary according to the angiographic severity of coronary artery disease and ischemia
作者: Geisberg, Carrie Anna1; Wang, Guisong4; Safa, Radwan N.1,3; Smith, Holly M.1; Anderson, Brent1; Peng, Xu-Yang1; Veerkamp, Brian1; Zhao, David X.1; Blakemore, Dana2; Yu, Chang2; Sawyer, Douglas B.1
关键词: atherosclerosis ; biomarkers ; growth factors ; neuregulin ; stress-induced ischemia
刊名: CORONARY ARTERY DISEASE
发表日期: 2011-12-01
DOI: 10.1097/MCA.0b013e32834d3346
卷: 22, 期:8, 页:577-582
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; HEART-FAILURE ; EXPRESSION ; HEREGULIN ; PLASMA ; VEGF ; ATHEROSCLEROSIS ; CELLS
英文摘要:

Background Coronary artery disease (CAD) is the leading killer in the United States. Patients with severe CAD and ischemia have worse prognosis. Therefore expansion of biomarker research, to identify at-risk individuals and explain the complex biology between cardiovascular growth factors and atherosclerosis is needed. Neuregulin-1 beta (NRG-1 beta) is a myocardial stress activated growth and survival factor released from endocardial and endothelial cells. NRG-1 beta is essential for cardiovascular development and a regulator of angiogenesis. We postulated that plasma and serum levels of NRG-1 beta would vary in relation to CAD severity and the presence of stress-induced ischemia.

Methods We measured serum and plasma levels of NRG-1 beta and vascular endothelial growth factor (VEGF) in 60 patients undergoing cardiac catheterization. CAD severity was calculated from angiographic results using a modified Duke jeopardy score.

Results Serum NRG-1 beta (sNRG-1 beta), plasma NRG-1 beta (pNRG-1 beta), serum VEGF, and plasma VEGF were detectable in the majority of patients. The pNRG-1 beta levels were approximately two-fold higher than sNRG-1 beta. Both sNRG-1 beta and pNRG-1 beta correlated inversely with CAD severity. pNRG-1 beta levels were statistically higher in patients with stress-induced ischemia denoted by a positive myocardial perfusion imaging study that correlated with angiographic findings (P = 0.02).

Conclusion Both sNRG-1 beta and pNRG-1 beta correlated inversely with angiographic severity of CAD. pNRG-1 beta levels were two-fold higher than serum and were higher in patients with stress-induced ischemia. Therefore we conclude that plasma is the optimal source for the further exploration of the biological significance of NRG-1 beta as a biomarker of CAD severity and ischemia. Coron Artery Dis 22: 577-582 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: HL068144 ; 1 UL1 RR024975
项目资助者: American Heart Association, Dallas, Texas, USA ; Heart Failure Society of America, Saint Paul, Minnesota, USA ; NCRR/NIH, Nashville, Tennessee, USA
WOS记录号: WOS:000296844400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58525
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Vanderbilt Univ, Sch Med, Div Cardiovasc Med, Nashville, TN 37232 USA
2.Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37232 USA
3.Boston Univ, Sch Med, Boston, MA 02118 USA
4.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100871, Peoples R China

Recommended Citation:
Geisberg, Carrie Anna,Wang, Guisong,Safa, Radwan N.,et al. Circulating neuregulin-1 beta levels vary according to the angiographic severity of coronary artery disease and ischemia[J]. CORONARY ARTERY DISEASE,2011,22(8):577-582.
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