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学科主题: 公共卫生
题名:
Grape seed proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal muscle of low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
作者: Ding, Ye; Dai, Xiaoqian; Jiang, Yanfei; Zhang, Zhaofeng; Bao, Lei; Li, Yujie; Zhang, Feng; Ma, Xiaotao; Cai, Xiaxia; Jing, Lulu; Gu, Jiaojiao; Li, Yong
关键词: ER stress ; Grape seed proanthocyanidin extracts ; Oxidative stress ; Skeletal muscle ; Type 2 diabetes mellitus
刊名: MOLECULAR NUTRITION & FOOD RESEARCH
发表日期: 2013-02-01
DOI: 10.1002/mnfr.201200463
卷: 57, 期:2, 页:365-369
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology
研究领域[WOS]: Food Science & Technology
关键词[WOS]: ENDOPLASMIC-RETICULUM STRESS ; INSULIN-RESISTANCE ; DYSFUNCTION ; INDUCTION ; CELLS
英文摘要:

Although ER stress in pancreas, liver, and adipose tissue was reported to be a novel event linked to the pathogenesis of type 2 diabetes mellitus, there is much less information on this event in skeletal muscle. Some studies indicated that treatment with antioxidants had beneficial effects on ER stress and diabetes. This study focuses on the effects of a strong antioxidant, grape seed proanthocyanidin extracts (GSPE), on skeletal muscle in diabetic rats induced with low dose streptozotocin- and a high-carbohydrate/high-fat diet. After 16 wk of GSPE treatment, diabetic rats showed decreased plasma glucose levels and insulin resistance. The efficacious effect of GSPE was manifested by the amelioration of muscular damage and dysfunction, as observed by histological examination and periodic acid Schiff staining. Concurrently, calcium overload and the abnormal activities of antioxidant enzymes and ATPases in diabetic muscles were partially reversed by GSPE treatment. GSPE also increased the activity of protein kinase B (a mediator of insulin′s metabolic action) and partially alleviated severe ER stress. These findings suggest that GSPE may have auxiliary therapeutic potential for type 2 diabetes mellitus by decreasing oxidative stress and ER stress in skeletal muscle.

语种: 英语
所属项目编号: 81072293
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000313910200017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58555
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China

Recommended Citation:
Ding, Ye,Dai, Xiaoqian,Jiang, Yanfei,et al. Grape seed proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal muscle of low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats[J]. MOLECULAR NUTRITION & FOOD RESEARCH,2013,57(2):365-369.
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