IR@PKUHSC  > 北京大学口腔医学院  > 牙周科
学科主题口腔医学
Leptin and its receptor expression in dental and periodontal tissues of primates
Li, Wei1; Zhu, Weidong1; Hou, Jianxia1; Huang, Baoxin2; Liu, Kaining1; Meng, Huanxin1
关键词Leptin OBR Dental and periodontal tissue Immunohistochemistry Primate Macaca fascicularis Human
刊名CELL AND TISSUE RESEARCH
2014
DOI10.1007/s00441-013-1729-0
355期:1页:181-188
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
资助者National Natural Science Foundation of China ; Key Project for Clinical Faculty Foundation, Ministry of Health, China ; Peking University School of Stomatology ; National Natural Science Foundation of China ; Key Project for Clinical Faculty Foundation, Ministry of Health, China ; Peking University School of Stomatology
研究领域[WOS]Cell Biology
关键词[WOS]GINGIVAL CREVICULAR FLUID ; LIGAMENT FIBROBLASTS ; PLASMA LEPTIN ; SERUM LEPTIN ; STEM-CELLS ; DIFFERENTIATION ; OSTEOBLASTS ; DISEASE ; BONE ; GENE
英文摘要

Leptin and its receptor (OBR) have attracted much attention since their discovery. They have been reported to play central roles in energy balance, the immune-inflammatory response and bone metabolism. Evidence indicates that leptin and OBR are associated with inflammatory diseases of dental and periodontal tissues. The first step for establishing this is to determine the expression of leptin and OBR in these tissues. Our study is the first to examine systematically the expression of leptin and OBR in dental and periodontal tissues of monkeys (Macaca fascicularis) by immunohistochemistry and in primary cultured cells, isolated from human dental and periodontal tissues, by reverse transcription plus the polymerase chain reaction and immunocytochemistry. Our results show that leptin and OBR are constitutively expressed and widely distributed in dental and periodontal tissues of primates. Their immunoreaction is especially strong in junctional epithelium, a unique front-line defense around teeth and in mineralizing areas of the dental pulp and periodontal ligament. The expression of the long and also functional form of OBR (OBRb) indicates that leptin has a direct effect on these cells. Thus, we can reasonably infer that leptin and OBR exert effects on defense, mineralization and angiogenesis in dental and periodontal tissues of primates.

语种英语
所属项目编号30600705 ; 81271149 ; PKUSS20130111
资助者National Natural Science Foundation of China ; Key Project for Clinical Faculty Foundation, Ministry of Health, China ; Peking University School of Stomatology ; National Natural Science Foundation of China ; Key Project for Clinical Faculty Foundation, Ministry of Health, China ; Peking University School of Stomatology
WOS记录号WOS:000329581700015
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58552
Collection北京大学口腔医学院_牙周科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
2.Sun Yat Sen Univ, Guangdong Prov Key Lab Stomatol, Hosp Stomatol, Guanghua Sch Stomatol, Guangzhou 510055, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Li, Wei,Zhu, Weidong,Hou, Jianxia,et al. Leptin and its receptor expression in dental and periodontal tissues of primates[J]. CELL AND TISSUE RESEARCH,2014,355(1):181-188.
APA Li, Wei,Zhu, Weidong,Hou, Jianxia,Huang, Baoxin,Liu, Kaining,&Meng, Huanxin.(2014).Leptin and its receptor expression in dental and periodontal tissues of primates.CELL AND TISSUE RESEARCH,355(1),181-188.
MLA Li, Wei,et al."Leptin and its receptor expression in dental and periodontal tissues of primates".CELL AND TISSUE RESEARCH 355.1(2014):181-188.
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