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学科主题: 临床医学
题名:
Identify the association between polymorphisms of BLK and systemic lupus erythematosus through unlabelled probe-based high-resolution melting analysis
作者: Chen, Y.2; Wu, Q.1,3; Shao, Y.1,4; Zhang, J.1,4; Guan, M.5; Wan, J.3,6; Yu, B.1,3,4; Zhang, W.1,2,6
刊名: INTERNATIONAL JOURNAL OF IMMUNOGENETICS
发表日期: 2012-08-01
DOI: 10.1111/j.1744-313X.2012.01094.x
卷: 39, 期:4, 页:321-327
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Immunology
研究领域[WOS]: Genetics & Heredity ; Immunology
关键词[WOS]: GENOME-WIDE ASSOCIATION ; HONG-KONG CHINESE ; SUSCEPTIBILITY ; POPULATION ; GENE ; REPLICATION ; VARIANTS ; REGION ; ITGAM ; BANK1
英文摘要:

Systemic lupus erythematosus (SLE) is a complex immune disease. The genetic variation in the B lymphoid tyrosine kinase (BLK) gene was found to associate with SLE in Caucasian population. However, the association of rs13277113 and rs4840568 with SLE was not extensively studied in Chinese population. In this study, we aim to test the association of SNP rs13277113 and rs4840568 with the disease risk of SLE in Chinese mainland population. A total of 532 patients with SLE and 576 controls were recruited. Unlabelled probe-based high-resolution melting analysis (HRMA) was used in genotyping. HRMA with unlabelled probe successfully distinguished all genotypes. Significant differences were observed in both genotype and allele frequencies for rs13277113 and rs4840568. Minor alleles of rs13277113 (P = 4.2E-05, odds ratio [OR] 0.66, [95% CI 0.540.81]) and rs4840568 (P = 7.1E-05, OR 0.67, [95% CI 0.550.82]) were found to be protective against SLE. Polymorphisms of rs13277113 and rs4840568 in BLK gene were associated with SLE in Chinese population.

语种: 英语
项目资助者: Shenzhen-Hong Kong Technological Cooperation
WOS记录号: WOS:000306078300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58559
Appears in Collections:北京大学深圳医院_皮肤性病科_期刊论文

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作者单位: 1.Huashan Hosp, Dept Clin Lab, Shanghai, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 518036, Guangdong, Peoples R China
3.Ji Nan Univ, JNU HKUST Joint Lab, Guangzhou, Guangdong, Peoples R China
4.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
6.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Chen, Y.,Wu, Q.,Shao, Y.,et al. Identify the association between polymorphisms of BLK and systemic lupus erythematosus through unlabelled probe-based high-resolution melting analysis[J]. INTERNATIONAL JOURNAL OF IMMUNOGENETICS,2012,39(4):321-327.
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