|Chronic obstructive pulmonary disease in the absence of chronic bronchitis in China|
|Lu, Ming2; Yao, Wanzhen2; Zhong, Nanshan1; Zhou, Yumin1; Wang, Chen3; Chen, Ping7; Kang, Jian8; Huang, Shaoguang9; Chen, Baoyuan10; Wang, Changzheng11; Ni, Diantao12; Wang, Xiaoping13; Wang, Dali4; Liu, Shengming1,5; Lu, Jiachun6; Shen, Ning2; Ran, Pixin1|
|关键词||chronic bronchitis chronic obstructive pulmonary disease clinical epidemiology cough|
|WOS标题词||Science & Technology|
|关键词[WOS]||AIR-FLOW OBSTRUCTION ; RESPIRATORY SYMPTOMS ; GENERAL-POPULATION ; UNITED-STATES ; LUNG-DISEASE ; COPD ; HEALTH ; ADULTS ; ASTHMA ; PREVALENCE|
Background and objective: COPD has a variable natural history and not all individuals follow the same course. The aim of this study was to assess the prevalence of COPD in the absence of chronic bronchitis (CB) based on a population survey in China, and to identify the determinants of CB in patients with COPD.
Methods: Amulti-stage cluster sampling strategy was used to survey a population from seven different provinces/cities of China. All residents over 40 years of age were interviewed using a standardized questionnaire and spirometry was measured. A post-bronchodilator FEV(1)/FVC < 70% was defined as the diagnostic criterion for COPD. All COPD patients who were screened were divided into two groups according to the presence or absence of CB.
Results: Of the population of 20 245 that was surveyed, 70% of the 1668 patients who were diagnosed with COPD reported no history of CB. The ages, BMI and comorbidities of COPD patients with or without CB were similar. Male gender, residence in a rural area, having a lower level of education, exposure to tobacco smoke or biomass fuels, poor ventilation in the kitchen and a family history of respiratory disease were all associated with a higher risk of COPD with CB. Patients without CB had less difficulty in walking and higher FEV(1)/FVC values than patients with CB, but were more likely to be underdiagnosed. The strongest predictors of CB were male gender, current smoking and severity of dyspnoea.
Conclusions: This survey confirmed that there is a high prevalence of COPD in the absence of CB in China. It appears that CB is not essential to the diagnosis of COPD.
|项目编号||2001BA703B03(A) ; B30301|
|资助机构||Chinese Central Government ; Guangdong Key Research Project|
|作者单位||1.Guangzhou Med Univ, State Key Lab Resp Dis, Guangzhou Inst Resp Dis, Affiliated Hosp 1, Guangzhou 510182, Guangdong, Peoples R China|
2.Peking Univ, Hosp 3, Dept Resp Med, Beijing 100871, Peoples R China
3.Capital Univ Med Sci, Beijing Inst Resp Med, Beijing Chaoyang Hosp, Beijing, Peoples R China
4.Second Hosp Liwan Dist Guangzhou, Dept Resp Med, Guangzhou, Guangdong, Peoples R China
5.Jinan Univ, Dept Resp Med, Affiliated Hosp 1, Jinan, Peoples R China
6.Guangzhou Med Univ, Dept Epidemiol, Guangzhou 510182, Guangdong, Peoples R China
7.Shenyang Mil Gen Hosp, Dept Resp Med, Shenyang, Peoples R China
8.China Med Univ, Dept Resp Med, Affiliated Hosp 1, Shenyang, Peoples R China
9.Shanghai Jiao Tong Univ, Dept Resp Med, Ruijin Hosp, Sch Med, Shanghai 200030, Peoples R China
10.Tianjin Med Univ, Gen Hosp, Dept Resp Med, Tianjin, Peoples R China
11.Third Mil Med Univ, Dept Resp Med, Xinqiao Hosp, Chongqing, Peoples R China
12.Fourth Mil Med Univ, Dept Resp Med, Xijing Hosp, Xian 710032, Peoples R China
13.First Municipal People Hosp Shaoguan, Dept Resp Med, Shaoguan, Peoples R China
|Lu, Ming,Yao, Wanzhen,Zhong, Nanshan,et al. Chronic obstructive pulmonary disease in the absence of chronic bronchitis in China[J]. RESPIROLOGY,2010,15(7):1072-1078.|
|APA||Lu, Ming.,Yao, Wanzhen.,Zhong, Nanshan.,Zhou, Yumin.,Wang, Chen.,...&Ran, Pixin.(2010).Chronic obstructive pulmonary disease in the absence of chronic bronchitis in China.RESPIROLOGY,15(7),1072-1078.|
|MLA||Lu, Ming,et al."Chronic obstructive pulmonary disease in the absence of chronic bronchitis in China".RESPIROLOGY 15.7(2010):1072-1078.|