IR@PKUHSC  > 北京大学深圳医院  > 皮肤性病科
学科主题临床医学
Identify the association between polymorphisms of BLK and systemic lupus erythematosus through unlabelled probe-based high-resolution melting analysis
Chen, Y.2; Wu, Q.1,3; Shao, Y.1,4; Zhang, J.1,4; Guan, M.5; Wan, J.3,6; Yu, B.1,3,4; Zhang, W.1,2,6
刊名INTERNATIONAL JOURNAL OF IMMUNOGENETICS
2012-08-01
DOI10.1111/j.1744-313X.2012.01094.x
39期:4页:321-327
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Immunology
研究领域[WOS]Genetics & Heredity ; Immunology
关键词[WOS]GENOME-WIDE ASSOCIATION ; HONG-KONG CHINESE ; SUSCEPTIBILITY ; POPULATION ; GENE ; REPLICATION ; VARIANTS ; REGION ; ITGAM ; BANK1
英文摘要

Systemic lupus erythematosus (SLE) is a complex immune disease. The genetic variation in the B lymphoid tyrosine kinase (BLK) gene was found to associate with SLE in Caucasian population. However, the association of rs13277113 and rs4840568 with SLE was not extensively studied in Chinese population. In this study, we aim to test the association of SNP rs13277113 and rs4840568 with the disease risk of SLE in Chinese mainland population. A total of 532 patients with SLE and 576 controls were recruited. Unlabelled probe-based high-resolution melting analysis (HRMA) was used in genotyping. HRMA with unlabelled probe successfully distinguished all genotypes. Significant differences were observed in both genotype and allele frequencies for rs13277113 and rs4840568. Minor alleles of rs13277113 (P = 4.2E-05, odds ratio [OR] 0.66, [95% CI 0.540.81]) and rs4840568 (P = 7.1E-05, OR 0.67, [95% CI 0.550.82]) were found to be protective against SLE. Polymorphisms of rs13277113 and rs4840568 in BLK gene were associated with SLE in Chinese population.

语种英语
WOS记录号WOS:000306078300008
资助机构Shenzhen-Hong Kong Technological Cooperation
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58559
专题北京大学深圳医院_皮肤性病科
北京大学口腔医学院_外科
作者单位1.Huashan Hosp, Dept Clin Lab, Shanghai, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 518036, Guangdong, Peoples R China
3.Ji Nan Univ, JNU HKUST Joint Lab, Guangzhou, Guangdong, Peoples R China
4.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
6.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Chen, Y.,Wu, Q.,Shao, Y.,et al. Identify the association between polymorphisms of BLK and systemic lupus erythematosus through unlabelled probe-based high-resolution melting analysis[J]. INTERNATIONAL JOURNAL OF IMMUNOGENETICS,2012,39(4):321-327.
APA Chen, Y..,Wu, Q..,Shao, Y..,Zhang, J..,Guan, M..,...&Zhang, W..(2012).Identify the association between polymorphisms of BLK and systemic lupus erythematosus through unlabelled probe-based high-resolution melting analysis.INTERNATIONAL JOURNAL OF IMMUNOGENETICS,39(4),321-327.
MLA Chen, Y.,et al."Identify the association between polymorphisms of BLK and systemic lupus erythematosus through unlabelled probe-based high-resolution melting analysis".INTERNATIONAL JOURNAL OF IMMUNOGENETICS 39.4(2012):321-327.
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