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Expression of integrin beta 3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window
Xiao, Yu1,2,3,4; Li, Tinchiu2,3; Xia, Enlan4; Yang, Xiuli1; Sun, Xiao1; Zhou, Yingfang1
关键词Integrin beta 3 Osteopontin Adenomyosis Endometriosis Implantation window
刊名EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
2013-10-01
DOI10.1016/j.ejogrb.2013.05.007
170期:2页:419-422
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]RECEPTIVITY ; WOMEN ; INFERTILE
英文摘要

Objective: To investigate the expression of integrin beta 3 and osteopontin (OPN) in the eutopic endometrium of adenomyosis and to characterize possible endometrial defects in adenomyosis.

Study design: Twenty-eight adenomyosis patients and 27 control fertile women were involved in this study. Endometrial samples were collected during the implantation window. Integrin beta 3 subunits and OPN in the adenomyosis and control endometria were assessed by immunohistochemical staining and quantitative real-time polymerase chain reaction. A one-tailed t-test and a non-parametric Mann-Whitney U-test were used to test significance.

Results: The mRNA and immunostaining intensity of integrin beta 3 and OPN were significantly lower in the adenomyosis patients than in the controls.

Conclusions: Abnormal expression of integrin beta 3 and OPN in the endometrium of adenomyosis may contribute to infertility in some patients. (C) 2013 Published by Elsevier Ireland Ltd.

语种英语
WOS记录号WOS:000326009000024
项目编号20110050
资助机构XiCheng District Outstanding Asset Fund of Beijing
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58526
专题北京大学第一临床医学院
北京大学医学部管理机构_科学研究处
北京大学第一临床医学院_妇产科
作者单位1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100038, Peoples R China
2.Sheffield Teaching Hosp, Dept Obstet & Gynaecol, Sheffield S10 2SF, S Yorkshire, England
3.Sheffield Hallam Univ, Sheffield S10 2SF, S Yorkshire, England
4.Capital Med Univ, Fuxing Hosp, Hysterosop Ctr, Beijing 100038, Peoples R China
推荐引用方式
GB/T 7714
Xiao, Yu,Li, Tinchiu,Xia, Enlan,et al. Expression of integrin beta 3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window[J]. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY,2013,170(2):419-422.
APA Xiao, Yu,Li, Tinchiu,Xia, Enlan,Yang, Xiuli,Sun, Xiao,&Zhou, Yingfang.(2013).Expression of integrin beta 3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window.EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY,170(2),419-422.
MLA Xiao, Yu,et al."Expression of integrin beta 3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window".EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 170.2(2013):419-422.
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