IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Study of binding glycyrrhetic acid to AT(1) receptor
Zhang, FY; Yue, BZ; He, SP
关键词glycyrrhetic acid (GA) AT(1) receptor intracellular [Ca2+,](i) c-myc cell proliferation
刊名SCIENCE IN CHINA SERIES C-LIFE SCIENCES
2003-04-01
46期:2页:194-204
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
英文摘要

To analyze the binding of glycyrrhetic acid (GA) to angiotensin II type I (AT(1)) receptor and to explore the mechanisms underlying the binding, primary cell culture of rat vascular smooth muscle cell (VSMC), radioactive ligand-receptor binding assay, lascer confocal scanning microscope (LCSM), Northern blot, H-3-TdR incorporation DNA assay were used in this study. The results suggest that specific binding of GA to AT(1) receptor (IC50 value was 35.0 mumol/L) increases intracellular [Ca2+](i) of VSMC, activates transcription factor c-myc and promotes the proliferation of VSMC, therefore GA was probably an agonist of AT(1) receptor, providing a new target for GA:s pharmaceutical effects.

语种英语
WOS记录号WOS:000181791600009
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58568
专题北京大学基础医学院_生物物理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, FY,Yue, BZ,He, SP. Study of binding glycyrrhetic acid to AT(1) receptor[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2003,46(2):194-204.
APA Zhang, FY,Yue, BZ,&He, SP.(2003).Study of binding glycyrrhetic acid to AT(1) receptor.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,46(2),194-204.
MLA Zhang, FY,et al."Study of binding glycyrrhetic acid to AT(1) receptor".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 46.2(2003):194-204.
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