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学科主题: 口腔医学
题名:
Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK
作者: Chang, Jia; Sonoyama, Wataru; Wang, Zhuo; Jin, Qiming; Zhang, Chengfei; Krebsbach, Paul H.; Giannobile, William; Shi, Songtao; Wang, Cun-Yu
刊名: JOURNAL OF BIOLOGICAL CHEMISTRY
发表日期: 2007-10-19
DOI: 10.1074/jbc.M702391200
卷: 282, 期:42, 页:30938-30948
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: RECEPTOR-RELATED PROTEIN-5 ; SUPPRESSES OSTEOGENIC DIFFERENTIATION ; OSTEOBLAST DIFFERENTIATION ; BETA-CATENIN ; PROMOTES PROLIFERATION ; STROMAL CELLS ; MARROW ; CORECEPTOR ; EXPRESSION ; DICKKOPF-1
英文摘要:

Mesenchymal stem cells (MSCs) are multipotent cells that can be differentiated into osteoblasts and provide an excellent cell source for bone regeneration and repair. Recently, the canonical Wnt/beta-catenin signaling pathway has been found to play a critical role in skeletal development and osteogenesis, implying that Wnts can be utilized to improve de novo bone formation mediated by MSCs. However, it is unknown whether noncanonical Wnt signaling regulates osteogenic differentiation. Here, we find that Wnt-4 enhanced in vitro osteogenic differentiation of MSCs isolated from human adult craniofacial tissues and promoted bone formation in vivo. Whereas Wnt-4 did not stabilize beta-catenin, it activated p38 MAPK in a novel noncanonical signaling pathway. The activation of p38 was dependent on Axin and was required for the enhancement of MSC differentiation by Wnt-4. Moreover, using two different models of craniofacial bone injury, we found that MSCs genetically engineered to express Wnt-4 enhanced osteogenesis and improved the repair of craniofacial defects in vivo. Taken together, our results reveal that noncanonical Wnt signaling could also play a role in osteogenic differentiation. Wnt-4 may have a potential use in improving bone regeneration and repair of craniofacial defects.

语种: 英语
WOS记录号: WOS:000250136300062
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58556
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Univ Calif Los Angeles, Sch Dent, Div Oral Biol & Med, Lab Mol Signaling, Los Angeles, CA 90095 USA
2.Univ Michigan, Coll Engn, Dept Biomed Engn, Ann Arbor, MI 48109 USA
3.Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48109 USA
4.Univ Michigan, Sch Dent, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA
5.Peking Univ, Hlth Sci Ctr, Sch Stomatol, Beijing 100081, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Hosp Stomatol, Beijing 100081, Peoples R China
7.Univ So Calif, Sch Dent, Ctr Craniofacial Mol Biol, Los Angeles, CA 90033 USA

Recommended Citation:
Chang, Jia,Sonoyama, Wataru,Wang, Zhuo,et al. Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2007,282(42):30938-30948.
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