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学科主题: 基础医学
题名:
Protective effects of 3,4-dihydroxyphenyl lactic acid on lipopolysaccharide-induced cerebral microcirculatory disturbance in mice
作者: Li, Yu-Juan1; Han, Dong2; Xu, Xiang-Shun2; Liu, Yu-Ying2; Sun, Kai2; Fan, Jing-Yu2; Qian, Rui-Qin1; Han, Jing-Yan1,2
关键词: Brain ; lipopolysacchride ; TNF-alpha ; vascular permeability ; intravital microscopy
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2012
DOI: 10.3233/CH-2011-1435
卷: 50, 期:4, 页:267-278
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: ENDOTHELIAL-CELL PERMEABILITY ; RAT MESENTERY ; SALVIA-MILTIORRHIZA ; ADHESION ; ENDOTOXEMIA ; REPERFUSION ; TNF ; EXPRESSION ; ISCHEMIA ; EXTRACT
英文摘要:

This study intended to examine the effect of 3,4-dihydroxyphenyl lactic acid (DLA), a major ingredient of Salvia miltiorrhiza, on lipopolysaccahride (LPS) -induced mouse cerebral cortical microcirculatory disturbance. Velocity of red blood cells in, and albumin leakage from venules, and the numbers of leukocytes rolling on, and adherent to the venular wall were determined by an up-right microscope after LPS (5 mg/kg/h) infusion with or without administration of DLA (5 mg/kg/h). Expression of adhesion molecules CD11b/CD18 and L-selectin on neutrophils, plasma concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were evaluated by flow cytometry. Concentration of TNF-alpha in supernatants of LPS-stimulated mononuclear cells was evaluated in vitro by flow cytometry as well. LPS exposure significantly increased the number of rolling and adherent leukocytes as well as albumin leakage, and decreased the velocity of red blood cells in venules. In addition, LPS stimulation apparently increased the expression of CD11b/CD18 on neutrophils, the concentration of plasma TNF-alpha, and the production of TNF-alpha from mononuclear cells. Treatment with DLA significantly ameliorated LPS-induced insults in mice, including cerebral microcirculatory disturbance, the expression of CD11b/CD18 on neutrophils, and the increased concentration of plasma TNF-alpha and the production of TNF-alpha from mononuclear cells.

语种: 英语
所属项目编号: 2008ZX09401
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000303443300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58538
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Li, Yu-Juan,Han, Dong,Xu, Xiang-Shun,et al. Protective effects of 3,4-dihydroxyphenyl lactic acid on lipopolysaccharide-induced cerebral microcirculatory disturbance in mice[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2012,50(4):267-278.
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