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学科主题: 临床医学
题名:
Determination of telmisartan in human plasma by liquid chromatography-tandem mass spectrometry
作者: Li, PF; Wang, YW; Wang, Y; Tang, YB; Fawcett, JP; Cui, YM; Gu, JK
关键词: telmisartan ; LC-MS/MS
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2005-12-15
DOI: 10.1016/j.jchromb.2005.09.021
卷: 828, 期:1-2, 页:126-129
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
英文摘要:

A rapid, selective and sensitive method for the determination of the angiotensin 11 receptor antagonist, telmisartan, in human plasma has been developed. Telmisartan and the internal standard, diphenhydramine, were extracted from plasma using diethyl ether-dichloromethane (60:40, v/v), and separated on a Zorbax extend C-18 column using methanol-10 mM ammonium acetate (85:15, v/v) adjusted to pH 4.5 after mixing with formic acid as mobile phase. Detection was carried out by multiple reaction monitoring on a Q-trap (TM) LC-MS/MS system with an ESI interface. The assay was linear over the range 0.5-600.0 ng/ml with a limit of quantitation of 0.5 ng/ml and a limit of detection of 0.05 ng/ml. Intra- and inter-day precision were < 6.7% and < 8.1%, respectively, and the accuracy was in the range 88.9-111.0%. The assay was applied to a pharmacokinetic study of telmisartan given as a single oral dose (80 mg) to healthy volunteers. (c) 2005 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000233944100020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58569
Appears in Collections:北京大学第一临床医学院_药剂科_期刊论文

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作者单位: 1.Jilin Univ, Coll Life Sci, Res Ctr Drug Metab, Changchun 130023, Peoples R China
2.Univ Otago, Sch Pharm, Dunedin, New Zealand
3.Peking Univ, Hosp 1, Dept Pharm, Beijing 100034, Peoples R China

Recommended Citation:
Li, PF,Wang, YW,Wang, Y,et al. Determination of telmisartan in human plasma by liquid chromatography-tandem mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2005,828(1-2):126-129.
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