北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学口腔医学院  > 牙周科  > 期刊论文
学科主题: 口腔医学
题名:
Leptin and its receptor expression in dental and periodontal tissues of primates
作者: Li, Wei1; Zhu, Weidong1; Hou, Jianxia1; Huang, Baoxin2; Liu, Kaining1; Meng, Huanxin1
关键词: Leptin ; OBR ; Dental and periodontal tissue ; Immunohistochemistry ; Primate ; Macaca fascicularis ; Human
刊名: CELL AND TISSUE RESEARCH
发表日期: 2014
DOI: 10.1007/s00441-013-1729-0
卷: 355, 期:1, 页:181-188
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: GINGIVAL CREVICULAR FLUID ; LIGAMENT FIBROBLASTS ; PLASMA LEPTIN ; SERUM LEPTIN ; STEM-CELLS ; DIFFERENTIATION ; OSTEOBLASTS ; DISEASE ; BONE ; GENE
英文摘要:

Leptin and its receptor (OBR) have attracted much attention since their discovery. They have been reported to play central roles in energy balance, the immune-inflammatory response and bone metabolism. Evidence indicates that leptin and OBR are associated with inflammatory diseases of dental and periodontal tissues. The first step for establishing this is to determine the expression of leptin and OBR in these tissues. Our study is the first to examine systematically the expression of leptin and OBR in dental and periodontal tissues of monkeys (Macaca fascicularis) by immunohistochemistry and in primary cultured cells, isolated from human dental and periodontal tissues, by reverse transcription plus the polymerase chain reaction and immunocytochemistry. Our results show that leptin and OBR are constitutively expressed and widely distributed in dental and periodontal tissues of primates. Their immunoreaction is especially strong in junctional epithelium, a unique front-line defense around teeth and in mineralizing areas of the dental pulp and periodontal ligament. The expression of the long and also functional form of OBR (OBRb) indicates that leptin has a direct effect on these cells. Thus, we can reasonably infer that leptin and OBR exert effects on defense, mineralization and angiogenesis in dental and periodontal tissues of primates.

语种: 英语
所属项目编号: 30600705 ; 81271149 ; PKUSS20130111
项目资助者: National Natural Science Foundation of China ; Key Project for Clinical Faculty Foundation, Ministry of Health, China ; Peking University School of Stomatology
WOS记录号: WOS:000329581700015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58552
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
2.Sun Yat Sen Univ, Guangdong Prov Key Lab Stomatol, Hosp Stomatol, Guanghua Sch Stomatol, Guangzhou 510055, Guangdong, Peoples R China

Recommended Citation:
Li, Wei,Zhu, Weidong,Hou, Jianxia,et al. Leptin and its receptor expression in dental and periodontal tissues of primates[J]. CELL AND TISSUE RESEARCH,2014,355(1):181-188.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Wei]'s Articles
[Zhu, Weidong]'s Articles
[Hou, Jianxia]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Wei]‘s Articles
[Zhu, Weidong]‘s Articles
[Hou, Jianxia]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace