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学科主题: 临床医学
题名:
Expression of integrin beta 3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window
作者: Xiao, Yu1,2,3,4; Li, Tinchiu2,3; Xia, Enlan4; Yang, Xiuli1; Sun, Xiao1; Zhou, Yingfang1
关键词: Integrin beta 3 ; Osteopontin ; Adenomyosis ; Endometriosis ; Implantation window
刊名: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
发表日期: 2013-10-01
DOI: 10.1016/j.ejogrb.2013.05.007
卷: 170, 期:2, 页:419-422
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: RECEPTIVITY ; WOMEN ; INFERTILE
英文摘要:

Objective: To investigate the expression of integrin beta 3 and osteopontin (OPN) in the eutopic endometrium of adenomyosis and to characterize possible endometrial defects in adenomyosis.

Study design: Twenty-eight adenomyosis patients and 27 control fertile women were involved in this study. Endometrial samples were collected during the implantation window. Integrin beta 3 subunits and OPN in the adenomyosis and control endometria were assessed by immunohistochemical staining and quantitative real-time polymerase chain reaction. A one-tailed t-test and a non-parametric Mann-Whitney U-test were used to test significance.

Results: The mRNA and immunostaining intensity of integrin beta 3 and OPN were significantly lower in the adenomyosis patients than in the controls.

Conclusions: Abnormal expression of integrin beta 3 and OPN in the endometrium of adenomyosis may contribute to infertility in some patients. (C) 2013 Published by Elsevier Ireland Ltd.

语种: 英语
所属项目编号: 20110050
项目资助者: XiCheng District Outstanding Asset Fund of Beijing
WOS记录号: WOS:000326009000024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58526
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100038, Peoples R China
2.Sheffield Teaching Hosp, Dept Obstet & Gynaecol, Sheffield S10 2SF, S Yorkshire, England
3.Sheffield Hallam Univ, Sheffield S10 2SF, S Yorkshire, England
4.Capital Med Univ, Fuxing Hosp, Hysterosop Ctr, Beijing 100038, Peoples R China

Recommended Citation:
Xiao, Yu,Li, Tinchiu,Xia, Enlan,et al. Expression of integrin beta 3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window[J]. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY,2013,170(2):419-422.
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