IR@PKUHSC  > 北京大学第一临床医学院  > 药剂科
学科主题临床医学
Determination of telmisartan in human plasma by liquid chromatography-tandem mass spectrometry
Li, PF; Wang, YW; Wang, Y; Tang, YB; Fawcett, JP; Cui, YM; Gu, JK
关键词telmisartan LC-MS/MS
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2005-12-15
DOI10.1016/j.jchromb.2005.09.021
828期:1-2页:126-129
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
英文摘要

A rapid, selective and sensitive method for the determination of the angiotensin 11 receptor antagonist, telmisartan, in human plasma has been developed. Telmisartan and the internal standard, diphenhydramine, were extracted from plasma using diethyl ether-dichloromethane (60:40, v/v), and separated on a Zorbax extend C-18 column using methanol-10 mM ammonium acetate (85:15, v/v) adjusted to pH 4.5 after mixing with formic acid as mobile phase. Detection was carried out by multiple reaction monitoring on a Q-trap (TM) LC-MS/MS system with an ESI interface. The assay was linear over the range 0.5-600.0 ng/ml with a limit of quantitation of 0.5 ng/ml and a limit of detection of 0.05 ng/ml. Intra- and inter-day precision were < 6.7% and < 8.1%, respectively, and the accuracy was in the range 88.9-111.0%. The assay was applied to a pharmacokinetic study of telmisartan given as a single oral dose (80 mg) to healthy volunteers. (c) 2005 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000233944100020
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58569
Collection北京大学第一临床医学院_药剂科
作者单位1.Jilin Univ, Coll Life Sci, Res Ctr Drug Metab, Changchun 130023, Peoples R China
2.Univ Otago, Sch Pharm, Dunedin, New Zealand
3.Peking Univ, Hosp 1, Dept Pharm, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Li, PF,Wang, YW,Wang, Y,et al. Determination of telmisartan in human plasma by liquid chromatography-tandem mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2005,828(1-2):126-129.
APA Li, PF.,Wang, YW.,Wang, Y.,Tang, YB.,Fawcett, JP.,...&Gu, JK.(2005).Determination of telmisartan in human plasma by liquid chromatography-tandem mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,828(1-2),126-129.
MLA Li, PF,et al."Determination of telmisartan in human plasma by liquid chromatography-tandem mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 828.1-2(2005):126-129.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Li, PF]'s Articles
[Wang, YW]'s Articles
[Wang, Y]'s Articles
百度学术
百度学术Similar articles in
[Li, PF]'s Articles
[Wang, YW]'s Articles
[Wang, Y]'s Articles
必应学术
必应学术Similar articles in
[Li, PF]'s Articles
[Wang, YW]'s Articles
[Wang, Y]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.