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Protective effects of 3,4-dihydroxyphenyl lactic acid on lipopolysaccharide-induced cerebral microcirculatory disturbance in mice
Li, Yu-Juan1; Han, Dong2; Xu, Xiang-Shun2; Liu, Yu-Ying2; Sun, Kai2; Fan, Jing-Yu2; Qian, Rui-Qin1; Han, Jing-Yan1,2
关键词Brain lipopolysacchride TNF-alpha vascular permeability intravital microscopy
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2012
DOI10.3233/CH-2011-1435
50期:4页:267-278
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]ENDOTHELIAL-CELL PERMEABILITY ; RAT MESENTERY ; SALVIA-MILTIORRHIZA ; ADHESION ; ENDOTOXEMIA ; REPERFUSION ; TNF ; EXPRESSION ; ISCHEMIA ; EXTRACT
英文摘要

This study intended to examine the effect of 3,4-dihydroxyphenyl lactic acid (DLA), a major ingredient of Salvia miltiorrhiza, on lipopolysaccahride (LPS) -induced mouse cerebral cortical microcirculatory disturbance. Velocity of red blood cells in, and albumin leakage from venules, and the numbers of leukocytes rolling on, and adherent to the venular wall were determined by an up-right microscope after LPS (5 mg/kg/h) infusion with or without administration of DLA (5 mg/kg/h). Expression of adhesion molecules CD11b/CD18 and L-selectin on neutrophils, plasma concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were evaluated by flow cytometry. Concentration of TNF-alpha in supernatants of LPS-stimulated mononuclear cells was evaluated in vitro by flow cytometry as well. LPS exposure significantly increased the number of rolling and adherent leukocytes as well as albumin leakage, and decreased the velocity of red blood cells in venules. In addition, LPS stimulation apparently increased the expression of CD11b/CD18 on neutrophils, the concentration of plasma TNF-alpha, and the production of TNF-alpha from mononuclear cells. Treatment with DLA significantly ameliorated LPS-induced insults in mice, including cerebral microcirculatory disturbance, the expression of CD11b/CD18 on neutrophils, and the increased concentration of plasma TNF-alpha and the production of TNF-alpha from mononuclear cells.

语种英语
所属项目编号2008ZX09401
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000303443300004
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58538
专题基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Yu-Juan,Han, Dong,Xu, Xiang-Shun,et al. Protective effects of 3,4-dihydroxyphenyl lactic acid on lipopolysaccharide-induced cerebral microcirculatory disturbance in mice[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2012,50(4):267-278.
APA Li, Yu-Juan.,Han, Dong.,Xu, Xiang-Shun.,Liu, Yu-Ying.,Sun, Kai.,...&Han, Jing-Yan.(2012).Protective effects of 3,4-dihydroxyphenyl lactic acid on lipopolysaccharide-induced cerebral microcirculatory disturbance in mice.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,50(4),267-278.
MLA Li, Yu-Juan,et al."Protective effects of 3,4-dihydroxyphenyl lactic acid on lipopolysaccharide-induced cerebral microcirculatory disturbance in mice".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 50.4(2012):267-278.
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