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学科主题: 精神卫生
题名:
A Two-Stage Association Study Suggests BRAP as a Susceptibility Gene for Schizophrenia
作者: Zhang, Fuquan1,2; Liu, Chenxing2; Xu, Yong3; Qi, Guoyang1; Yuan, Guozhen1; Cheng, Zaohuo1; Wang, Jidong1; Wang, Guoqiang1; Wang, Zhiqiang1; Zhu, Wei1; Zhou, Zhenhe1; Zhao, Xingfu1; Tian, Lin1; Jin, Chunhui1; Yuan, Janmin1; Zhang, Guofu1; Chen, Yaguang2; Wang, Lifang2; Lu, Tianlan2; Yan, Hao2; Ruan, Yanyan2; Yue, Weihua2; Zhang, Dai2,4,5
刊名: PLOS ONE
发表日期: 2014-01-15
DOI: 10.1371/journal.pone.0086037
卷: 9, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: PROTEIN INTERACTION NETWORKS ; GENOME-WIDE ASSOCIATION ; CORONARY-ARTERY-DISEASE ; ASIAN POPULATIONS ; HAN CHINESE ; RISK ; DISORDER ; SNPS ; POLYMORPHISMS ; VISUALIZATION
英文摘要:

Schizophrenia (SZ) is a neurodevelopmental disorder in which altered immune function typically plays an important role in mediating the effect of environmental insults and regulation of inflammation. The breast cancer suppressor protein associated protein (BRAP) is suggested to exert vital effects in neurodevelopment by modulating the mitogen-activated protein kinase cascade and inflammation signaling. To explore the possible role of BRAP in SZ, we conducted a two-stage study to examine the association of BRAP polymorphisms with SZ in the Han Chinese population. In stage one, we screened SNPs in BRAP from our GWAS data, which detected three associated SNPs, with rs3782886 being the most significant one (P = 2.31E-6, OR = 0.67). In stage two, we validated these three SNPs in an independently collected population including 1957 patients and 1509 controls, supporting the association of rs3782886 with SZ (P = 1.43E-6, OR = 0.73). Furthermore, cis-eQTL analysis indicates that rs3782886 genotypes are associated with mRNA levels of aldehyde dehydrogenase 2 family (ALDH2) (P = 0.0039) and myosin regulatory light chain 2 (MYL2) (P < 1.0E-4). Our data suggest that the BRAP gene may confer vulnerability for SZ in Han Chinese population, adding further evidence for the involvement of developmental and/or neuroinflammatory cascades in the illness.

语种: 英语
所属项目编号: 2009AA022702 ; 81000578 ; 81071087 ; 81071088 ; 81221002 ; 2011CB707805 ; 2010DFB30820
项目资助者: National High-Tech Research and Development Program of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; National Basic Research Program of China ; International Science &amp ; Technology Cooperation Program of China
WOS记录号: WOS:000330235100144
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58561
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi, Jiangsu, Peoples R China
3.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Inst Mental Hlth,Hosp 6, Beijing 100871, Peoples R China
4.Shanxi Med Univ, Dept Psychiat, Hosp 1, Taiyuan, Peoples R China
5.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Fuquan,Liu, Chenxing,Xu, Yong,et al. A Two-Stage Association Study Suggests BRAP as a Susceptibility Gene for Schizophrenia[J]. PLOS ONE,2014,9(1).
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