北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 期刊论文
学科主题: 基础医学
题名:
Bone tissue engineering using bone marrow stromal cells and an injectable sodium alginate/gelatin scaffold
作者: Xia, Yang1,2; Mei, Fang1; Duan, Yongli2; Gao, Ying2; Xiong, Zhuo3; Zhang, Ting3; Zhang, Hongquan1
关键词: sodium alginate ; gelatin ; BMSCs ; osteogenic cells ; ectopic bone formation ; calvarial critical-sized defects
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
发表日期: 2012-04-01
DOI: 10.1002/jbm.a.33232
卷: 100A, 期:4, 页:1044-1050
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: MESENCHYMAL STEM-CELLS ; CRITICAL SIZE DEFECT ; FABRICATION ; HYDROGELS ; MODEL
英文摘要:

To investigate the potential application of bone marrow stromal cells (BMSCs) and an injectable sodium alginate/gelatin scaffold for bone tissue engineering (BTE). The phenotype of osteogenic BMSCs was examined by mineralized nodules formation and type I collagen expression. Cell proliferation was evaluated by MTT assay. The biocompatibility of scaffold and osteogenic cells were examined by hematoxylin and eosin (H&E) staining. Ectopic bone formation as well as closure of rabbit calvarial critical-sized defects following scaffold-cell implantation were analyzed by histological examination and computed tomography (CT) scanning. Spindle-shaped osteogenic cells of high purity were derived from BMSCs. The osteogenic cells and sodium alginate/gelatin (2:3) scaffold presented fine biocompatibility following cross-linking with 0.6% of CaCl2. After implantation, the scaffold-cell construct promoted both ectopic bone formation and bone healing in the rabbit calvarial critical-sized defect model. Our data demonstrated that the sodium alginate/gelatin scaffold could be a suitable biomaterial for bone engineering, and the scaffold-osteogenic cells construct is a promising alternative approach for the bone healing process. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.

语种: 英语
所属项目编号: 7083107 ; 20071D0303100116 ; 20090460179 ; 30830048 ; 2010CB912203
项目资助者: Beijing Natural Science Foundation ; Beijing Excellent Researcher Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; State Key Development Program of Basic Research of China
WOS记录号: WOS:000300677600024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58544
Appears in Collections:基础医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Beijing Shijitan Hosp, Beijing 100038, Peoples R China
3.Tsinghua Univ, Dept Mech Engn, Beijing 100084, Peoples R China

Recommended Citation:
Xia, Yang,Mei, Fang,Duan, Yongli,et al. Bone tissue engineering using bone marrow stromal cells and an injectable sodium alginate/gelatin scaffold[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2012,100A(4):1044-1050.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xia, Yang]'s Articles
[Mei, Fang]'s Articles
[Duan, Yongli]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xia, Yang]‘s Articles
[Mei, Fang]‘s Articles
[Duan, Yongli]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace