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学科主题: 临床医学
题名:
Donors with HLA-B*58:01/TNF alpha-308A haplotype are unfavorable to haploidentical hematopoietic stem cell transplantation in acute lymphoblastic leukemia
作者: Yang, Liyun1; Chen, Xue1; Liu, Hongxing2; Chen, Yan3; Zhao, Yiwen4; Bu, Dingfang5; Zhu, Ping1
关键词: HLA-B*58:01/TNF alpha-308A (B*58:01-TNF2) haplotype ; Haploidentical allergenic hematopoietic stem cell transplantation ; Acute lymphoblastic leukemia
刊名: TRANSPLANT IMMUNOLOGY
发表日期: 2015-03-01
DOI: 10.1016/j.trim.2014.12.003
卷: 32, 期:2, 页:92-98
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Transplantation
研究领域[WOS]: Immunology ; Transplantation
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; LEUKOCYTE ANTIGEN-A ; RISK ACUTE-LEUKEMIA ; TNF-ALPHA ; NASOPHARYNGEAL CARCINOMA ; ANKYLOSING-SPONDYLITIS ; LINKAGE DISEQUILIBRIUM ; PROMOTER REGION ; POLYMORPHISMS ; SUSCEPTIBILITY
英文摘要:

We investigated the clinical characteristics of acute lymphoblastic leukemia (ALL) patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) using haploidentical donors carrying HLA-B*58:01/TNF alpha - 308A (B*58:01-TNF2) haplotype. A total of 136 B-ALL and 29 T/NK-ALL cases were recruited. DNA samples from the patients and their family members were assayed for HLA typing and genotyping of TNF alpha - 308 (rs1800629). The B*58:01-TNF2 haplotype in related donors was determined by their family relationships. Outcomes within 2 years, disease course, and complications within 100 days were compared among patients using haploidentical donors carrying B*58:01-TNF2 haplotype (21 cases), those using haploidentical donors without B*58:01-TNF2 haplotype (100 cases), and those using HLA-identical sibling donors with or without B*58:01-TNF2 haplotype (44 cases). Compared with the other two groups, patients using haploidentical donors carrying B*58:01-TNF2 haplotype had higher overall mortality (adjusted P = 0.039) and non-relapse mortality (adjusted P = 0.001) within 2 years, delayed platelet engraftment (adjusted P < 0.0001), higher incidences of severe acute graft-versus-host disease (aGVHD) (P = 0.007), severe late-onset hemorrhagic cystitis (P = 0.002), blood stream infection (P = 0.017), and invasive fungal disease (P = 0.004) within 100 days. Therefore, donors carrying the B*58:01-THF2 haplotype may cause more serious complications and poorer outcomes to ALL recipients. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81370612 ; 2008AA02503
项目资助者: National Nature and Science Fund ; National 863 High-Tech Research and Development Program of China
WOS记录号: WOS:000353072800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58558
Appears in Collections:北京大学第一临床医学院_血液内科_期刊论文

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作者单位: 1.Hebei Yanda Hosp, Ludaopei Hematol & Oncol Ctr, Beijing, Peoples R China
2.Zunyi Med Coll, Affiliated Hosp, Dept Pediat, Zunyi, Peoples R China
3.Gen Hosp Armed Police, Dept Lab Med, Beijing, Peoples R China
4.Peking Univ, Hosp 1, Cent Lab, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Dept Hematol, Beijing 100034, Peoples R China

Recommended Citation:
Yang, Liyun,Chen, Xue,Liu, Hongxing,et al. Donors with HLA-B*58:01/TNF alpha-308A haplotype are unfavorable to haploidentical hematopoietic stem cell transplantation in acute lymphoblastic leukemia[J]. TRANSPLANT IMMUNOLOGY,2015,32(2):92-98.
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