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Grape seed proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal muscle of low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
Ding, Ye; Dai, Xiaoqian; Jiang, Yanfei; Zhang, Zhaofeng; Bao, Lei; Li, Yujie; Zhang, Feng; Ma, Xiaotao; Cai, Xiaxia; Jing, Lulu; Gu, Jiaojiao; Li, Yong
关键词ER stress Grape seed proanthocyanidin extracts Oxidative stress Skeletal muscle Type 2 diabetes mellitus
刊名MOLECULAR NUTRITION & FOOD RESEARCH
2013-02-01
DOI10.1002/mnfr.201200463
57期:2页:365-369
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Food Science & Technology
研究领域[WOS]Food Science & Technology
关键词[WOS]ENDOPLASMIC-RETICULUM STRESS ; INSULIN-RESISTANCE ; DYSFUNCTION ; INDUCTION ; CELLS
英文摘要

Although ER stress in pancreas, liver, and adipose tissue was reported to be a novel event linked to the pathogenesis of type 2 diabetes mellitus, there is much less information on this event in skeletal muscle. Some studies indicated that treatment with antioxidants had beneficial effects on ER stress and diabetes. This study focuses on the effects of a strong antioxidant, grape seed proanthocyanidin extracts (GSPE), on skeletal muscle in diabetic rats induced with low dose streptozotocin- and a high-carbohydrate/high-fat diet. After 16 wk of GSPE treatment, diabetic rats showed decreased plasma glucose levels and insulin resistance. The efficacious effect of GSPE was manifested by the amelioration of muscular damage and dysfunction, as observed by histological examination and periodic acid Schiff staining. Concurrently, calcium overload and the abnormal activities of antioxidant enzymes and ATPases in diabetic muscles were partially reversed by GSPE treatment. GSPE also increased the activity of protein kinase B (a mediator of insulin′s metabolic action) and partially alleviated severe ER stress. These findings suggest that GSPE may have auxiliary therapeutic potential for type 2 diabetes mellitus by decreasing oxidative stress and ER stress in skeletal muscle.

语种英语
WOS记录号WOS:000313910200017
项目编号81072293
资助机构National Natural Science Foundation of China
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58555
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
作者单位Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ding, Ye,Dai, Xiaoqian,Jiang, Yanfei,et al. Grape seed proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal muscle of low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats[J]. MOLECULAR NUTRITION & FOOD RESEARCH,2013,57(2):365-369.
APA Ding, Ye.,Dai, Xiaoqian.,Jiang, Yanfei.,Zhang, Zhaofeng.,Bao, Lei.,...&Li, Yong.(2013).Grape seed proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal muscle of low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats.MOLECULAR NUTRITION & FOOD RESEARCH,57(2),365-369.
MLA Ding, Ye,et al."Grape seed proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal muscle of low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats".MOLECULAR NUTRITION & FOOD RESEARCH 57.2(2013):365-369.
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